Abstract：
:A calcium-dependent potassium channel K(Ca) has been isolated in mouse motoneurons. With physiological concentrations of potassium across inside-out patches, a 100 pS K(Ca) channel was activated when the bath solution of Ca2+ was in excess of 1 microM. Introduction of the drug tedisamil, a blocker of repolarizing potassium channels in cardiac cells, at concentrations in the range 0.2-10 microM, caused a dose-dependent decrease in the mean open times for K(Ca). The drug action was consistent with open channel block of K(Ca) with an onward (blocking) rate constant of 6 x 10(7) M-1 s-1. Tedisamil, at concentrations of 1 microM and 5 microM, also blocked the K(Ca) channel when applied to outside-out patches with a similar potency as found with internal application. A large conductance K(Ca) channel in hippocampal neurons is also blocked by a number of putative Class III antiarrhythmic drugs, including tedisamil; thus, these agents may have utility in the characterization of the properties of K(Ca) channels in various cells.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
McLarnon JG,Sawyer D,Michikawa M,Kim SUdoi
10.1016/0304-3940(92)90746-tkeywords:
subject
Has Abstractpub_date
1992-09-14 00:00:00pages
185-8issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(92)90746-Tjournal_volume
144pub_type
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01330-6
更新日期：2000-08-25 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90039-6
更新日期：1989-10-23 00:00:00
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journal_title：Neuroscience letters
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更新日期：2011-05-27 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1987-07-22 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2003-12-15 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1986-05-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1988-05-03 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-01-24 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1995-06-09 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1992-02-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90923-9
更新日期：1993-09-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.06.061
更新日期：2004-09-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.10.041
更新日期：2007-01-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2011.11.022
更新日期：2012-01-11 00:00:00
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journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2014.03.060
更新日期：2014-06-06 00:00:00
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journal_title：Neuroscience letters
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更新日期：2002-10-11 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：2010-12-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2003-11-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1990-02-05 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.12.025
更新日期：2019-03-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.06.039
更新日期：2016-08-26 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90321-2
更新日期：1989-09-25 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2011.10.004
更新日期：2011-11-14 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.02.038
更新日期：2015-06-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(79)95335-7
更新日期：1979-09-01 00:00:00
