Abstract:
:The potential neurotoxicity of the solvent toluene to the nigrostriatal dopaminergic system was assessed in a rat model of Parkinson's disease. Rats, 1 day after a unilateral injection of 6-hydroxydopamine (6-OH DA) into the substantia nigra, inhaled air or different concentrations of toluene (80, 300 or 1000 ppm), 6 h/day for 3 days. The animals were sacrificed 2 days after the last exposure and biochemical measurements of catecholamines and 3,4-dihydroxyphenylacetic acid (DOPAC) were performed in the neostriatum and substantia nigra. Toluene at 80 and 1000 ppm significantly enhanced the depletion of striatal DOPAC levels induced by the lesion and produced at 80 and 300 ppm a trend for intensifying the 6-OH DA-induced depletion of striatal DA stores. The alterations induced after the combined challenge to the dopaminergic nigrostriatal system may reflect endangering actions of toluene.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cintra A,Andbjer B,Finnman UB,Hagman M,Agnati LF,Höglund G,Fuxe Kdoi
10.1016/0304-3940(96)13049-4subject
Has Abstractpub_date
1996-10-11 00:00:00pages
61-5issue
1eissn
0304-3940issn
1872-7972pii
S0304394096130494journal_volume
217pub_type
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