Abstract:
:Nociceptin/orphanin FQ (N/OFQ) is an endogenous peptide agonist for the opioid receptor homolog, N/OFQ receptor, and serves for the central control of autonomic functions. Morphological details including the cell types that may account for such N/OFQ functions, however, remain unclear. By using X-gal histochemistry for the detection of receptor-expressing cells at both light and electron microscopic levels, we examined the hypothalamus from the receptor-deficient mice bearing a lacZ insertional mutation in the N/OFQ receptor gene. The N/OFQ receptor reflected by lacZ expression was seen at high levels in the anterior hypothalamic area. With electron microscopy, lacZ expression was observed in a subset of neurons showing large cell size and indented nucleus.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Houtani T,Ikeda M,Kase M,Sato K,Sakuma S,Kakimoto S,Ueyama T,Munemoto Y,Takeshima H,Sugimoto Tdoi
10.1016/s0304-3940(02)01186-2keywords:
subject
Has Abstractpub_date
2003-01-02 00:00:00pages
217-9issue
3eissn
0304-3940issn
1872-7972pii
S0304394002011862journal_volume
335pub_type
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