Decreased susceptibility to pentylenetetrazol-induced seizures after low-frequency transcranial magnetic stimulation in rats.

Abstract:

:We studied the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on seizure susceptibility in rats. rTMS of 1000 pulses at 0.5 Hz led to a prolonged latency for seizure development after an intraperitoneal injection of pentylenetetrazol. The rTMS effectively prevented the development of status epilepticus of pentylenetetrazol-induced convulsions. These findings indicate that low-frequency rTMS affects the neural excitability, in the direction of anticonvulsive, and therefore, suggest the possibility of therapeutic use of rTMS in epilepsy.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Akamatsu N,Fueta Y,Endo Y,Matsunaga K,Uozumi T,Tsuji S

doi

10.1016/s0304-3940(01)02116-4

keywords:

subject

Has Abstract

pub_date

2001-09-14 00:00:00

pages

153-6

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

S0304394001021164

journal_volume

310

pub_type

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