Activation of NRF2/ARE by isosilybin alleviates Aβ25-35-induced oxidative stress injury in HT-22 cells.

abstract：:We recently reported here that SNCA triplication results in a doubling in the amount of alpha-synuclein protein in blood from cases with hereditary Lewy body disease. This observation shows that alpha-synuclein levels in blood accurately reflect gene dosage, which we assume drives pathogenesis in these individuals. A ...

journal_title：Neuroscience letters

authors： Miller DW,Crawley A,Gwinn-Hardy K,Lopez G,Nussbaum R,Cookson MR,Singleton AB,Hardy J,Dogu O

更新日期：2005-02-21 00:00:00

abstract：:Double retrograde axonal tracers (horseradish peroxidase, (HRP) and [3H]apo-HRP) have been used to study the distribution of labeled cells in the cat claustrum. Paired injections were made into different fields of the visual cortical areas. Although the areas of distribution of single-labeled claustral neurons from di...

journal_title：Neuroscience letters

authors： Norita M

更新日期：1983-03-28 00:00:00

abstract：:The neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal total biopterin were examined both in rats and mice at different time courses. Results indicate that MPTP caused a significant decrease of total biopterin content in the striatum of mice. This effect occurred as soon as 6 h after...

journal_title：Neuroscience letters

authors： Lee EH

更新日期：1988-06-07 00:00:00

abstract：:During neuromuscular development, the nerve induces the expression of acetylcholine receptor (AChR) epsilon-subunit gene selectively in synaptic myonuclei. Here we show that even after elimination of neural effects by denervation, synaptic expression of epsilon-subunit transcripts is maintained for > 4 months. In cont...

journal_title：Neuroscience letters

authors： Herczeg A,Jones G,Brenner HR

更新日期：1995-06-23 00:00:00

abstract：:The opioid peptide dynorphin A(1-8) (1 micron) increased acetylcholine release from the Torpedo electric organ by approximately twofold. This effect was reversed by the opiate antagonist naloxone. The effect of Dyn A(1-8) on acetylcholine release was found to vary in magnitude with the seasons of the year, with maxima...

journal_title：Neuroscience letters

authors： Oron L,Sarne Y,Michaelson DM

更新日期：1991-04-29 00:00:00

abstract：:The cellular localisation of benzodiazepine receptors was studied. Kainic acid induced neuronal lesions (2 x 0.25-2 x 2 micrograms; 2-26 days in rat cerebellum decreased specific binding of [3H]flunitrazepam down to 35% of controls. Specific binding of [3H]flunitrazepam was also decreased (to 80% of controls) in the c...

journal_title：Neuroscience letters

authors： Braestrup C,Nielsen M,Biggio G,Squires RF

更新日期：1979-08-01 00:00:00

abstract：:We investigated the secretion of amyloid beta-protein (beta AP) in a mouse neuronal cell line SN49. SN49 cells stably transfected with mouse beta-amyloid precursor protein (APP) 695 cDNA released approximately three times greater amounts of a 4 kDa protein immunoreactive with anti-beta AP antibodies than untransfected...

journal_title：Neuroscience letters

authors： Araki W,Kunishita T,Takahashi K,Ikeda S,Tabira T

更新日期：1994-02-14 00:00:00

abstract：:The primary component of amyloid deposits found in the brains of patients with Alzheimer's disease is the beta-amyloid protein, a derivative of a much larger precursor protein (beta PP). We have previously reported that overexpression of carboxyl (COOH)-terminal fragments of beta PP from an integrated DNA construct le...

journal_title：Neuroscience letters

authors： Fukuchi K,Sopher B,Furlong CE,Smith AC,Dang N,Martin GM

更新日期：1993-05-14 00:00:00

abstract：:Increasing evidence suggests a relation between vascular disorders and late-onset Alzheimer's disease (AD). We performed an association analysis of low-density lipoprotein receptor-related protein (LRP), lipoprotein lipase (LPL), and angiotensin converting enzyme (ACE) genes, known to be involved in vascular disorders...

journal_title：Neuroscience letters

authors： Myllykangas L,Polvikoski T,Sulkava R,Verkkoniemi A,Tienari P,Niinistö L,Kontula K,Hardy J,Haltia M,Pérez-Tur J

更新日期：2000-10-13 00:00:00

abstract：:Impaired energy metabolism plays an important role in neuronal cell death after brain ischemia, and apoptosis has been implicated in cell death induced by metabolic impairment. In the present study, metabolic impairment was induced by 3-nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase. ...

journal_title：Neuroscience letters

authors： Sugino T,Nozaki K,Tokime T,Hashimoto N,Kikuchi H

更新日期：1997-11-21 00:00:00

abstract：:Day-night variations of gastrin releasing peptide (GRP) in the neuronal somal area of the SCN and the nearby region on the anterior hypothalamic area (AHA) where GRP fibers project, were examined by semiquantitative immunocytochemistry, and compared with those of vasoactive intestinal peptide (VIP). Both in the SCN an...

journal_title：Neuroscience letters

authors： Okamura H,Ibata Y

更新日期：1994-11-07 00:00:00

abstract：:We examined the effects of ibotenic acid induced unilateral lesion of the nucleus basalis magnocellularis (nBM) on carbachol- and serotonin-stimulated phosphoinositide (PI) breakdown in miniprisms obtained from rat fronto-parietal cortex 1 week following the lesion. Lesion-side muscarinic and serotoninergic receptor r...

journal_title：Neuroscience letters

authors： Erfurth A,Holmes TC

更新日期：1995-06-23 00:00:00

abstract：:Dominance hierarchies within social groups determine resource distribution. Resources, such as food and access to mating partners, can act as reinforcers. The present study examined the effect of social rank on access to wheel running-a reinforcing behavior performed by laboratory animals. Mice were identified as domi...

journal_title：Neuroscience letters

authors： Vargas-Pérez H,Sellings L,Grieder T,Díaz JL

更新日期：2009-07-03 00:00:00

abstract：:Corticokinematic coherence (CKC), i.e., coherence calculated between MEG and an accelerometer signal, recording movement kinematics, can be used for functional mapping of the sensorimotor cortex. Cortical sources of CKC, induced by both voluntary and passive movements, localize at the proximity of sensorimotor cortex....

journal_title：Neuroscience letters

authors： Airaksinen K,Lehti T,Nurminen J,Luoma J,Helle L,Taulu S,Pekkonen E,Mäkelä JP

更新日期：2015-08-18 00:00:00

abstract：:We have previously demonstrated that repeated exposure of adult rat hippocampal slices to brief episodes of hypoxia induce a sustained decrease in the threshold of stimulus-evoked population spike discharges in CA1 pyramidal neurons [O. Godukhin, A. Savin, S. Kalemenev, S. Levin, Neuronal hyperexcitability induced by ...

journal_title：Neuroscience letters

authors： Levin S,Godukhin O

更新日期：2005-03-22 00:00:00

abstract：:Chronic treatment with antidepressant drugs (2 weeks or longer) increases corticosteroid receptor mRNA expression in the hippocampus and reduces hypothalamic-pituitary-adrenal axis activity in parallel with improving mood and neuroendocrine function. Earlier effects are less well documented. We examined the effects of...

journal_title：Neuroscience letters

authors： Yau JL,Noble J,Hibberd C,Seckl JR

更新日期：2001-06-29 00:00:00

abstract：:Gastrin releasing peptide (GRP) is involved in the stimulation of gastric acid release from the stomach. It also mediates effects on feeding behavior. It is associated with anorexigenic effects in both mammalian and avian species, but the mechanism of action is unknown in any species. The aim of the present study was ...

journal_title：Neuroscience letters

authors： Bohler M,Dougherty C,Tachibana T,Gilbert ER,Cline MA

更新日期：2019-11-20 00:00:00

abstract：:The present investigation examined the effect of inflammation produced by intravesical zymosan on spinal dorsal horn neuronal responses to urinary bladder distension (UBD). Extracellular single-unit recordings of neurons excited by UBD were obtained in spinalized female Sprague-Dawley rats. Neurons were classified as ...

journal_title：Neuroscience letters

authors： Ness TJ,Castroman PJ,Randich A

更新日期：2009-12-25 00:00:00

abstract：:The light microscopic localization of gamma-aminobutyric acidB (GABAB) receptors in the rat brain has been accomplished using in vitro autoradiography with [3H]baclofen as a ligand. Initial biochemical studies indicated this compound specifically bound to slide-mounted tissue sections with high affinity in a saturable...

journal_title：Neuroscience letters

authors： Gehlert DR,Yamamura HI,Wamsley JK

更新日期：1985-05-14 00:00:00

abstract：:In lateral line and electrosensory systems of fish, the animal's own movements create unwanted stimulation that could interfere with the detection of biologically important signals. Here we report that an adaptive filter in the medullary nuclei of both senses suppresses self-stimulation. Second-order electrosensory ne...

journal_title：Neuroscience letters

authors： Montgomery JC,Bodznick D

更新日期：1994-06-20 00:00:00

abstract：:Pineal serotonin (5-HT), 5-hydroxyindole-acetic acid (5-HIAA), norepinephrine (NE), epinephrine (E) and adrenal corticosterone, NE and E contents were measured spectrofluorometrically 5, 15, 30 and 60 min after insulin treatment to induce hypoglycemic stress. In the pineal gland, hypoglycemic stress caused dramatic de...

journal_title：Neuroscience letters

authors： Mahata SK

更新日期：1991-01-02 00:00:00

abstract：:We have studied nicotinic acetylcholine receptors in spontaneously hypertensive 'stroke prone' (SHsp) rats. We found a significant decrease in 125I-alpha-bungarotoxin binding and alpha7 subunit mRNA levels in cortical areas of the SHsp rats with respect to Wistar Kyoto (WKy) normotensive rats. Antihypertensive drug tr...

journal_title：Neuroscience letters

authors： Ferrari R,Frasoldati A,Leo G,Torri C,Zini I,Agnati LF,Zoli M

更新日期：1999-12-31 00:00:00

abstract：:The present study was designed to determine whether a state of neuropathic pain induced by sciatic nerve ligation could alter phosphorylated-mu-opioid receptor-like immunoreactivity in the superficial dorsal horn of the mouse spinal cord. Mice with sciatic nerve ligation exhibited a significant suppression of the morp...

journal_title：Neuroscience letters

authors： Narita M,Kuzumaki N,Suzuki M,Narita M,Oe K,Yamazaki M,Yajima Y,Suzuki T

更新日期：2004-01-09 00:00:00

abstract：:Optic fibre regeneration in young Xenopus was studied by [(3)H]proline autoradiography and by mapping the visuotectal projection electrophysiologically from 5 to 210 days after sectioning the right optic nerve. Regenerated optic fibers were demonstrated morphologically both in the contra and ipsilateral tecta. In cont...

journal_title：Neuroscience letters

authors： Glastonbury J,Straznicky K

更新日期：1978-01-01 00:00:00

abstract：:Penicillins are thought to be GABA receptor antagonists. In order to determine the affinities of various penicillin derivatives for the GABA receptor, their potencies as inhibitors of specific [3H]GABA binding to rat brain membranes were investigated. All investigated penicillins inhibit specific [3H]GABA binding, wit...

journal_title：Neuroscience letters

authors： Antoniadis A,Müller WE,Wollert U

更新日期：1980-07-01 00:00:00

abstract：:Early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH) is one of the most common forms of autosomal recessive cerebellar ataxia. We identified six new alternative transcripts produced by the aprataxin gene responsible for EAOH. Total eight transcripts encoded truncated proteins that were located withi...

journal_title：Neuroscience letters

authors： Hirano M,Nishiwaki T,Kariya S,Furiya Y,Kawahara M,Ueno S

更新日期：2004-08-12 00:00:00

abstract：:Peripheral neuropathies are a group of acquired and hereditary disorders presenting with different distribution and nerve fiber class involvement. The overall prevalence is 2.4%, increasing to 8% in the elderly population. However, the frequency may vary depending on the underlying pathogenesis and association with sy...

journal_title：Neuroscience letters

authors： Merkies IS,Faber CG,Lauria G

更新日期：2015-06-02 00:00:00

abstract：:The pattern of projection of the ventrobasal thalamic complex (VB) upon the neocortical barrel field of normal and reeler mutant mice was determined by orthograde degeneration experiments and by Timm's histochemical method. In both reeler and normal mice the thalamic terminals are concentrated at the midcortical zone ...

journal_title：Neuroscience letters

authors： Caviness VS Jr,Frost DO,Hayes NL

更新日期：1976-09-01 00:00:00

abstract：:Cyclophosphamide (CP) has been used as an antitumour agent or immunosuppressant clinically, though the potential biological role of CP in the central nervous system (CNS) has not been clarified. In the present study, we found that pretreatment with CP prevented neuronal cell death caused by serum deprivation in cultur...

journal_title：Neuroscience letters

authors： Kitazawa H,Numakawa T,Adachi N,Kumamaru E,Tuerxun T,Kudo M,Kunugi H

更新日期：2010-02-12 00:00:00

abstract：:On anesthetized adult rats, we examined the possibility that the discharges of spinocerebellar Purkinje cells (PCs) are modulated by passive limb positioning. The rat forelimb was passively placed in four different sagittal positions while the simple spike spontaneous activity of single PCs was recorded; recordings st...

journal_title：Neuroscience letters

authors： Giaquinta G,Casabona A,Valle MS,Bosco G,Perciavalle V

更新日期：1998-04-03 00:00:00