Abstract:
:Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Dragunow M,Beilharz E,Mason B,Lawlor P,Abraham W,Gluckman Pdoi
10.1016/0304-3940(93)90420-psubject
Has Abstractpub_date
1993-10-01 00:00:00pages
232-6issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90420-Pjournal_volume
160pub_type
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