Brain-derived neurotrophic factor expression after long-term potentiation.

Abstract:

:Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Dragunow M,Beilharz E,Mason B,Lawlor P,Abraham W,Gluckman P

doi

10.1016/0304-3940(93)90420-p

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

232-6

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(93)90420-P

journal_volume

160

pub_type

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