Role of alpha 1 and alpha 2-adrenoceptors of the lateral hypothalamic area on urinary excretion caused by centrally administered angiotensin II.

Abstract:

:To determine whether central alpha 1 and alpha 2-adrenergic mechanisms are involved in urinary sodium and potassium excretion and urine volume induced by angiotensin II (ANGII), these renal parameters were measured in volume-expanded Holtzman rats with cannulas implanted into lateral ventricle (LV) and lateral hypothalamus (LH). The injection of ANGII into LV in rats with volume expansion reduced the sodium, potassium and urine excretion in comparison to the control injections of isotonic saline, whereas prazosin (alpha 1 antagonist) potentiated these effects. Clonidine (alpha 2 agonist) and yohimbine (alpha 2 antagonist) injected into LH previous to injection of ANGII into LV also abolished the inhibitory effect of ANGII. These results suggest that the discharge of central alpha-adrenergic receptors has dual inhibitory and excitatory effect on antinatriuretic, antikaliuretic and antidiuretic effect induced by central ANGII in volume-expanded rats.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Saad WA,Camargo LA,Renzi A,Menani JV,Saad WA

doi

10.1016/0304-3940(95)11751-h

subject

Has Abstract

pub_date

1995-07-21 00:00:00

pages

169-72

issue

3

eissn

0304-3940

issn

1872-7972

pii

030439409511751H

journal_volume

194

pub_type

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