Abstract:
:To determine whether central alpha 1 and alpha 2-adrenergic mechanisms are involved in urinary sodium and potassium excretion and urine volume induced by angiotensin II (ANGII), these renal parameters were measured in volume-expanded Holtzman rats with cannulas implanted into lateral ventricle (LV) and lateral hypothalamus (LH). The injection of ANGII into LV in rats with volume expansion reduced the sodium, potassium and urine excretion in comparison to the control injections of isotonic saline, whereas prazosin (alpha 1 antagonist) potentiated these effects. Clonidine (alpha 2 agonist) and yohimbine (alpha 2 antagonist) injected into LH previous to injection of ANGII into LV also abolished the inhibitory effect of ANGII. These results suggest that the discharge of central alpha-adrenergic receptors has dual inhibitory and excitatory effect on antinatriuretic, antikaliuretic and antidiuretic effect induced by central ANGII in volume-expanded rats.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Saad WA,Camargo LA,Renzi A,Menani JV,Saad WAdoi
10.1016/0304-3940(95)11751-hsubject
Has Abstractpub_date
1995-07-21 00:00:00pages
169-72issue
3eissn
0304-3940issn
1872-7972pii
030439409511751Hjournal_volume
194pub_type
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