Ultrastructural characteristics of circadian pacemaker neurones, immunoreactive to an antibody against a pigment-dispersing hormone in the fly's brain.

Abstract:

:Neurones immunoreactive to an antibody against a pigment-dispersing hormone (PDH-ir) are considered to be pacemaker cells in the neuronal circadian system of flies. We investigated the ultrastructure of PDH-ir varicosities, possible releasing sites of the PDH-like peptide, in the distal medulla of the optic lobe and in the dorsal protocerebrum of the two fly species Drosophila melanogaster and Musca domestica. In both species PDH-ir varicosities show accumulation of dense core vesicles (DCVs). PDH-like peptide is localized in the DCVs as shown by post-embedding immuno-electron microscopy. Localization of PDH-like peptide in DCVs and normally lacking synaptic specializations at PDH-ir varicosities in the medulla are interpreted as a non-synaptic paracrine release of peptide.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Miskiewicz K,Pyza E,Schürmann FW

doi

10.1016/j.neulet.2004.03.051

keywords:

subject

Has Abstract

pub_date

2004-06-03 00:00:00

pages

73-7

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304394004003647

journal_volume

363

pub_type

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