Nitric oxide inhibits depolarization-induced release of endogenous dopamine in the rabbit retina.

abstract：:Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are chemogenetic tools commonly-used to manipulate brain activity. The most widely-used synthetic DREADD ligand, clozapine-N-oxide (CNO), is back-metabolized to clozapine which can itself activate endogenous receptors. Studies in non-DREADD-expressin...

journal_title：Neuroscience letters

authors： Tran FH,Spears SL,Ahn KJ,Eisch AJ,Yun S

更新日期：2020-11-20 00:00:00

abstract：:The dopamine system in the limbic-prefrontal cortex has been assumed to play an important role in the cognitive dysfunction of schizophrenia and phencyclidine (PCP)-induced psychosis. In the present study, the role of metabotropic glutamate (mGlu) receptor subtypes on PCP-induced cortical dopamine release was investig...

journal_title：Neuroscience letters

authors： Maeda J,Suhara T,Okauchi T,Semba J

更新日期：2003-01-23 00:00:00

abstract：:Nicotine is known to stimulate energy expenditure, although the precise mechanism is unclear. To clarify the involvement of corticotropin-releasing factor (CRF) in the mechanism by which nicotine increases energy expenditure, the effect of intraperitoneal injection of nicotine (0.1 or 0.5mg/kg) on the release of norad...

journal_title：Neuroscience letters

authors： Mano-Otagiri A,Iwasaki-Sekino A,Ohata H,Arai K,Shibasaki T

更新日期：2009-05-08 00:00:00

abstract：:Mesial temporal lobe epilepsy (MTLE) is a common type of intractable epilepsy characterized by astroglial gliosis. The S100B was viewed as an astrocyte marker and experimental studies indicated that S100B might be involved in the pathophysiology of temporal lobe epilepsy. In this study, we measured plasma S100B levels...

journal_title：Neuroscience letters

authors： Lu C,Li J,Sun W,Feng L,Li L,Liu A,Li J,Mao W,Wei H,Gao L,Zhang X,Huang Z,Meng X,Wang Y

更新日期：2010-10-29 00:00:00

abstract：:We show that people continuously react to time perturbations in the range 3-96 ms in otherwise isochronous sound sequences. Musically trained and untrained participants were asked to synchronize with a sequence of sounds, and these two groups performed almost equally below the threshold for conscious detection of the ...

journal_title：Neuroscience letters

authors： Madison G,Merker B

更新日期：2004-11-03 00:00:00

abstract：:The MgATP-dependent priming step of exocytosis has been suggested to be regulated negatively by GTP-binding protein G0 in permeabilized adrenal chromaffin cells. We have reported that synaptosomal-associated protein of 25 kDa (SNAP-25) and vesicle-associated membrane protein 2 (VAMP-2) form a complex in chromaffin cel...

journal_title：Neuroscience letters

authors： Misonou H,Ohara-Imaizumi M,Kumakura K

更新日期：1997-09-05 00:00:00

abstract：:The association of alpha-synuclein (alpha-syn) neuropathology with Parkinson's disease (PD) and several related disorders has led to an intense research effort to develop cerebrospinal fluid (CSF)- or blood-based alpha-syn biomarkers for these types of diseases. Recent studies show that alpha-syn is present in CSF and...

journal_title：Neuroscience letters

authors： Ohrfelt A,Grognet P,Andreasen N,Wallin A,Vanmechelen E,Blennow K,Zetterberg H

更新日期：2009-02-06 00:00:00

abstract：:The effect of short-term exercise (15 min step-exercise) on serum brain-derived neurotrophic factor (BDNF) levels was evaluated in healthy human subjects. Results showed a short-term, significant increase in serum BDNF levels after exercise. Intra-individual differences in serum BDNF levels were remarkably small on th...

journal_title：Neuroscience letters

authors： Tang SW,Chu E,Hui T,Helmeste D,Law C

更新日期：2008-01-24 00:00:00

abstract：:Reciprocal Ia inhibition from ankle flexors to extensors was studied in five patients with spasticity due to incomplete traumatic spinal cord lesions. Nine healthy subjects were tested as controls. Excitability of the soleus motoneuron pool was estimated by H-reflex testing in the resting state. Ia inhibition was acti...

journal_title：Neuroscience letters

authors： Boorman G,Hulliger M,Lee RG,Tako K,Tanaka R

更新日期：1991-06-10 00:00:00

abstract：:The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indole...

journal_title：Neuroscience letters

authors： Prevedello MR,Ritta MN,Cardinali DP

更新日期：1979-06-01 00:00:00

abstract：:The insular cortex (IC) processes multimodal sensory information including gustatory, visceral, nociceptive, and thermal sensation, and is considered to play a role in the regulation of homeostasis. The IC receives dense histaminergic projection from the tuberomamillary nucleus in the hypothalamus, and recent studies ...

journal_title：Neuroscience letters

authors： Takei H,Song L,Ebihara K,Shirakawa T,Koshikawa N,Kobayashi M

更新日期：2012-06-14 00:00:00

abstract：:AMPA receptor (AMPAR) trafficking has emerged as a fundamental concept for understanding mechanisms of learning and memory as well as many neurological disorders. Classical conditioning is a simple and highly conserved form of associative learning. Our studies use an ex vivo brainstem preparation in which to study cel...

journal_title：Neuroscience letters

authors： Keifer J,Tiwari NK,Buse L,Zheng Z

更新日期：2017-04-03 00:00:00

abstract：:There is evidence indicating that the brain's dopaminergic system is involved in age-associated memory impairment. However, specific roles in this process for the different dopamine receptor subtypes have not been elucidated. The cAMP-response element binding protein (CREB) is one of the cellular molecules that have b...

journal_title：Neuroscience letters

authors： Xing B,Meng X,Wei S,Li S

更新日期：2010-09-13 00:00:00

abstract：:Hippocampal choline acetyltransferase was reduced by 89% in rats two weeks after electrolytic lesion of the septum. The hippocampal concentrations of somatostatin (SOM)-14, SOM-28 and high-molecular-weight SOM were unaltered, suggesting that the activity of hippocampal SOM neurones is not influenced by cholinergic aff...

journal_title：Neuroscience letters

authors： Pierotti AR,Simpson J

更新日期：1986-01-30 00:00:00

abstract：:Sertindole has been marketed and offered daily clinical practice only for 9 months in our country, so no data has been its QTc prolongation potential. In the present study, we performed a clinical trial to investigate the effects of sertindole on QTc in patients with schizophrenia. The study comprised 21 patients with...

journal_title：Neuroscience letters

authors： Atmaca M,Yavuzkir M,Mermi O,Topuz M,Kanmaz E,Tezcan E

更新日期：2008-09-05 00:00:00

abstract：:The whole-cell configuration of the patch-clamp technique was applied to porcine pars intermedia cells. A tetrodotoxin-sensitive sodium current was recorded. Three types of calcium current were observed. Depolarizations from a holding potential of 100 mV elicited a transient current (ICaT), whereas depolarizations fro...

journal_title：Neuroscience letters

authors： Taleb O,Trouslard J,Demeneix BA,Feltz P

更新日期：1986-05-06 00:00:00

abstract：:Sciatic axotomy in 2-day-old rats (P2) causes lumbar motoneuron loss, which could be associated with nitric oxide (NO) production. NO may be produced by three isoforms of synthase (NOS): neuronal (nNOS), endothelial (eNOS) and inducible (iNOS). We investigated NOS expression and NO synthesis in the lumbar enlargement ...

journal_title：Neuroscience letters

authors： Rogério F,Teixeira SA,Júnior HJ,Maria CC,Vieira AS,de Rezende AC,Pereira GA,Muscará MN,Langone F

更新日期：2006-10-23 00:00:00

abstract：:The major human neurodegenerative diseases are characterised by ubiquitin-positive intraneuronal inclusions, however the precise nature of the ubiquitin modifications in these structures is unclear. Using a monoclonal antibody specific for Lys63-linked polyubiquitin we have performed the first immunohistochemical anal...

journal_title：Neuroscience letters

authors： Paine S,Bedford L,Thorpe JR,Mayer RJ,Cavey JR,Bajaj N,Sheppard PW,Lowe J,Layfield R

更新日期：2009-09-04 00:00:00

abstract：:The human hypothalamus is at the center of the human limbic system anatomically and physiologically. The hypothalamus plays pivotal roles in controlling autonomic responses and instinctive behaviors such as regulating fear, aggression, learning, feeding behavior, circadian rhythm, and reproductive activities. The deta...

journal_title：Neuroscience letters

authors： Kamali A,Ghazi Sherbaf F,Rahmani F,Khayat-Khoei M,Aein A,Gandhi A,Shah EG,Sair HI,Riascos RF,Esquenazi Y,Zhu JJ,Keser Z,Hasan KM

更新日期：2020-05-29 00:00:00

abstract：:Aggression reflects the psychological and physical behavior that perpetrator intends to harm victim. Initiation of aggression is influenced by the distal factors (e.g. personality) and proximate causes (e.g. affect) of perpetrator. However, few studies explored the brain structural basis of relationship between these ...

journal_title：Neuroscience letters

authors： Zhu X,Wang K,Cao A,Zhang Y,Qiu J

更新日期：2020-01-23 00:00:00

abstract：:Conditioned environmental stimuli are known to be important determinants of drug seeking behavior. c-Fos, the protein product of the protooncogene c-Fos, is expressed in neurons when there are drug-associated cue-induced drug-seeking behaviour. Therefore, its expression could serve as a marker of regional neuronal act...

journal_title：Neuroscience letters

authors： Zhang F,Zhou W,Liu H,Zhu H,Tang S,Lai M,Yang G

更新日期：2005-09-30 00:00:00

abstract：:The structural specificity of alpha-PMTX, a novel peptide toxin derived from wasp venom has been studied on the neuromuscular synapse in the walking leg of the lobster. alpha-PMTX is known to induce repetitive action potentials in the presynaptic axon due to sodium channel inactivation. We synthesized 29 analogs of al...

journal_title：Neuroscience letters

authors： Konno K,Hisada M,Naoki H,Itagaki Y,Yasuhara T,Nakata Y,Miwa A,Kawai N

更新日期：2000-05-05 00:00:00

abstract：:Local cerebral glucose utilization (LCGU) was measured during spontaneous waking and slow wave sleep (SWS) by an adaptation of the [14C]deoxyglucose method to the free moving cat. In awake animals heterogeneous rates of LCGU were observed throughout the brain with values extending from 8 mumol x 100 g-1 x min-1 for wh...

journal_title：Neuroscience letters

authors： Petitjean F,Seguin S,Des Rosiers MH,Salvert D,Buda C,Janin M,Debilly G,Jouvet M,Bobillier P

更新日期：1982-09-20 00:00:00

abstract：:Galanin (GAL) is distributed in sympathetic nerves in the cat, and exogenous GAL inhibits cardiac vagal action and lowers blood pressure in this species. This study on anaesthetised cats compares the effects on cardiac vagal action and blood pressure of human, rat and porcine GAL. Human GAL has only recently been sequ...

journal_title：Neuroscience letters

authors： Ulman LG,Evans HF,Iismaa TP,Potter EK,McCloskey DI,Shine J

更新日期：1992-02-17 00:00:00

abstract：:The melanocortin receptor type 2 (MC2R or adrenocorticotropic hormone, ACTH receptor) gene (MC2R) encodes a protein involved in regulation of adrenal cortisol secretion, important in the physiological response to stressors. A variant of MC2R, -179A>G, results in reduction of promoter activity and less adrenal action. ...

journal_title：Neuroscience letters

authors： Proudnikov D,Hamon S,Ott J,Kreek MJ

更新日期：2008-04-25 00:00:00

abstract：:The gamma-aminobutyric acid (GABA) antagonist (+/-)-bicuculline inhibits specific [3H]strychnine binding to postsynaptic glycine receptor sites in rat spinal cord synaptosomal membranes with an inhibition constant of about 5 microM, which is fairly similar to its inhibition constant reported for the GABA receptor. Thi...

journal_title：Neuroscience letters

authors： Goldinger A,Müller WE

更新日期：1980-01-01 00:00:00

abstract：:In the experiments described in the present report, we evaluated the effects of ethanol on the activity of GABAA receptors of cerebellar granule cells in culture. Only very high ethanol concentrations (100-300 mM) showed a clear and significant stimulatory effect on the activity of such receptors. This result was unex...

journal_title：Neuroscience letters

authors： Casagrande S,Cupello A,Pellistri F,Robello M

更新日期：2007-03-13 00:00:00

abstract：:The effect of lesions on nerve growth factor receptor (NGFr) immunoreactivity (IR) in motoneurons within the mature feline trigeminal motor nucleus was investigated. Ten days following complete unilateral retrogasserian trigeminal rhizotomy including transection of the trigeminal motor root, motoneurons within the ips...

journal_title：Neuroscience letters

authors： Kullas CD,Henry MA,Westrum LE,Johnson LR,Bothwell M

更新日期：1991-05-27 00:00:00

abstract：:The binding site for 1,4-benzodiazepines in the brain is part of the hetero-oligomeric gamma-aminobutyric acid (GABA)A receptor complex which regulates a chloride ion channel. The presence of the gamma 2 subunit in the complex is necessary for the binding of benzodiazepines to their binding site. This study demonstrat...

journal_title：Neuroscience letters

authors： Karle J,Witt MR,Nielsen M

更新日期：1995-12-29 00:00:00

abstract：:Intracellular regulation of NMDA-receptor-mediated currents in cultured rat spinal dorsal horn neurons was investigated by means of simultaneously recording whole-cell currents and intracellular Ca2+ concentration ([Ca2+]i). During recordings in which EGTA (11 mM) was used to buffer intracellular Ca2+, NMDA currents s...

journal_title：Neuroscience letters

authors： Wang YT,Pak YS,Salter MW

更新日期：1993-07-23 00:00:00