Abstract:
:The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indoles tested (i.e., 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, serotonin, N-acetylserotonin, tryptamine, 5-methoxytryptamine) were less potent than melatonin to impair fast axonal flow. Vinblastine injected either into the ganglion or in the sciatic nerve markedly inhibited axonal transport.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Prevedello MR,Ritta MN,Cardinali DPdoi
10.1016/0304-3940(79)90070-3subject
Has Abstractpub_date
1979-06-01 00:00:00pages
29-34issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(79)90070-3journal_volume
13pub_type
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