Age-related changes in histamine receptor mRNA levels in the mouse brain.

Abstract:

:Several lines of evidence indicate that the histaminergic (HA) system is important for wakefulness and behavioral state regulation. We investigated the hypothesis that age-related changes in HA system occur which may be related to decreased alertness in aging. Although histidine decarboxylase mRNA levels did not change with age in C57BL/6 mice, significant differences were found in histamine H1 receptor (H1R), histamine H2 receptor (H2R), and histamine H3 receptor (H3R) mRNA levels in several brain regions. The most widespread changes were observed in H1R mRNA, which were significantly lower (27-38%) in the cortex, hypothalamus, hippocampus and medulla of 24-month-old mice relative to 3-month-old animals. Age-related changes in H2R mRNA levels were restricted to the pons and cerebellum and decreased H3R mRNA was found only in the medulla. In conjunction with the age-related decrease in hypocretin receptor 2 mRNA levels we have previously reported, decreased HA receptor mRNA levels may contribute to diminished alertness, sleep continuity, and diurnal rhythms of sleep and wakefulness in the aged.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Terao A,Steininger TL,Morairty SR,Kilduff TS

doi

10.1016/j.neulet.2003.10.061

keywords:

subject

Has Abstract

pub_date

2004-01-23 00:00:00

pages

81-4

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

S0304394003012643

journal_volume

355

pub_type

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