Abstract:
:Several lines of evidence indicate that the histaminergic (HA) system is important for wakefulness and behavioral state regulation. We investigated the hypothesis that age-related changes in HA system occur which may be related to decreased alertness in aging. Although histidine decarboxylase mRNA levels did not change with age in C57BL/6 mice, significant differences were found in histamine H1 receptor (H1R), histamine H2 receptor (H2R), and histamine H3 receptor (H3R) mRNA levels in several brain regions. The most widespread changes were observed in H1R mRNA, which were significantly lower (27-38%) in the cortex, hypothalamus, hippocampus and medulla of 24-month-old mice relative to 3-month-old animals. Age-related changes in H2R mRNA levels were restricted to the pons and cerebellum and decreased H3R mRNA was found only in the medulla. In conjunction with the age-related decrease in hypocretin receptor 2 mRNA levels we have previously reported, decreased HA receptor mRNA levels may contribute to diminished alertness, sleep continuity, and diurnal rhythms of sleep and wakefulness in the aged.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Terao A,Steininger TL,Morairty SR,Kilduff TSdoi
10.1016/j.neulet.2003.10.061keywords:
subject
Has Abstractpub_date
2004-01-23 00:00:00pages
81-4issue
1-2eissn
0304-3940issn
1872-7972pii
S0304394003012643journal_volume
355pub_type
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