Abstract:
:The effects of treadmill exercise training on prepro-galanin (GAL) and tyrosine hydroxylase (TH) gene expression in the locus coeruleus (LC) were examined. Male Fischer-344 rats (n=9) were assigned to 6 weeks of treadmill running. An additional group of animals comprised the sedentary home cage control group (n=9). Levels of GAL and TH messenger RNA (mRNA) in the LC were measured using in situ hybridization histochemistry with autoradiography. Levels of GAL mRNA were higher in treadmill trained animals compared to sedentary animals, but there was no effect of treadmill running on TH mRNA. These results suggest that gene expression for galanin is responsive to repeated exercise stress and may have a neuromodulatory role in LC-noradrenergic adaptation to treadmill exercise training.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
O'Neal HA,Van Hoomissen JD,Holmes PV,Dishman RKdoi
10.1016/s0304-3940(00)01780-8keywords:
subject
Has Abstractpub_date
2001-02-16 00:00:00pages
69-72issue
1-2eissn
0304-3940issn
1872-7972pii
S0304394000017808journal_volume
299pub_type
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