Abstract:
:Using immunohistochemical techniques, we demonstrate aspartate aminotransferase (AAT)-like immunoreactivity in cone pedicles and ganglion cells of the cat retina. An identical pattern was seen when we stained for cytochrome oxidase activity, a marker for neurons which have a high metabolic activity. Tetrodotoxin selectively blocked the cytochrome oxidase labeling of ganglion cells. AAT is a key enzyme in the metabolism of aspartate and glutamate and has been proposed as a marker for neurons which use aspartate/glutamate as a neurotransmitter. Due to the close correlation between AAT-like immunoreactivity and cytochrome oxidase activity, we suggest that, at least in the retina, AAT-like immunoreactivity in fact labels cells which have a high metabolic activity.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Bolz J,Thier P,Brecha Ndoi
10.1016/0304-3940(85)90557-9subject
Has Abstractpub_date
1985-02-04 00:00:00pages
315-20issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(85)90557-9journal_volume
53pub_type
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