Localization of aspartate aminotransferase and cytochrome oxidase in the cat retina.

Abstract:

:Using immunohistochemical techniques, we demonstrate aspartate aminotransferase (AAT)-like immunoreactivity in cone pedicles and ganglion cells of the cat retina. An identical pattern was seen when we stained for cytochrome oxidase activity, a marker for neurons which have a high metabolic activity. Tetrodotoxin selectively blocked the cytochrome oxidase labeling of ganglion cells. AAT is a key enzyme in the metabolism of aspartate and glutamate and has been proposed as a marker for neurons which use aspartate/glutamate as a neurotransmitter. Due to the close correlation between AAT-like immunoreactivity and cytochrome oxidase activity, we suggest that, at least in the retina, AAT-like immunoreactivity in fact labels cells which have a high metabolic activity.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Bolz J,Thier P,Brecha N

doi

10.1016/0304-3940(85)90557-9

subject

Has Abstract

pub_date

1985-02-04 00:00:00

pages

315-20

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(85)90557-9

journal_volume

53

pub_type

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