Abstract:
:Our previous work has shown that repetitive stimulation of Adelta-fibers depresses long-term potentiation (LTP) of C-fiber evoked field potentials in spinal dorsal horn. Here, we tested the effects of the Adelta stimulation on the spinal LTP at different time points following LTP induction. Fifteen minutes after LTP induction Adelta stimulation depressed LTP by 44.1+/-4.2% (mean+/-SEM, n=7) for 69.3+/-18.5 min and 1 h after LTP the same Adelta stimulation depressed spinal LTP by only 16.9+/-3.1% for 21.9+/-2.0 min (n=7). Three hours after LTP, however, the Adelta stimulation produced a further potentiation (31.9+/-6.3%, n=7) lasting for all the recording periods (1-3 h). These data indicate that the effects of repetitive stimulation of Adelta-fibers on established spinal LTP of C-fiber evoked field potentials is time-dependent.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Zhang HM,Qi YJ,Xiang XY,Zhang T,Liu XGdoi
10.1016/s0304-3940(01)02343-6keywords:
subject
Has Abstractpub_date
2001-11-23 00:00:00pages
81-4issue
1-2eissn
0304-3940issn
1872-7972pii
S0304394001023436journal_volume
315pub_type
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