Time-dependent plasticity of synaptic transmission produced by long-term potentiation of C-fiber evoked field potentials in rat spinal dorsal horn.

Abstract:

:Our previous work has shown that repetitive stimulation of Adelta-fibers depresses long-term potentiation (LTP) of C-fiber evoked field potentials in spinal dorsal horn. Here, we tested the effects of the Adelta stimulation on the spinal LTP at different time points following LTP induction. Fifteen minutes after LTP induction Adelta stimulation depressed LTP by 44.1+/-4.2% (mean+/-SEM, n=7) for 69.3+/-18.5 min and 1 h after LTP the same Adelta stimulation depressed spinal LTP by only 16.9+/-3.1% for 21.9+/-2.0 min (n=7). Three hours after LTP, however, the Adelta stimulation produced a further potentiation (31.9+/-6.3%, n=7) lasting for all the recording periods (1-3 h). These data indicate that the effects of repetitive stimulation of Adelta-fibers on established spinal LTP of C-fiber evoked field potentials is time-dependent.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Zhang HM,Qi YJ,Xiang XY,Zhang T,Liu XG

doi

10.1016/s0304-3940(01)02343-6

keywords:

subject

Has Abstract

pub_date

2001-11-23 00:00:00

pages

81-4

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

S0304394001023436

journal_volume

315

pub_type

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