The effect of experimentally induced diabetes mellitus on the lipid order and composition of rat cerebral microvessels.

abstract：:Tripeptidyl peptidase-I (TPP-I) is a lysosomal exopeptidase which removes tripeptides from the N-terminus of small proteins. Mutations in the TPP-I gene result in a lethal neurodegenerative disease, late infantile neuronal ceroid lipofuscinosis. The pathological consequences of loss of activity are only manifested in ...

journal_title：Neuroscience letters

authors： Warburton MJ,Bernardini F

更新日期：2002-10-11 00:00:00

abstract：:We investigated the role of 5-HT(2A) and 5-HT(2C) receptors in atypical absence seizures (AAS) induced by trans-1,4-bis[2-chloro-benzylaminomethyl] cyclohexane, dihydrocholoride (AY-9944). The total duration and number and mean duration of the spontaneous bursts of slow spike-and-wave discharges (SSWD) that characteri...

journal_title：Neuroscience letters

authors： Bercovici E,Cortez MA,Snead OC 3rd

更新日期：2007-05-11 00:00:00

abstract：:NCB-20 cells expressed m1- and m4-muscarinic acetylcholine receptor (mAChR) mRNAs, while NG108-15 cells expressed only m4-mAChR mRNA. Butyrate induced a time-dependent increase in the level of m1-mAChR mRNA with no change in the m4-mAChR mRNA level in NCB-20 cells. Similarly, butyrate did not affect the m4-mAChR mRNA ...

journal_title：Neuroscience letters

authors： Fukamauchi F,Mataga N,Wang YJ,Chuang DM

更新日期：1996-07-05 00:00:00

abstract：:This study compared the immediate and prolonged effects of acute bouts of active and passive leg cycling on the soleus H-reflex among 12 young healthy men. The soleus H-reflex was measured immediately before and then 10 and 30 min after 20 min of active, unloaded leg cycling, passively induced leg cycling, and quiet r...

journal_title：Neuroscience letters

authors： Motl RW,Knowles BD,Dishman RK

更新日期：2003-08-21 00:00:00

abstract：:The homozygous Brattleboro rat (di/di) synthesizes a vasopressin (VP) precursor with an aberrant C-terminus, which causes a hypothalamic form of diabetes insipidus. The neuroendocrine polypeptide 7B2 is present in VP and oxytocin (OT) neurons of the supraoptic and paraventricular nucleus of the hypothalamus in wild ty...

journal_title：Neuroscience letters

authors： Gabreëls BA,Verwer RW,Sonnemans MA,Sluiter AA,Ang CW,van Leeuwen FW

更新日期：1997-12-12 00:00:00

abstract：:The influence of the medial prefrontal cortex (PFC) on mesolimbic dopamine activity was studied with electrophysiological techniques and in vivo voltammetry in the chloral hydrate-anesthetized male rat. Glutamate injected into the PFC selectively increased burst firing of single dopamine cells in the ventral tegmental...

journal_title：Neuroscience letters

authors： Murase S,Grenhoff J,Chouvet G,Gonon FG,Svensson TH

更新日期：1993-07-09 00:00:00

abstract：:The structural specificity of alpha-PMTX, a novel peptide toxin derived from wasp venom has been studied on the neuromuscular synapse in the walking leg of the lobster. alpha-PMTX is known to induce repetitive action potentials in the presynaptic axon due to sodium channel inactivation. We synthesized 29 analogs of al...

journal_title：Neuroscience letters

authors： Konno K,Hisada M,Naoki H,Itagaki Y,Yasuhara T,Nakata Y,Miwa A,Kawai N

更新日期：2000-05-05 00:00:00

abstract：:The neural mechanisms of low back pain (LBP) are still enigmatic. Presently, low back muscles are being discussed as an important source of LBP. Here, the neuroanatomical pathway of the nociceptive information from the caudal multifidus muscle (MF) was studied. True blue was injected into the MF at the level L5 to vis...

journal_title：Neuroscience letters

authors： Taguchi T,John V,Hoheisel U,Mense S

更新日期：2007-10-29 00:00:00

abstract：:We investigated the behavior of short-lasting beta bursts (beta rebound, beta ERS) induced after imagination of hand, foot or tongue movement. Nine able-bodied subjects were asked to imagine one type of movement following the presentation of a visual cue stimulus. EEG was recorded from 60 closely spaced electrodes pla...

journal_title：Neuroscience letters

authors： Pfurtscheller G,Neuper C,Brunner C,da Silva FL

更新日期：2005-04-22 00:00:00

abstract：:Rehabilitation is a process which favors recovery after brain damage involving motor systems, and neural plasticity is the only real resource the brain has for inducing neurobiological events in order to bring about re-adaptation. Rats were placed on a treadmill and made to walk, in different groups, at different velo...

journal_title：Neuroscience letters

authors： Vázquez-Hernández N,González-Tapia DC,Martínez-Torres NI,González-Tapia D,González-Burgos I

更新日期：2017-09-14 00:00:00

abstract：:Adenosine has been implicated in the regulation of rapid eye movement sleep (REMS). In an attempt to understand the mechanism of production of adenosine in relation to REMS it was hypothesized that should it be involved in REMS, the latter's deprivation is likely to affect its synthetic machinery. Hence, male albino r...

journal_title：Neuroscience letters

authors： Thakkar M,Mallick BN

更新日期：1996-03-15 00:00:00

abstract：:The Calyx of Held (CoH) synapse is the largest synapse in mammals. It is located in the medial nucleus of the trapezoid body (MNTB) and forms part of the auditory pathway. Modest GABAergic signaling is present in the CoH before hearing onset, when glutamatergic transmission predominates. In mice, after postnatal day 1...

journal_title：Neuroscience letters

authors： Reyes-Haro D,Rosas-Arellano A,González-González MA,Mora-Loyola E,Miledi R,Martínez-Torres A

更新日期：2013-01-04 00:00:00

abstract：:DSP-4[N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride] is a neurotoxin that depletes norepinephrine. The catecholaminergic system has been implicated in the regulation of blood glucose level. In the present study, the effect of DSP-4 administered intracerebroventricularly (i.c.v.) or intrathecally (i.t.) on...

journal_title：Neuroscience letters

authors： Park SH,Kim SS,Lee JR,Sharma N,Suh HW

更新日期：2016-05-04 00:00:00

abstract：:Light microscopic autoradiographic localization of specific recognition sites for thyrotropin-releasing hormone (TRH) was determined on thin sections of rat brain using the potent analogue [3H](3-Me-His2)-TRH ([3H]MeTRH). Microdensitometric analysis of the relative optical densities of TRH receptor labelling revealed ...

journal_title：Neuroscience letters

authors： Sharif NA,Burt DR

更新日期：1985-10-10 00:00:00

abstract：:Unilateral intraplantar injections (1/day for 3 days) of 4 mu g nerve growth factor (NGF) into the rat hindpaw increased the expression of prepro-tachykinin (PPT)- and prepro-calcitonin gene-related peptide (ppCGRP)-mRNA in bilateral L5 dorsal root ganglia (DRGs). This was accompanied by an increase of CGRP-like immun...

journal_title：Neuroscience letters

authors： Amann R,Sirinathsinghji DJ,Donnerer J,Liebmann I,Schuligoi R

更新日期：1996-01-26 00:00:00

abstract：:Following iontophoretic injections of the retrograde tracer Fluoro-gold into the rat locus coeruleus (LC), retrogradely labeled neurons were seen predominantly in the area of C1 adrenergic neurons in the ventrolateral medulla (nucleus paragigantocellularis; PGi) and in the area of C3 adrenergic neurons in the dorsomed...

journal_title：Neuroscience letters

authors： Pieribone VA,Aston-Jones G,Bohn MC

更新日期：1988-03-10 00:00:00

abstract：:Rat dorsal root ganglion neurons can be classified into at least three distinct groups based on cell size, afferent fiber diameter, electrophysiological properties, sensitivity to vanilloid agonists such as capsaicin, and function. In the present study, ATP-activated current in these neurons was characterized using wh...

journal_title：Neuroscience letters

authors： Li C,Peoples RW,Lanthorn TH,Li ZW,Weight FF

更新日期：1999-03-19 00:00:00

abstract：:Previous studies from our team have shown that a 12 month ethanol administration induced deficits in a sequential alternation task, whereas a 6 month treatment had no effects. We have already shown that the 12 month treatment induced deficits both in diencephalic and hippocampal structures, whereas the 6 month treatme...

journal_title：Neuroscience letters

authors： Beracochea D,Jaffard R

更新日期：1991-12-16 00:00:00

abstract：:The cerebellar Purkinje cell is a major site for neurosteroid formation. We have demonstrated recently that the Purkinje cell actively produces sex steroids, such as estradiol and progesterone, de novo from cholesterol only during rat neonatal life, when cerebellar cortical formation occurs. We have further demonstrat...

journal_title：Neuroscience letters

authors： Shikimi H,Sakamoto H,Mezaki Y,Ukena K,Tsutsui K

更新日期：2004-07-01 00:00:00

abstract：:Rabbit retinal Müller cells were isolated by means of papaine and mechanical dissociation. These cells were shown to have a well preserved morphology and to preserve viability for many hours. Intense wheat germ agglutinin binding occurs on the photoreceptor side of Müller cells, especially in the microvillous region. ...

journal_title：Neuroscience letters

authors： Reichenbach A,Dettmer D,Brückner G,Neumann M,Birkenmeyer G

更新日期：1985-03-22 00:00:00

abstract：:Apolipoprotein(a) [apo(a)] is a highly polymorphic glycoprotein which has been suggested to play a role in Alzheimer's disease (AD). Plasma lipoprotein(a) [Lp(a)] levels and the differential expression of apo(a) isoforms were analyzed in 73 sporadic AD patients compared with 73 age- and gender-matched healthy controls...

journal_title：Neuroscience letters

authors： Emanuele E,Peros E,Tomaino C,Feudatari E,Bernardi L,Binetti G,Maletta R,D'Angelo A,Montagna L,Bruni AC,Geroldi D

更新日期：2004-02-26 00:00:00

abstract：:Viral infections are frequently found in opioid addicts, subjecting them to immune challenge. However, the effects of immune challenge on opioid withdrawal are not fully understood. In the present study, mice were intraperitoneally injected with 2mg/kg polyinosinic-polycytidylic acid (Poly I:C, a viral mimetic) for 3 ...

journal_title：Neuroscience letters

authors： Chen L,Zhai H,Lu L,Chen S,Ning Y,Wang W

更新日期：2011-01-10 00:00:00

abstract：:The degree of contamination by blood in macroscopically clear cerebrospinal fluid (CSF) from the rat was assessed by the red blood cell count. Amino acid concentrations in the same samples were determined using high performance liquid chromatography. A significant positive correlation between the number of erythrocyte...

journal_title：Neuroscience letters

authors： Kornhuber ME,Kornhuber J,Kornhuber AW,Hartmann GM

更新日期：1986-08-29 00:00:00

abstract：:The presence of an inhibitor of guanine deaminase in the 'heavy' mito-chondrial fractions of rat brain homogenates has been reported. The results of the present study, using brain homogenates from normal infants who died between ages 1-6 months, low birth weight infants who were brain damaged and died between ages 2 d...

journal_title：Neuroscience letters

authors： Kumar S,Rathi M

更新日期：1976-10-01 00:00:00

abstract：OBJECTIVE:To investigate the protective effect of gliclazide and the role of dynamin-related protein l (Drp-1)-mediated oxidative stress and apoptosis in diabetic peripheral neuropathy (DPN). METHODS:Diabetic rats developed through intra-peritoneal injection of streptozotocin were randomly assigned to treatment group ...

journal_title：Neuroscience letters

authors： Wu YB,Shi LL,Wu YJ,Xu WH,Wang L,Ren MS

更新日期：2012-08-08 00:00:00

abstract：:The aim of the present study is to investigate the effects of orphanin FQ (OFQ) microinjected into the nucleus raphe magnus (NRM) and the nucleus reticularis gigantocellularis (NGC) on pain modulation. The tail-flick latency (TFL) was used as a behavioral index of nociceptive responsiveness. The result showed microinj...

journal_title：Neuroscience letters

authors： Yang Z,Zhang Y,Wu G

更新日期：2001-06-22 00:00:00

abstract：:Divalent metals such as cobalt are frequently used by neurophysiologists to prevent synaptic transmission, because they are thought to selectively block presynaptic calcium conductance. Recording intracellularly from hippocampal CA3 pyramidal cells we show that Co2+ (2 mM) is not specific in this action but also dimin...

journal_title：Neuroscience letters

authors： Gerber U,Gähwiler BH

更新日期：1991-12-16 00:00:00

abstract：:Imagining a familiar environment is different from imagining an environmental map and clinical evidence demonstrated the existence of double dissociations in brain-damaged patients due to the contents of mental images. Here, we assessed a large sample of young and old participants by considering their ability to gener...

journal_title：Neuroscience letters

authors： Piccardi L,Nori R,Palermo L,Guariglia C,Giusberti F

更新日期：2015-08-18 00:00:00

abstract：:Cortical cells in primary culture contain active proteolytic enzymes capable of cleaving nociceptin/orphanin FQ (N/OFQ) and dynorphins to shorter, bioactive fragments. Cells were divided into subpopulations (neurons, astrocytes and oligodendrocytes), and the metabolic pathways in particular populations of the cells we...

journal_title：Neuroscience letters

authors： Suder P,Bogusiewicz A,Rolka K,Laidler P,Kotlinska J,Silberring J

更新日期：2003-09-18 00:00:00

abstract：:Phencyclidine (PCP) abuse is reaching alarming proportions. PCP has recently been shown to induce hypertensive encephalopathies, microvascular cerebrovasospasm and acute intracerebral hemorrhage. Since we have shown in vitro that cerebral vasospasms induced by PCP could be completely reversed, or prevented, by use of ...

journal_title：Neuroscience letters

authors： Huang QF,Gebrewold A,Altura BT,Altura BM

更新日期：1990-05-18 00:00:00