Stimulation by nerve growth factor of neuropeptide synthesis in the adult rat in vivo: bilateral response to unilateral intraplantar injections.

Abstract:

:Unilateral intraplantar injections (1/day for 3 days) of 4 mu g nerve growth factor (NGF) into the rat hindpaw increased the expression of prepro-tachykinin (PPT)- and prepro-calcitonin gene-related peptide (ppCGRP)-mRNA in bilateral L5 dorsal root ganglia (DRGs). This was accompanied by an increase of CGRP-like immunoreactivity in the ipsi- and contralateral sciatic nerve but by no detectable change of CGRP-IR in other afferents. NGF injections into the skin of one ear or into the plantar side of one forepaw increased CGRP-IR in the respective afferents (trigeminal ganglion, or nerves arising from the brachial plexus, respectively), but had no effect on sciatic CGRP-IR. This suggests that the NGF-induced symmetrical increase of CGRP synthesis in L5 DRGs was not caused by systemic action of NGF, which, therefore, may be a useful tool to further investigate mechanisms which are responsible for contralateral effects of unilateral inflammation.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Amann R,Sirinathsinghji DJ,Donnerer J,Liebmann I,Schuligoi R

doi

10.1016/0304-3940(95)12287-7

subject

Has Abstract

pub_date

1996-01-26 00:00:00

pages

171-4

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304394095122877

journal_volume

203

pub_type

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