Abstract:
:Unilateral intraplantar injections (1/day for 3 days) of 4 mu g nerve growth factor (NGF) into the rat hindpaw increased the expression of prepro-tachykinin (PPT)- and prepro-calcitonin gene-related peptide (ppCGRP)-mRNA in bilateral L5 dorsal root ganglia (DRGs). This was accompanied by an increase of CGRP-like immunoreactivity in the ipsi- and contralateral sciatic nerve but by no detectable change of CGRP-IR in other afferents. NGF injections into the skin of one ear or into the plantar side of one forepaw increased CGRP-IR in the respective afferents (trigeminal ganglion, or nerves arising from the brachial plexus, respectively), but had no effect on sciatic CGRP-IR. This suggests that the NGF-induced symmetrical increase of CGRP synthesis in L5 DRGs was not caused by systemic action of NGF, which, therefore, may be a useful tool to further investigate mechanisms which are responsible for contralateral effects of unilateral inflammation.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Amann R,Sirinathsinghji DJ,Donnerer J,Liebmann I,Schuligoi Rdoi
10.1016/0304-3940(95)12287-7subject
Has Abstractpub_date
1996-01-26 00:00:00pages
171-4issue
3eissn
0304-3940issn
1872-7972pii
0304394095122877journal_volume
203pub_type
杂志文章abstract::Electrical stimulation (20-35 Hz, 2-5 V, 1.5 h) of the pelvic nerve in urethane-anesthetized rats increased the expression of c-fos protein-immunoreactivity primarily in neurons in the L6-S1 segments of the spinal cord. The neurons were localized to areas receiving afferent input from the pelvic viscera including the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90459-7
更新日期:1991-08-19 00:00:00
abstract::Long-term repeated application of morphine induces plasticity changes in sensitive neurons, which represents the neurobiological basis of morphine addiction. Caveolin-1 (Cav-1) is an important scaffolding protein that plays a key role in the regulation of neurostructural plasticity. However, in-depth studies focused o...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.11.033
更新日期:2018-02-05 00:00:00
abstract::By using intracellular deposition of horseradish peroxidase (HRP), a method has been designed for combined light and electron microscopic tracing of single fibers and synaptic terminals, belonging to physiologically characterized neurons. This technique has been successfully tested on the axon collateral systems of ca...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(76)90165-8
更新日期:1976-08-01 00:00:00
abstract::It is well known that spinal glia plays a key role in the pathogenesis of pain. The present study was designed to determine the roles of spinal microglia in bee venom-induced persistent spontaneous nociception (PSN), mechanical hyperalgesia and inflammation. We determined the effects of microglia inhibitor minocycline...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.11.028
更新日期:2013-02-08 00:00:00
abstract::Optic fibre regeneration in young Xenopus was studied by [(3)H]proline autoradiography and by mapping the visuotectal projection electrophysiologically from 5 to 210 days after sectioning the right optic nerve. Regenerated optic fibers were demonstrated morphologically both in the contra and ipsilateral tecta. In cont...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(78)90114-3
更新日期:1978-01-01 00:00:00
abstract::Age-related decline in plantar-surface sensitivity has been cited as one of the reasons for balance problems in older adults. This study investigated the level of plantar-surface sensitivity in older adults compared to young adults. Additionally, this study attempted to identify the onset age of advanced insensitivity...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.08.060
更新日期:2006-01-09 00:00:00
abstract::The electron microscopic findings in cats after complete interruption of all afferents to caudate nucleus as well as of its efferent fibers, suggest that the type IX synapses, the presynaptic component of which contains large empty round vesicles, are formed by the axon terminals of intrinsic neurons. They make synapt...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(77)90033-7
更新日期:1977-07-01 00:00:00
abstract::The aim of the present study is to show that the sensorimotor system makes a differential use of visual and internal (proprioception and efferent copy) signals when evaluating either the spatial or the dynamical components of our own motor response carried out under a remote visual feedback. Subjects were required to ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.05.063
更新日期:2005-09-23 00:00:00
abstract::Almost all mechanoreceptive neurons in the cortical taste area (CTA) of the rat had receptive fields (RFs) in the oral cavity, except for a few neurons at the border with the primary somatosensory area that had RFs on the contralateral rhinarium or upper lip. About one-third of the mechanoreceptive neurons with RFs in...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00099-x
更新日期:2002-04-05 00:00:00
abstract::Interaction of beta-adrenergic and somatostatinergic systems in the hippocampus has not been investigated fully. We studied the influence of DL-isoproterenol (ISO), a beta-adrenergic agonist and DL-propranolol (PRO), a beta-adrenergic blocking agent, on the somatostatinergic system in the rat hippocampus. The short-(5...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90701-3
更新日期:1994-01-03 00:00:00
abstract::As the pre-dementia phase of Alzheimer disease, mild cognitive impairment (MCI) involves the onset and development of cognitive impairments. Opioid receptors play pivotal roles in the regulation of learning and cognition. Our study focused on the association of OPRK1 and OPRM1 methylation with MCI in Xinjiang Uygur an...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.11.018
更新日期:2017-01-01 00:00:00
abstract::A trait locus for electroencephalographic photoparoxysmal response (PPR) has been mapped to the chromosomal region 6p21 near a susceptibility locus for juvenile myoclonic epilepsy (JME). Linkage disequilibrium mapping revealed strong associations between JME and polymorphisms of the gene encoding the bromodomain-conta...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.02.026
更新日期:2006-05-29 00:00:00
abstract::Cdk5 (cyclin-dependent kinase 5) is a serine/threonine kinase implicated to play pivotal roles in neuronal development. Recently, its potential involvement as a regulator of neuronal death and survival has attracted considerable interests. Importantly, increasing evidence has linked Cdk5 to the etiopathology of neurod...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2003.12.117
更新日期:2004-05-06 00:00:00
abstract::In micturition control, the roles of ionotropic glutamate (iGlu) receptors NMDA and AMPA are well established, whereas little is known about the function of metabotropic glutamate (mGlu) receptors. Since antagonists for mGlu5 receptors are efficacious in animal models of inflammatory and neuropathic pain, we examined ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.11.026
更新日期:2009-01-23 00:00:00
abstract::Lesch-Nyhan syndrome (LNS), caused by the complete deficiency of hypoxanthine phosphoribosyltransferase (HPRT), is characterized by a neurological deficit, the etiology of which is still unclear. Evidence has accumulated indicating that it reflects dopamine deficiency associated with defective arborization of dopamine...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)01716-5
更新日期:2001-04-27 00:00:00
abstract::The time-variant quadratic phase coupling (QPC) in trace alternant (TA) EEG patterns in healthy full-term neonates (quiet sleep) was investigated by means of time-variant bispectral analysis. The frequency plain 1-1.5 Hz <=> 3.5-4.5 Hz was used as the region-of-interest. QPC rhythms with a frequency of approximately 0...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.05.053
更新日期:2004-10-21 00:00:00
abstract::Fyn-kinase is expressed widely in the entire brain, including the cerebellum. Fyn-kinase-deficient mice are known to exhibit hypersensitivity to ethanol. To evaluate the cerebellar functions of Fyn-kinase, we examined the dynamic characteristics of the horizontal optokinetic response (HOKR) and vestibulo-ocular reflex...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)00779-5
更新日期:2000-02-25 00:00:00
abstract::Huntingtin-associated protein 1 (HAP1) interacts with the product of the Huntington's disease gene. To investigate the function of Hap1 in development and in the adult mouse, we have examined the expression of Hap1 by northern analysis and in situ hybridization histochemistry. Hap1 expression is first detected in the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)00872-7
更新日期:2000-03-17 00:00:00
abstract::Neurons of the rat amygdaloid body were labeled with horseradish peroxidase following its injection into contralateral nuclei of the amygdala. The results strongly suggest that there is a contralateral amygdaloid projection from the basal (dorsal and ventral) nuclei of amygdala; it terminates in the medial, central an...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(81)90416-x
更新日期:1981-10-01 00:00:00
abstract::Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of domestic and wild cervids in North America. To address possible prevention regimens for CWD, we have used a mouse model system and the Rocky Mountain Laboratory (RML) mouse-adapted scrapie prion strain to screen efficacy of potential v...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.10.015
更新日期:2007-12-18 00:00:00
abstract::The cellular prion protein (PrP(C)) is crucial for the development of transmissible spongiform encephalopathies (TSEs), where the pathogenic scrapie isoform (PrP(Sc)) of the same protein, is considered to be the principal or sole infectious agent. Here, we report findings on PrP(C) expression in the rat forebrain, usi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00563-7
更新日期:1999-09-03 00:00:00
abstract::Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in the human diet. Recently, it is demonstrated to have potent antinociceptive effect. However, little is understood about the mechanism underlying CGA analgesia. Here, we have found that CGA can exert an inhibitory effect on the functional activi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.03.027
更新日期:2014-05-01 00:00:00
abstract::The distribution of mRNA coding for a pituitary thyrotropin releasing-hormone (TRH) receptor was examined on sections of spinal cord and lower brainstem of rat using in situ hybridization. Hybridization signals were observed over large neurons in the ventral horn in cervical, thoracic, and lumbar segments of spinal co...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90359-f
更新日期:1992-08-17 00:00:00
abstract::Cerebral ischemia induces rapid efflux of glutamate into the extracellular space contributing to excessive activation of glutamate receptors in postsynaptic cells, particularly N-methyl-D-aspartate (NMDA) receptors, which triggers the neuron lesion through calcium overload. Our studies indicated that cerebral ischemia...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2003.10.076
更新日期:2004-01-30 00:00:00
abstract::FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure of structures relevant to normal language processing. To investigat...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.02.024
更新日期:2011-04-15 00:00:00
abstract::The objective of this study was to test the hypothesis that 4 weeks of lithium administration would be associated with changes in brain gray and white matter volumes in healthy individuals. Thirteen right-handed healthy volunteers (6 females, mean age=25.9+/-10.0 years) were studied. 3D SPGR MRIs (TR=25 ms, TE=5 ms, s...
journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章
doi:10.1016/j.neulet.2007.09.074
更新日期:2007-12-11 00:00:00
abstract::Maternal infection during pregnancy increases the risk of neurodevelopmental conditions such as autism spectrum disorders and schizophrenia in offspring. Several previous animal studies have indicated that maternal immune activation (MIA), rather than a specific pathogen, alters fetal brain development. Among them, pr...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.06.004
更新日期:2017-07-13 00:00:00
abstract::The present study was designed to investigate the role of the interaction of pentobarbital with gamma-aminobutyric acid (GABA)ergic drugs acting on the Cl(-)-adenosine triphosphate (ATP)ase activity of the plasma membranes fraction of bream brain. The preincubation and then incubation of the membranes with pentobarbit...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)01076-5
更新日期:2002-12-16 00:00:00
abstract::Our previous work has shown that repetitive stimulation of Adelta-fibers depresses long-term potentiation (LTP) of C-fiber evoked field potentials in spinal dorsal horn. Here, we tested the effects of the Adelta stimulation on the spinal LTP at different time points following LTP induction. Fifteen minutes after LTP i...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02343-6
更新日期:2001-11-23 00:00:00
abstract::Tyrosine-hydroxylase immunoreactivity is demonstrable by the indirect immunofluorescence technique in a small sub-population of retinal neurones cultured from 2-day-old rabbits. Staining was only weak, restricted to a few neurones, and could not be observed in cultures of less than 10 days. Autoradiographical analysis...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90472-5
更新日期:1984-09-07 00:00:00