Experimental demonstration of intrinsic synapses in cat's caudate nucleus.

abstract：:The changes in extracellular acetylcholine and glutamate levels were determined, during the course of seizures induced by soman, an irreversible inhibitor of acetylcholinesterase, in the CA1 hippocampal area of rats previously injected with atropine or normal saline into septum. The marked increases observed in soman-...

journal_title：Neuroscience letters

authors： Lallement G,Denoyer M,Collet A,Pernot-Marino I,Baubichon D,Monmaur P,Blanchet G

更新日期：1992-05-11 00:00:00

abstract：:Whole-cell patch-clamp recordings (WCR) were made from sympathetic preganglionic neurons (SPN) in neonate rat spinal cord slices. SPN were identified histologically by filling them with the fluorescent dye Lucifer Yellow contained within the patch pipette solution. Current clamp recordings were obtained from SPN with ...

journal_title：Neuroscience letters

authors： Pickering AE,Spanswick D,Logan SD

更新日期：1991-09-16 00:00:00

abstract：:This study reports the solubilization of the rat synaptic vesicle protein SV2A, the brain binding site for the antiepileptic drug levetiracetam (LEV), and its characterization. N-dodecyl-beta-D-maltoside (DDM) was the best detergent at achieving a high percentage of SV2A solubilization and at maintaining the binding c...

journal_title：Neuroscience letters

authors： Lambeng N,Grossmann M,Chatelain P,Fuks B

更新日期：2006-05-01 00:00:00

abstract：:In anesthetized cats selective activation of fine muscle afferents of the hindlimb by KCl or bradykinin (Brad.) induced reflex changes in the urinary bladder. The nature of the reflex responses depended on the functional state of the bladder: they were excitatory when the bladder was quiescent and inhibitory during la...

journal_title：Neuroscience letters

authors： Sato A,Sato Y,Schmidt PF

更新日期：1979-01-01 00:00:00

abstract：:Age-related changes in the brain's saturable, specific, carrier-mediated transport system for the small, N-tyrosinated peptides Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and methionine-enkephalin (Met-Enk) were studied in Fischer 344 rats aged 4 and 26 months. These studies showed statistically significant differences between t...

journal_title：Neuroscience letters

authors： Banks WA,Kastin AJ

更新日期：1985-10-24 00:00:00

abstract：:The affective meaning of words can be quantified statistically by the 'semantic differential technique'. We studied a total of 55 Chinese adults in two experiments: first, 210 nouns were rated by 32 subjects. Factor analysis on these data yielded three independent semantic dimensions. Semantically unique words were us...

journal_title：Neuroscience letters

authors： Skrandies W,Chiu MJ

更新日期：2003-04-24 00:00:00

abstract：:Olprinone, an inhibitor of cyclic nucleotide phosphodiesterase III, inhibited an increase in intracellular Ca(2+) concentrations for acutely dissociated rat hippocampal pyramidal neurons induced by extracellular high K(+) (35 mM) depolarization. Olprinone (100 microM) significantly reduced spontaneous glutamate releas...

journal_title：Neuroscience letters

authors： Fujikawa H,Kanno T,Nagata T,Nishizaki T

更新日期：2008-12-26 00:00:00

abstract：:The localization of amyloid beta protein (A beta), A beta 40, A beta 42, and transthyretin (TTR) was investigated immunohistochemically in the autopsied human kidney, using polyclonal antibodies against TTR, A beta and C-terminal end-specific antibodies against A beta 40 and 42. Immunoreactivities of A beta and A beta...

journal_title：Neuroscience letters

authors： Tsuzuki K,Fukatsu R,Hayashi Y,Yoshida T,Sasaki N,Takamaru Y,Yamaguchi H,Tateno M,Fujii N,Takahata N

更新日期：1997-02-07 00:00:00

abstract：:We present a comprehensive analysis of the change in event-related potential (ERP) due to task difficulty during a visual oddball task. Specifically, we investigated the inter-subject difference in difficulty-related change of ERP patterns using single-trial ERP analysis focusing on P300 and P2 components. ERPs were r...

journal_title：Neuroscience letters

authors： Kim KH,Kim JH,Yoon J,Jung KY

更新日期：2008-11-14 00:00:00

abstract：:Temperature effects on ocular serotonin N-acetyltransferase (NAT) kinetics characteristics from Rana perezi have been studied with respect to tryptamine and serotonin as substrates. Monoamine oxidase (MAO) activity does not interfere in NAT assay at acceptoramine concentrations used in NAT kinetics characterization fr...

journal_title：Neuroscience letters

authors： Alonso-Gómez AL,Alonso-Bedate M,Delgado MJ

更新日期：1993-05-28 00:00:00

abstract：:TRPA1 agonists cinnamaldehyde (CA) and mustard oil (allyl isothiocyanate=AITC) induce heat hyperalgesia and mechanical allodynia in human skin, and sensitize responses of spinal and trigeminal dorsal horn neurons to noxious skin heating in rats. TRPA1 is also implicated in cold nociception. We presently used behaviora...

journal_title：Neuroscience letters

authors： Tsagareli MG,Tsiklauri N,Zanotto KL,Carstens MI,Klein AH,Sawyer CM,Gurtskaia G,Abzianidze E,Carstens E

更新日期：2010-04-12 00:00:00

abstract：:Addicsin is a murine homologue of rat glutamate-transporter-associated protein 3-18 (GTRAP3-18), a putative modulator of neural glutamate-transporter excitatory amino acid carrier 1 (EAAC1). The other molecular functions of addicsin, however, remain largely unknown. We analyzed here the regional and cellular distribut...

journal_title：Neuroscience letters

authors： Inoue K,Akiduki S,Ikemoto MJ

更新日期：2005-10-07 00:00:00

abstract：:The effect of 4-aminopyridine (4-AP) on long-term potentiation (LTP) was studied in the hippocampal slice preparation of the rat. Field excitatory postsynaptic potentials (EPSPs) were recorded and evoked in the stratum radiatum of the CA1. Both the low frequency EPSP and LTP of the EPSP were significantly increased by...

journal_title：Neuroscience letters

authors： Lee WL,Anwyl R,Rowan M

更新日期：1986-09-25 00:00:00

abstract：:This study examined the effect of gestational age of rat ventral mesencephalon (VM) on the characteristics of neurospheres generated from this region and on the yield of each cell type after differentiation of these neurospheres. Neurospheres generated from embryonic day (E) 12 and E13 VM had significantly larger diam...

journal_title：Neuroscience letters

authors： O' Keeffe GW,Sullivan AM

更新日期：2005-02-28 00:00:00

abstract：:We recently described dextran derivatives (RGTA) which stimulate tissue repair in several in vivo models. One of them, RGTA11, has been shown to accelerate crush-induced regeneration and reinnervation of rat EDL and Soleus muscles. In this study we wanted to know if RGTA11 alters the pattern of myosin heavy chain expr...

journal_title：Neuroscience letters

authors： Aamiri A,Butler-Browne GS,Martelly I,Barritault D,Gautron J

更新日期：1995-12-15 00:00:00

abstract：:The localisation of transforming growth factor-beta-2 (TGF-beta 2) in skeletal muscles was investigated with immunohistochemistry. In neonates, TGF-beta 2 was distributed throughout the muscle fibres but as the fibres matured TGF-beta 2 became restricted to the circumference of a small subpopulation of nuclei. These n...

journal_title：Neuroscience letters

authors： McLennan IS,Koishi K

更新日期：1994-08-15 00:00:00

abstract：:DNA fragmentation and activation of caspase-1, implicating involvement of apoptosis, have been reported in the spinal cord of amyotrophic lateral sclerosis (ALS) patients and transgenic mouse models of ALS. Because BH3-only members of the Bcl-2 family have pro-apoptotic activity, we examined the expression of the BH3-...

journal_title：Neuroscience letters

authors： Shinoe T,Wanaka A,Nikaido T,Kanazawa K,Shimizu J,Imaizumi K,Kanazawa I

更新日期：2001-11-09 00:00:00

abstract：:Activin is a member of the transforming growth factor-beta superfamily and affects the viability of hippocampal neurons during postnatal neurogenesis. We used primary hippocampal neuron to study the actions of activin on developing neurons. Continuous treatment of hippocampal cultures with activin suppressed the emerg...

journal_title：Neuroscience letters

authors： Sekiguchi M,Hayashi F,Tsuchida K,Inokuchi K

更新日期：2009-03-20 00:00:00

abstract：:The physiological role of mGluR1-induced inward current in a Purkinje neuron was studied in a cerebellar slice preparation. In a voltage-clamp condition, application of a mGluR1 agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) induced both the transient and sustained phases of inward currents, which were blocked by simu...

journal_title：Neuroscience letters

authors： Yamakawa Y,Hirano T

更新日期：1999-12-24 00:00:00

abstract：:Previously published data have indicated that in the rat, unlike other species examined, the kidney is not supplied by sensory nerves containing substance P (SP). As part of a study of reflex control of renal function in the rat, we have now reassessed this situation. Many fine, varicose, SP-immunoreactive nerve fiber...

journal_title：Neuroscience letters

authors： Ferguson M,Bell C

更新日期：1985-09-30 00:00:00

abstract：:Regular physical activity benefits brain health and function. Physical activity performed by young adults is declining. However, the influence of diminished physical activity on cognitive performance and motor preparation in young adults remains unclear. This study measured changes in behavior and brain activity durin...

journal_title：Neuroscience letters

authors： Cirillo J,Finch JB,Anson JG

更新日期：2017-01-18 00:00:00

abstract：:We carried out an immunohistochemical investigation of the spinal cords of 15 patients with sporadic amyotrophic lateral sclerosis (ALS), using antibodies to inducible nitric oxide synthase (iNOS) and nitrotyrosine; our purpose was to search for a possible role of increased oxidative damage in the motor system that ma...

journal_title：Neuroscience letters

authors： Sasaki S,Shibata N,Komori T,Iwata M

更新日期：2000-09-08 00:00:00

abstract：:The transcriptional regulation of the gene encoding α-synuclein (SNCA) is thought to play a critical role in the pathogenesis of Parkinson's disease (PD), as common genetic variability in this gene is associated with an elevated risk of developing PD. However, the relevant mechanisms are still poorly understood. So fa...

journal_title：Neuroscience letters

authors： Brenner S,Wersinger C,Gasser T

更新日期：2015-07-10 00:00:00

abstract：:Mice exposed to intermittent cold stress (ICS), but not constant cold stress (CCS) showed sustained thermal hyperalgesia for up to 12 days. Systemic or intracerebroventricular (i.c.v.) injection of morphine caused no significant analgesia in ICS mice, but induced dose-dependent analgesia in control mice. However, sign...

journal_title：Neuroscience letters

authors： Nishiyori M,Nagai J,Nakazawa T,Ueda H

更新日期：2010-03-26 00:00:00

abstract：:Preconditioning is a process where a preceding non-lethal form of stress activates a stress response that protects cells against an otherwise lethal form of stress. Preconditioning can be induced in various ways including short-term ischemia or spreading depression. Here we investigated the effect of 1 h repetitive sp...

journal_title：Neuroscience letters

authors： Schneeloch E,Wenkel S,Mies G,Paschen W

更新日期：2004-09-16 00:00:00

abstract：:Parkinson's disease (PD) is defined as a chronic neurodegenerative disorder which is diagnosed mostly by its clinical manifestations. Reactive oxygen species (ROS) are considered as key modulators in the development of PD. Despite the intensive investigations, antioxidant-dependent molecular mechanisms of initiation a...

journal_title：Neuroscience letters

authors： Hemmati-Dinarvand M,Saedi S,Valilo M,Kalantary-Charvadeh A,Alizadeh Sani M,Kargar R,Safari H,Samadi N

更新日期：2019-09-14 00:00:00

abstract：:Optic fibre regeneration in young Xenopus was studied by [(3)H]proline autoradiography and by mapping the visuotectal projection electrophysiologically from 5 to 210 days after sectioning the right optic nerve. Regenerated optic fibers were demonstrated morphologically both in the contra and ipsilateral tecta. In cont...

journal_title：Neuroscience letters

authors： Glastonbury J,Straznicky K

更新日期：1978-01-01 00:00:00

abstract：:Mutations in the glucocerebrosidase (GCase) gene (GBA) and GCase deficiency are major risk factors for Lewy body diseases. Decreased GCase activity enhances alpha-synuclein aggregation and disease development. Lysosomal integral membrane protein type 2, encoded by SCARB2, binds GCase targeting it to lysosomes and tran...

journal_title：Neuroscience letters

authors： Pérez-Roca L,Prada-Dacasa P,Segú-Vergés C,Gámez-Valero A,Serrano-Muñoz MA,Santos C,Beyer K

更新日期：2019-07-27 00:00:00

abstract：:The rodent gustatory cortex is located in the anterior part of the insular cortex, which is near the dorsal part of the rhinal vein (RHV) and the intersection of the anterior and posterior regions of the middle cerebral artery (MCA). Thus, the intersection between the RHV and MCA is used as a landmark for the rodent g...

journal_title：Neuroscience letters

authors： Kida I,Enmi J,Iida H,Yoshioka Y

更新日期：2015-03-04 00:00:00

abstract：:Although first mentions about calcium disturbances in psychiatric diseases appeared more than 30 years ago, the most recent genomic and proteomic findings confirmed a significant role of Ca2+ and Ca2+-regulated pathways in development of neuropathological processes, including bipolar disorder and schizophrenia. Moreov...

journal_title：Neuroscience letters

authors： Lisek M,Boczek T,Zylinska L

更新日期：2018-01-10 00:00:00