Abstract：
:Activin is a member of the transforming growth factor-beta superfamily and affects the viability of hippocampal neurons during postnatal neurogenesis. We used primary hippocampal neuron to study the actions of activin on developing neurons. Continuous treatment of hippocampal cultures with activin suppressed the emergence of GAD67(+) neurons, which are a subtype of GABAergic interneurons, and increased the percentage of Prox1(+) neurons, which are dentate granule cells. The effects of activin were abolished by co-treatment with follistatin, which is a direct inhibitor of activin. In contrast, follistatin treatment alone increased the percentage of GAD67(+) neurons and decreased the percentage of Prox1(+) neurons. These results indicate that changes in activin signaling during postnatal neural development alter the composition of the neural circuitry and suggest that alterations in the ratio of excitatory to inhibitory neurons may be responsible for changes in the spontaneous and evoked-reactivity of these neurons to other neural inputs.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sekiguchi M,Hayashi F,Tsuchida K,Inokuchi Kdoi
10.1016/j.neulet.2009.01.074subject
Has Abstractpub_date
2009-03-20 00:00:00pages
232-7issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(09)00141-4journal_volume
452pub_type
杂志文章abstract：:Abnormalities of cortical representational maps and their plasticity have been described in dystonia. A common polymorphism for BDNF has been associated with abnormal cortical plasticity, and thus might contribute to pathogenesis of dystonia in some subjects. As a first step towards this suggestion, the current study ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.10.059
更新日期：2010-01-01 00:00:00
abstract：:Diabetic peripheral neuropathy (DPN) affects the sensory function of the hands and, consequently, may negatively impact hand dexterity, maximum grip strength (GSMax), and hand grip force (GF) control during object manipulation. The aims of this study were to examine and compare the GF control during a simple holding t...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.08.071
更新日期：2017-10-17 00:00:00
abstract：BACKROUND:A relatively small number of genetic variants are implicated to pathophysiology of intracerebral hemorrhage (ICH). Aquaporin-4 (AQP4) has been reported to be implicated in the pathophysiological processes of ICH development. OBJECTIVE:To examine the role of AQP4 gene region polymorphisms on the ICH risk. ME...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.12.025
更新日期：2019-03-23 00:00:00
abstract：:We used quantitative in situ hybridization to study changes in the expression of c-fos following hypoxic-ischemia (H-I) in the neonatal rat brain. 7-day-old rat pups were subjected to a unilateral ligation of the common carotid artery followed by a 2 h 15 min hypoxic period (7.7% O2 in N2). This resulted in the expect...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90495-2
更新日期：1994-10-24 00:00:00
abstract：:This study assessed the effect of the kappa opioid receptor agonist U50,488 administered into the rat temporomandibular joint (TMJ) on nociceptive behavioral responses evoked by formalin injected into the same site. Groups consisted of females, stratified into proestrus and diestrus phases of the estrous cycle, and ma...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.09.048
更新日期：2004-12-06 00:00:00
abstract：:In the caudal postcentral finger region near or in the anterior bank of the intraparietal sulcus of alert monkeys, we found neurons that were activated selectively by the contact of the hand to certain common objects such as bottle brushes, acrylic plates, parts of the stabilized monkey's chair, etc. All of these neur...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)11302-d
更新日期：1995-02-17 00:00:00
abstract：:In homogenates of rat hippocampus and striatum, but not substantia nigra, somatostatin (SRIF) inhibits forskolin-activated adenylate cyclase in nanomolar concentrations. However, SRIF can also stimulate adenylate cyclase in micromolar concentrations in homogenates of rat hippocampus and substantia nigra. The SRIF octa...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90321-2
更新日期：1989-09-25 00:00:00
abstract：:The study of neural arousal mechanisms has been greatly aided by the discovery of the orexin peptides (orexin A and orexin B), the subsequent identification of the neurons that synthesize these peptides, their projections in the brain, and the distribution of orexin receptors in the central nervous system. Orexin neur...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.10.058
更新日期：2008-12-31 00:00:00
abstract：:There is controversy as to what extent the processing of spectrally rich sounds in the human auditory cortex is related to the processing of singular frequencies. An informative index of the function of the auditory cortex, particularly important in neurological patients, is the mismatch negativity (MMN), a component ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.08.045
更新日期：2003-12-04 00:00:00
abstract：:The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial. The aim of present study was to investigate the association between 5-HTTLPR and 5-HT2C Cys23Ser variants and susceptibility to bipolar I disorder (BID). The 5-HT2C genotypes were stud...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.01.027
更新日期：2015-03-17 00:00:00
abstract：:Adenosine modulates hippocampal synaptic plasticity, namely long-term potentiation (LTP) and long-term depression (LTD), through activation of A1 and A2A receptors. We now report a novel role for the recently described adenosine A3 receptor in the regulation of synaptic plasticity in the CA1 area of hippocampal slices...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)01633-0
更新日期：2001-04-13 00:00:00
abstract：:Circadian changes in cortical acetylcholine (ACh) release were examined in freely moving rats using long-term in vivo microdialysis and high performance liquid chromatography with electrochemical detection. A microdialysis probe was implanted into the frontal cortex and a dialysate was collected every 30 min for two o...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90316-l
更新日期：1991-11-11 00:00:00
abstract：:Neurons within the hypothalamic paraventricular nuclei (PVN) have been antidromically invaded following electrical stimulation within the pons and medulla of rats. These neurones are dispersed throughout the PVN and are often found near neurones antidromically invaded only from the pituitary salk. In addition, a small...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90033-1
更新日期：1981-05-06 00:00:00
abstract：:Inorganic mercury (HgCl2) was administered to adult mice in drinking water (20 mg/l). Animals were sacrificed after one or two years and fixed by whole-body perfusion. Sections of the hypothalamus and neurohypophysis were subjected to silver acetate autometallography for visualization of mercury at light and electron ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00529-7
更新日期：1999-08-20 00:00:00
abstract：:Following peripheral nerve section, the cell body and proximal axon undergo various physiological and morphological changes which may be associated with regrowth. We found that axotomy reduced the amplitude and duration of the afterhyperpolarization (AHP) of the action potential (AP) of bullfrog sympathetic neurones. ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90391-5
更新日期：1986-06-18 00:00:00
abstract：:Protein kinase G (PKG) has been implicated in a variety of physiological functions including synaptic plasticity in the brain. This study investigated the involvement of dopamine D3 (D3) receptors in PKG-regulated dopamine release, long-term changes in gene expression and behavioral sensitization after repeated cocain...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.02.014
更新日期：2013-04-29 00:00:00
abstract：:Following the i.c.v. administration of antivasopressin serum the alpha-MPT-induced disappearance of noradrenaline was decreased in the dorsal septal nucleus, parafascicular nucleus and the rostral part of the nucleus tractus solitarii, whereas that of dopamine was lowered in the caudate nucleus and in the A2 region of...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(79)90058-2
更新日期：1979-01-01 00:00:00
abstract：:In the present study, newborn male Wistar rats were injected, subcutaneously, five times, every other day, with monosodium glutamate (MSG, 4 g/kg bw) or saline (as control, C), during the neonatal period. MSG animals developed destruction of the arcuate nuclei (ARC) with absence of NPY-immunoreactive cell bodies, whic...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.12.043
更新日期：2006-05-01 00:00:00
abstract：:In all mammals so far investigated the occurrence of ponto-geniculo-occipital (PGO) waves precedes the onset and maintenance of desynchronized (D) sleep. As unitary electrographic events, PGO waves provide an index for quantitative evaluation of physiological D sleep or the D sleep-like state evoked by centrally admin...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90269-2
更新日期：1987-12-04 00:00:00
abstract：:Using reverse transcription in combination with the polymerase chain reaction, the developmental expression of neurotrophins in organotypic slice cultures of rat hippocampus was investigated. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) mRNA levels after different time periods in vitro were c...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90711-s
更新日期：1993-06-11 00:00:00
abstract：:PC12 cells, a clonal cell line established from a rat pheochromocytoma, were injected into the subarachnoid space in the lumbar spinal cord of adult rats. These cells invaded the spinal cord as a metastatic tumor and, after 2 weeks, displaced one-third of the cord parenchyma, causing hind limb paralysis. The tumor con...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90437-4
更新日期：1986-09-25 00:00:00
abstract：:Neuronal apoptosis sculpts the developing brain, and nearly all identified classes of neurons seem to be produced "in excess" during development. FoxO transcription factors regulate apoptosis in vitro in deprived of neurotrophins. It is unknown if FoxO3a is involved in the development of neurons. Here, we report a rol...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.07.068
更新日期：2010-10-29 00:00:00
abstract：:The phenylquinoline, PK 8165 (5-25 mg/kg), produced dose-related reductions in locomotor activity, rearing and exploratory head-dipping in a holeboard. Neither Ro 15-1788 (1, 10 or 20 mg/kg) nor CGS 8216 (1 or 10 mg/kg) was able to reverse the reductions in locomotor activity or rearing. This suggests that at least so...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90486-5
更新日期：1984-09-07 00:00:00
abstract：:Muscle fatigue is known to be associated with a deteriorated muscle coordination and impaired movement performance in variety of voluntary movements. The aim of this study was to investigate the generally underexplored effect of muscle fatigue on both the coordination between grip force (GF; the force component perpen...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.07.008
更新日期：2013-08-29 00:00:00
abstract：:The involvement of nitric oxide (NO) in modulation of seizure susceptibility by delta-opioid agonist (+)-4-((alpha R)-alpha-((2S, 5R)-4-allyl-2, 5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N, N-diethyl-benzamide (SNC80) was examined in mice. Systemic administration of SNC80 (0.1-5 mg/kg, intraperitoneally (i.p.)) decre...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)00417-2
更新日期：2002-08-30 00:00:00
abstract：:Current theories of orbitofrontal cortex (OFC) function suggest that this region should participate in the generation of error-related signals associated with the outcomes of actions. We investigated the impact of lesions to OFC on the error-related negativity (ERN), an electrophysiological marker of performance monit...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.05.115
更新日期：2008-08-15 00:00:00
abstract：BACKGROUND:Studies have demonstrated that the failure of oligodendrocyte precursor cells (OPCs) differentiation as a major cause of remyelination failure in demyelinating disease. The reasons for this failure are not completely understood. We hypothesized that the present of myelin debris in CNS play an important role ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2020.134872
更新日期：2020-04-23 00:00:00
abstract：:The association between insulin degrading enzyme (IDE) gene polymorphisms and Alzheimer's disease (AD) risk has been widely reported, but results were somewhat controversial. To assess the association between IDE polymorphisms and AD risk, a meta-analysis was performed. We systematically reviewed relevant studies retr...
journal_title：Neuroscience letters
pub_type： 杂志文章,meta分析
doi：10.1016/j.neulet.2013.01.051
更新日期：2013-04-29 00:00:00
abstract：:Delta9-THC and synthetic cannabinoids produce memory impairment in humans as well as in laboratory animals. The high concentration of cannabinoid CB1 receptors and the presence of endocannabinoids in the hippocampus suggest that a cannabinoid neurochemical system may play a role in learning and memory processes. Thus,...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.01.049
更新日期：2005-06-03 00:00:00
abstract：:Several studies reported that peripheral administration of bombesin (BN) and gastrin-releasing peptide (GRP) improved some forms of memory performance. In the present study, we examined the role of endogenous BN-like peptide(s) for the acquisition of inhibitory avoidance learning in mice using BN-like peptide receptor...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(03)00077-6
更新日期：2003-04-03 00:00:00
