Abstract：
:Several studies reported that peripheral administration of bombesin (BN) and gastrin-releasing peptide (GRP) improved some forms of memory performance. In the present study, we examined the role of endogenous BN-like peptide(s) for the acquisition of inhibitory avoidance learning in mice using BN-like peptide receptor antagonists. An administration of [Leu(13)-(psi-CH(2)NH)-Leu(14)]BN (antagonizes GRP-R>neuromedin B receptor (NMB-R)) impaired the performance of inhibitory avoidance learning in all doses (16, 32, 64 nmol/kg). While the effect was somewhat lesser than [Leu(13)-(psi-CH(2)NH)-Leu(14)]BN, BIM23127 (antagonizes NMB-R>GRP-R) also impaired performance in a moderate dose (32 nmol/kg). These results showed that endogenous BN-like peptides have some role(s) for the modulation of learning and memory, and suggest that NMB/NMB-R pathway may also be involved in the memory acquisition and modulation as well as GRP/GRP-R pathway.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Santo-Yamada Y,Yamada K,Wada E,Goto Y,Wada Kdoi
10.1016/s0304-3940(03)00077-6keywords:
subject
Has Abstractpub_date
2003-04-03 00:00:00pages
65-8issue
1eissn
0304-3940issn
1872-7972pii
S0304394003000776journal_volume
340pub_type
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