Abstract:
:The roles of the endogenous adenosine on acetylcholine release via adenosine A1 receptor were investigated in rat cerebral cortex using brain microdialysis. Oral administration of KF15372 (8-dicyclopropylmethyl-1,3-dipropylxanthine), a novel selective adenosine A1 receptor antagonist, at doses of 1.25, 5, and 20 mg/kg, significantly increased the extracellular levels of acetylcholine in rat cerebral cortex. Selective A1 agonist N6-((R)-phenylisopropyl) adenosine (R-PIA) did not affect the extracellular level of acetylcholine by both oral (1.25 mg/kg) and intracortical administrations (0.3 microM) via dialysis probe. These results suggest that the extracellular level of acetylcholine is under tonic inhibitory control of endogenous adenosine via the A1 receptor.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kurokawa M,Shiozaki S,Nonaka H,Kase H,Nakamura J,Kuwana Ydoi
10.1016/0304-3940(96)12632-xsubject
Has Abstractpub_date
1996-05-17 00:00:00pages
181-4issue
3eissn
0304-3940issn
1872-7972pii
030439409612632Xjournal_volume
209pub_type
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