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Opioid gene expression in rat striatum is modulated via opioid receptors: evidence from localized receptor inactivation.

Abstract：

:The irreversible opiate antagonists beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) were injected into rat striatum. One day later, mu-opioid receptor binding, as assessed by receptor autoradiography, was abolished in the injected striatum, while [3H]spiperone binding remained largely unaffected. In situ hybridization was used to examine possible effects on striatal proenkephalin mRNA and prodynorphin mRNA content. The levels of proenkephalin mRNA were increased ipsilaterally following beta-CNA injection, but were slightly decreased following beta-FNA injection. Prodynorphin mRNA content was also increased by beta-CNA administration. The results provide evidence for a differential modulation of striatal opioid peptide gene expression via distinct opioid receptors.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Morris BJ,Höllt V,Herz A

doi

10.1016/0304-3940(88)90484-3

subject

Has Abstract

pub_date

1988-06-17 00:00:00

pages

80-4

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(88)90484-3

journal_volume

89

pub_type

杂志文章

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