Abstract:
:The diagonal band of Broca (DBB) is involved in cardiovascular control in rats. In the present study, we report the effect of acute and reversible neurotransmission inhibition in the DBB by bilateral microinjection of the nonselective neurotransmission blocker CoCl(2) (1mM, 100 nL) on the cardiac baroreflex response in unanesthetized rats. Local DBB neurotransmission inhibition did not affect baseline values of either blood pressure or heart rate, suggesting no tonic DBB influence on cardiovascular system activity. However, CoCl(2) microinjections enhanced both the reflex bradycardia associated with blood pressure increases caused by i.v. infusion of phenylephrine and tachycardiac response evoked by blood pressure decreases caused by i.v. infusion of sodium nitroprusside. An increase in baroreflex gain was also observed. Baroreflex returned to control values 60 min after CoCl(2) microinjections, confirming its reversible effect. In conclusion, our data suggest that synapses within DBB have a tonic inhibitory influence on both the cardiac parasympathetic and sympathetic components of the baroreflex.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Crestani CC,Tavares RF,Alves FH,Resstel LB,Corrêa FMdoi
10.1016/j.neulet.2008.10.055subject
Has Abstractpub_date
2008-12-26 00:00:00pages
189-93issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(08)01463-8journal_volume
448pub_type
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