Abstract:
:In this study, we investigated the effect of PSD-95 antisense oligodeoxynucleotides on the phosphorylation of MLK3, JNK3 and interactions of MLK3 and PSD-95 with kainate receptor (GluR6) by immunoprecipitation and immunoblotting. Transient (15 min) brain ischemia was induced by the four-vessel occlusion in Sprague-Dawley rats. The antisense oligodeoxynucleotides of PSD-95 were administrated to the SD rats once per day for 3 days before ischemia. Our data show that the antisense oligodeoxynucleotides could inhibit phosphorylation of MLK3 and JNK3 and decrease the interactions of MLK3 and PSD-95 with GluR6. These results indicate that PSD-95 plays an important role in the formation of the GluR6.PSD-95.MLK3 signaling module and MLK3 and JNK3 activation in postischemic rat hippocampus.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Pei DS,Sun YF,Guan QH,Hao ZB,Xu TL,Zhang GYdoi
10.1016/j.neulet.2004.05.082keywords:
subject
Has Abstractpub_date
2004-08-26 00:00:00pages
71-5issue
1eissn
0304-3940issn
1872-7972pii
S0304394004006780journal_volume
367pub_type
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