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Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts.

Abstract：

:The present study shows that cultured fibroblasts from sporadic Alzheimer's disease patients are deficient in protein kinase C-regulated secretion of amyloid precursor protein. In particular, Alzheimer fibroblasts show a reduced basal secretion and a reduced response at low concentrations of phorbol-12,13-dibutyrate, with an EC50 twofold higher than control fibroblasts. Furthermore, we observed that such defective regulation of the amyloid precursor secretion can possibly be correlated to a specific defect in protein kinase C alpha in fibroblasts from Alzheimer patients.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Bergamaschi S,Binetti G,Govoni S,Wetsel WC,Battaini F,Trabucchi M,Bianchetti A,Racchi M

doi

10.1016/0304-3940(95)12168-4

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

1-5

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304394095121684

journal_volume

201

pub_type

杂志文章

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