Macrophages-mediated neurotoxic effects of intra-nigral manganese administration are attenuated by minocycline.

abstract：:The cells of origin of the brainstem projection to the caudate-putamen (CP) were examined in the albino rat by the use of two fluorescent retrograde tracers. Nuclear yellow was injected into the CP of one hemisphere and granular blue was injected into the contralateral CP. Retrogradely labeled cells were studied in th...

journal_title：Neuroscience letters

authors： Loughlin SE,Fallon JH

更新日期：1982-09-20 00:00:00

abstract：:The study was performed to investigate the effects of bradykinin preconditioning on spinal cord ischemic injury using an in vivo transient spinal cord ischemia model in rats. Prior to ischemia, bradykinin was infused continuously via the left femoral artery starting 15min before ischemia. Neurological functions were e...

journal_title：Neuroscience letters

authors： Yan-Feng W,Gang L,Yan-Ting G

更新日期：2008-03-12 00:00:00

abstract：:Low doses of colchicine (greater than 0.5 microgram) injected into the eyes of young chickens irreversibly inhibit axonal transport of material labelled with [3H]fucose. This is due to almost total destruction of the retinal ganglion cells, while other retinal cell types, including the displaced amacrine cells found i...

journal_title：Neuroscience letters

authors： Morgan IG

更新日期：1981-07-17 00:00:00

abstract：:To determine the involvement of the medial prefrontal cortex (mPFC) in operant-type delayed alternation, microinjections of muscimol into the mPFC were used for temporal inactivation during behavioral tests in rats. The temporal mPFC inactivation showed effects related to both dorsal (decreased delay-dependent correct...

journal_title：Neuroscience letters

authors： Izaki Y,Maruki K,Hori K,Nomura M

更新日期：2001-11-27 00:00:00

abstract：:The highest prevalence rate of spinocerebellar ataxia type 6 (SCA6) in the worldwide population is in the Chugoku and Kansai areas of Western Japan, but the reason of this geographic characteristics is unclear. We investigated the predisposing haplotypes and their geographic distribution. Genotyping of five microsatel...

journal_title：Neuroscience letters

authors： Terasawa H,Oda M,Morino H,Miyachi T,Izumi Y,Maruyama H,Matsumoto M,Kawakami H

更新日期：2004-03-25 00:00:00

abstract：:It has been demonstrated that thyroxine deiodinating activity is present in rat pineal gland, and its activity increases significantly during the night time. We have studied whether mRNA for type II iodothyronine deiodinase is expressed in rat pineal gland and whether the nocturnal rise of pineal T4 deiodinating activ...

journal_title：Neuroscience letters

authors： Murakami M,Hosoi Y,Negishi T,Kamiya Y,Ogiwara T,Mizuma H,Yamada M,Iriuchijima T,Mori M

更新日期：1997-05-09 00:00:00

abstract：:The effect of methionine-enkephalin (Met-Enk) on responses of rat brain neostriatum neurones to microiontophoretic application of glutamate was studied in experiments with extracellular recording of spike activity. Met-Enk administered by microiontophoresis was shown to depress the glutamate-induced responses. In para...

journal_title：Neuroscience letters

authors： Kuznetsov VI,Godukhin OV

更新日期：1985-06-12 00:00:00

abstract：:The effect of the metabotropic glutamate receptor (mGluR) antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) was investigated on the induction of long-term potentiation (LTP) of alpha-amino-3-hydroxy-5- methyl-4-isoxazoleproprionate receptor-mediated excitatory postsynaptic currents (epscs) recorded from denta...

journal_title：Neuroscience letters

authors： Wang Y,Rowan MJ,Anwyl R

更新日期：1995-09-15 00:00:00

abstract：:Carrageenan-induced inflammation of the rat hindpaw has been used as a model for persistent pain of inflammatory origin. The induction of inflammation resulting from carrageenan injection in the rat hindpaw has been shown to elicit an increase in the antinociceptive potency of morphine, an effect postulated to be rela...

journal_title：Neuroscience letters

authors： Ossipov MH,Kovelowski CJ,Porreca F

更新日期：1995-01-30 00:00:00

abstract：BACKROUND:8-hydroxy-2 deoxyguanosine (8-OHdG) and the 8-hydroxyguanosine (8-OHG) are the most widely used biomarkers of nucleoside oxidation affecting DNA and RNA and are considered reliable markers of oxidative stress. Increased levels of these markers are found in the various biological fluids of patients with neurod...

journal_title：Neuroscience letters

authors： Gmitterová K,Gawinecka J,Heinemann U,Valkovič P,Zerr I

更新日期：2018-01-01 00:00:00

abstract：:In animal models endogenous cannabinoids have an inhibitory effect on trigeminovascular activation through the cannabinoid receptor 1 (CB1), although there is no evidence of the potential role of CB1 in human migraine. In this study we applied single marker association and haplotypic trend regression analysis to inves...

journal_title：Neuroscience letters

authors： Juhasz G,Lazary J,Chase D,Pegg E,Downey D,Toth ZG,Stones K,Platt H,Mekli K,Payton A,Anderson IM,Deakin JF,Bagdy G

更新日期：2009-09-18 00:00:00

abstract：:Dinucleotide repeat polymorphism has been observed in the promoter of the alpha-synuclein (alpha-SYN)/NAC precursor protein (NACP) gene. Alpha-SYN/NACP allele 3 (described by Xia et al. (Ann. Neurol., 40 (1996) 207), equivalent to allele 1 described by Krüger et al. (Ann. Neurol. 45 (1999) 611) is reported to be signi...

journal_title：Neuroscience letters

authors： Izumi Y,Morino H,Oda M,Maruyama H,Udaka F,Kameyama M,Nakamura S,Kawakami H

更新日期：2001-03-09 00:00:00

abstract：:Intracellular recordings were made from astrocytes of the hippocampal CA1 region in rat slice preparations. A single stimulus at the Schaffer collaterals with high intensities (>/=10 V), but not low intensities (<10 V), induced a slow depolarization similar to the evoked postsynaptic potentials observed in hippocampal...

journal_title：Neuroscience letters

authors： Hattori G,Tanaka E,Yokomizo Y,Shigemori M,Higashi H

更新日期：2003-06-05 00:00:00

abstract：:To investigate the acute effects of whole-body cryotherapy (WBC) on postural control, we measured postural sway (COP) in a quiet stance with eyes open in four consecutive 20-second tests: before and 1, 6 and 11min after the WBC. Twenty-four healthy young subjects aged 19.3±0.9 were exposed to WBC (-110°C) for 2min. Th...

journal_title：Neuroscience letters

authors： Giemza C,Czech P,Paluszak A,Bieć E,Borzucka D,Kuczyński M

更新日期：2013-03-01 00:00:00

abstract：:Dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA) and dehydroascorbic acid (DHAA) levels were determined by HPLC in the striatal synaptosomal fraction and in the whole striatum of rats, whose fronto-parietal cortex had been bilaterally ablated, after a single injection of d-amphetamine (2.0 mg/...

journal_title：Neuroscience letters

authors： Desole MS,Miele M,Enrico P,Fresu L,Esposito G,De Natale G,Miele E

更新日期：1992-05-11 00:00:00

abstract：:This experiment examined the hypothesis that aging reduces the coupling between system components, resulting in a loss of complexity in behavior. Young (18-23 years), old (60-65 years), and older old (70-75 years) subjects performed rhythmical movement and postural tasks with the index finger. Irregularity of the acce...

journal_title：Neuroscience letters

authors： Hong SL,James EG,Newell KM

更新日期：2008-03-12 00:00:00

abstract：:Normal cerebellar tissue, obtained from 15-day-old CBA/JNCij mouse embryos, was transplanted into the cerebellum of 4-week-old weaver mice. At the 6th week after the transplantation, the grafted tissue was distinguishable from the host cerebellum, developing a trilaminar organization. The formation of synapses by the ...

journal_title：Neuroscience letters

authors： Takayama H,Kohsaka S,Shinozaki T,Inoue H,Toya S,Ueda T,Tsukada Y

更新日期：1987-08-31 00:00:00

abstract：:Monosynaptic evoked responses were used to localize dorsal root ganglion (DRG) afferent terminals within organotypic fetal mouse spinal cord explants which had been chronically exposed to purified bovine gangliosides during early development. Ganglioside grown cultures showed a highly significant increase in dorsal co...

journal_title：Neuroscience letters

authors： Baker RE

更新日期：1983-10-31 00:00:00

abstract：:Protein misfolding cyclic amplification (PMCA) is a highly sensitive technique used to detect minute amounts of scrapie prion protein (PrP(Sc)), a major protein component of the infectious agents associated with prion diseases. Although exponential in vitro amplification of hamster scrapie PrP(Sc) has been established...

journal_title：Neuroscience letters

authors： Murayama Y,Yoshioka M,Yokoyama T,Iwamaru Y,Imamura M,Masujin K,Yoshiba S,Mohri S

更新日期：2007-02-21 00:00:00

abstract：:Novel paired ependymal ridges (EPRS) have been identified in the ventrolateral wall of the cerebral aqueduct of the rat. Scanning electron microscopic techniques revealed that the dorsolateral and ventromedial ridges differ from each other in surface morphology. Using the PAP immunohistochemical technique, the EPRS de...

journal_title：Neuroscience letters

authors： Welsh MG,Beitz AJ

更新日期：1981-11-18 00:00:00

abstract：:Estrogen effects on pineal secretion of melatonin are controversial. Some feel that estrogen inhibits melatonin output in vitro but not in vivo. Melatonin levels vary with the age in chickens where circulating estrogen levels also vary. Laying hens have minimal melatonin levels and maximal serum iron concentrations. T...

journal_title：Neuroscience letters

authors： Pablos MI,Agapito MT,Recio JM,Pérez-Gallardo L,Córdova MD,Mori JO

更新日期：1993-09-03 00:00:00

abstract：:Nuclear factor kappa B (NF(kappa)B) transcription factor plays a key role in the expression of many genes involved in the inflammatory process. We used the Freund's Complete Adjuvant (FCA)-induced model of peripheral inflammation to investigate the anti-inflammatory effects of double stranded oligodeoxynucleotides (OD...

journal_title：Neuroscience letters

authors： Igwe OJ

更新日期：2005-06-10 00:00:00

abstract：:Chronic stress results in neurological complications like depression, cognitive dysfunction, and anxiety disorders. In our previous study, we observed that Urtica dioica leaf extract attenuated chronic stress-induced complications. Further, we observed that Urtica dioica contained a great amount of the flavonoid rutin...

journal_title：Neuroscience letters

authors： Parashar A,Mehta V,Udayabanu M

更新日期：2017-08-24 00:00:00

abstract：:The influence of the medial prefrontal cortex (PFC) on mesolimbic dopamine activity was studied with electrophysiological techniques and in vivo voltammetry in the chloral hydrate-anesthetized male rat. Glutamate injected into the PFC selectively increased burst firing of single dopamine cells in the ventral tegmental...

journal_title：Neuroscience letters

authors： Murase S,Grenhoff J,Chouvet G,Gonon FG,Svensson TH

更新日期：1993-07-09 00:00:00

abstract：:Immunolocalization of 14-3-3 protein isoforms in relation to Pick bodies in Pick body disease (PBD) brains was investigated. Weakly granular immunoreactivity of 14-3-3 proteins was found in neurons in control subjects and in Pick body disease brains. In addition to this granular immunoreactivity, many Pick bodies were...

journal_title：Neuroscience letters

authors： Umahara T,Uchihara T,Tsuchiya K,Nakamura A,Ikeda K,Iwamoto T,Takasaki M

更新日期：2004-11-23 00:00:00

abstract：:The pharmacokinetics of 2-amino-7-phosphonoheptanoate (AP7) in rat plasma and appearance in cerebrospinal fluid (CSF) are reported. Using high-performance liquid chromatography (HPLC) with fluorescence detection, concentrations of AP7 can be detected as low as 1.0 microM. Peak CSF concentrations (12-15 microM) for bot...

journal_title：Neuroscience letters

authors： Compton RP,Hood WF,Monahan JB

更新日期：1988-02-03 00:00:00

abstract：:Tau is a neuronal microtubule-associated protein found predominantly in axons. Hyperphosphorylation of tau reduces the stability of microtubules, which may be a pathogenic mechanism in Alzheimer's disease. To understand the different effects between tau and glycogen synthase kinase 3beta (GSK-3beta) phosphorylated tau...

journal_title：Neuroscience letters

authors： Sang H,Lu Z,Li Y,Ru B,Wang W,Chen J

更新日期：2001-10-26 00:00:00

abstract：:Existing literature concerning the effect of experimentally-induced diabetes on pain thresholds in rodent models remains controversial. In this work, we describe a phenotypical switch from streptozotocin-induced pinprick hypoalgesia to hyperalgesia observed in the same laboratory, in the same strain of rats, obtained ...

journal_title：Neuroscience letters

authors： Yadlapalli JSK,Dogra N,Walbaum AW,Prather PL,Crooks PA,Dobretsov M

更新日期：2018-04-23 00:00:00

abstract：:Incorporation of the N-methyl-d-aspartate receptor (NMDAR) subunit NR3A into functional NMDARs results in reduced channel conductance and Ca(2+) permeability. To further investigate the function of NR3A, we have set out to characterize its intracellular binding partners. Here, we report a novel protein interaction bet...

journal_title：Neuroscience letters

authors： Eriksson M,Samuelsson H,Björklund S,Tortosa E,Avila J,Samuelsson EB,Benedikz E,Sundström E

更新日期：2010-05-07 00:00:00

abstract：:Dopamine metabolism and release were determined in the striata of rats sustaining varying damage to the nigrostriatal dopamine (DA) projection. DA metabolism, inferred from concentrations of dihydroxy-phenylacetic acid (DOPAC) or homovanillic acid (HVA), decreased with DA denervation of more than 20%. Dopamine release...

journal_title：Neuroscience letters

authors： Altar CA,Marien MR

更新日期：1989-01-30 00:00:00