A close look at axonal transport: Cargos slow down when crossing stationary organelles.

Abstract:

:The bidirectional transport of cargos along the thin axon is fundamental for the structure, function and survival of neurons. Defective axonal transport has been linked to the mechanism of neurodegenerative diseases. In this paper, we study the effect of the local axonal environment to cargo transport behavior in neurons. Using dual-color fluorescence imaging in microfluidic neuronal devices, we quantify the transport dynamics of cargos when crossing stationary organelles such as non-moving endosomes and stationary mitochondria in the axon. We show that the axonal cargos tend to slow down, or pause transiently within the vicinity of stationary organelles. The slow-down effect is observed in both retrograde and anterograde transport directions of three different cargos (TrkA, lysosomes and TrkB). Our results agree with the hypothesis that bulky axonal structures can pose as steric hindrance for axonal transport. However, the results do not rule out the possibility that cellular mechanisms causing stationary organelles are also responsible for the delay in moving cargos at the same locations.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Che DL,Chowdary PD,Cui B

doi

10.1016/j.neulet.2015.10.066

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

110-6

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(15)30228-7

journal_volume

610

pub_type

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