Abstract:
:We examined effects of centrally administered capsaicin on sympathetic nerve activity (SNA), blood pressure (BP) and heart rate (HR) in chloralose anesthetized cats (n = 18). Upon perfusion of the lower brain stem via the left vertebral artery, capsaicin (0.1-1.0 microM) caused dose-dependent increases in preganglionic SNA (recorded from the white ramus T3) that were associated with rises in BP and HR. These responses resembled closely those obtained during perfusions with CO2-enriched (40-80%) saline. Coadministration of capsaicin and CO2 resulted in additively increased responses. The effects of capsaicin, but not those of CO2, were significantly counteracted by the capsaicin antagonist capsazepine and ruthenium red. These results suggest that a specific central chemosensitivity activated by vanilloid receptor agonists may modulate hypercapnic and/or acidic sympathoexcitatory stimuli in vivo.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Seller H,Czachurski J,Zanzinger Jdoi
10.1016/s0304-3940(97)00280-2subject
Has Abstractpub_date
1997-05-02 00:00:00pages
195-8issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(97)00280-2journal_volume
226pub_type
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