Approaching threats elicit a freeze-like response in humans.

Abstract:

:Freezing is one of the most widely recognized defensive reactions to approaching threats in animals. Here we tested whether the same stimuli can elicit freeze-like responses in healthy humans as well. We used a modified version of the two-frame apparent motion paradigm, in which both size and location of a stimulus within a background were manipulated; by these means, participants perceived the stimuli as approaching or receding. In Experiment 1, we showed that implicitly processed approaching threats (e.g., spiders or snakes) elicited a stronger freeze-like response (operationalized as slower reaction times) with respect to receding threats; freezing was significantly related to higher levels of participants' state anxiety. In Experiment 2, approaching/threatening animals were explicitly judged as more threatening than receding ones. Finally, in two further control experiments we observed that the same manipulation of stimuli's size and location, but in absence of apparent motion, did not affect freezing (Experiment 3) or explicit threat judgements (Experiment 4). The present findings demonstrated that approaching threats are critical to elicit freezing in humans, in line with animals' behaviour.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Sagliano L,Cappuccio A,Trojano L,Conson M

doi

10.1016/j.neulet.2013.12.038

subject

Has Abstract

pub_date

2014-02-21 00:00:00

pages

35-40

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(13)01119-1

journal_volume

561

pub_type

杂志文章
  • Endothelin receptors in the detached retina of the pig.

    abstract::Endothelin-1 (ET-1) is a potent vasoconstrictor that causes hypoperfusion of the neurosensory retina. We investigated immunohistochemically the expression of the receptors for ET-1, ET(A) and ET(B), in control and locally detached retinas of the pig. Immunoreactivity for ET(A) was expressed in the innermost retinal la...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.04.056

    authors: Iandiev I,Uhlmann S,Pietsch UC,Biedermann B,Reichenbach A,Wiedemann P,Bringmann A

    更新日期:2005-08-12 00:00:00

  • Lophozozymus pictor toxin: a potent inhibitor of synaptosomal GABA uptake.

    abstract::A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(79)96171-8

    authors: Tan CH,Abkowitz SJ

    更新日期:1979-10-01 00:00:00

  • Localized brain activation by selective tasks improves specific cognitive functions in humans.

    abstract::Neuroimaging studies have identified cognitive tasks that can selectively activate specific parts of the brains. However, the subsequent effect of localized brain activation on the cognitive functioning remains unclear. We discovered that after being engaged in the novel picture encoding task to activate hippocampus f...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)00947-2

    authors: Chan AS,Cheung M,Ho Y,Jing He W

    更新日期:2000-04-07 00:00:00

  • Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: evidence for the lysosomal degradation of altered tau in human brain?

    abstract::Little is known about the metabolic process of tau and tau-derived substances. Alz-50- and tau 2-immunoreactivities in intracellular granules of neurons were observed in regions surrounding infarcted foci in the human cerebral cortex. Ultrastructurally, these granules in the fresh infarcted region exhibited primary ly...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01009-0

    authors: Ikeda K,Akiyama H,Arai T,Kondo H,Haga C,Tsuchiya K,Yamada S,Murayama S,Hori A

    更新日期:2000-04-28 00:00:00

  • Heroin-based crack induces hyperalgesia through β-arrestin 2 redistribution and phosphorylation of Erk1/2 and JNK in the periaqueductal gray area.

    abstract::Continuous use of crack induces hyperalgesia which is related to drug tolerance. Despite cumulative evidence based on the growth rate of crack abuse, no serious study has been focused on the mechanisms of crack-induced hyperalgesia. This study aimed to elucidate whether extracellular signal-regulated kinases (Erk1/2)/...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2019.01.023

    authors: Aberoumandi SM,Vousooghi N,Tabrizi BA,Karimi P

    更新日期:2019-04-17 00:00:00

  • Neuroprotective effects of carvedilol, a new antihypertensive, at the N-methyl-D-aspartate receptor.

    abstract::Carvedilol's potent antioxidant activity could explain its protective action in brain ischemia, but may not apply to glutamate-induced excitotoxicity in cultured cerebellar granule cells, since glutamate neurotoxicity was not associated with the formation of lipid peroxidative products. Rather, carvedilol diminished t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90798-c

    authors: Lysko PG,Lysko KA,Webb CL,Feuerstein G

    更新日期:1992-12-14 00:00:00

  • Renshaw cells are inactive during motor inhibition elicited by the pontine microinjection of carbachol.

    abstract::The present study was undertaken to determine whether the postsynaptic inhibition of motoneurons that occurs following the pontine microinjection of carbachol in the decerebrate cat is due to the activity of Renshaw cells. Thirty-two out of 37 Renshaw cells (86%) were spontaneously active prior to the administration o...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90498-3

    authors: Morales FR,Engelhardt JK,Pereda AE,Yamuy J,Chase MH

    更新日期:1988-04-12 00:00:00

  • Plasminogen enhances the secretion of plasminogen activator inhibitor-1 from cultured rat astrocytes.

    abstract::To investigate the physiological significance of microglia-derived plasminogen (PGn) in the central nervous system, we determined the effects of rat PGn on the secretion of plasminogen activator inhibitor (PAI) in cultured rat astrocytes by reverse zymography and Western blotting. The cultured astrocytes normally prod...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)00860-0

    authors: Liu Y,Honda S,Kohsaka S,Nakajima K

    更新日期:2000-03-24 00:00:00

  • Brain dynamics in theta and alpha frequency bands and working memory performance in humans.

    abstract::In this study non-linear and linear global electroencephalogram (EEG) changes during a visual working memory task were studied using a separate analysis of theta, lower alpha and upper alpha band filtered data. EEGs were recorded in 21 healthy subjects (62.5 year; SD 2.1; 12 females, nine males) during an eyes-closed ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01109-5

    authors: Stam CJ

    更新日期:2000-06-02 00:00:00

  • Hippocampal ether-à-go-go1 potassium channels blockade: effects in the startle reflex and prepulse inhibition.

    abstract::Recently, our group described the ether-à-go-go1(Eag1) voltage-gated potassium (K(+)) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. The increase of dopamine neurotransmission induces a red...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.11.026

    authors: Issy AC,Fonseca JR,Pardo LA,Stühmer W,Del Bel EA

    更新日期:2014-01-24 00:00:00

  • 1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes.

    abstract::Metabotropic glutamate receptors are selectively activated by 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). [3H]Glutamate binding sites in rat brain membranes were characterized in the presence of (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, and N-methyl-D-aspartate (N...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90213-q

    authors: Schoepp DD,True RA

    更新日期:1992-09-28 00:00:00

  • Seasonal variations of the beta-endorphin neuronal system in the mediobasal hypothalamus of the jerboa (Jaculus orientalis).

    abstract::The distribution of neurons expressing beta-endorphin immunoreactivity was explored in the brain of adult jerboa during two distinct periods characterizing its reproductive cycle. A large presence of cell bodies displaying beta-endorphin immunoreactivity occured within different parts of the mediobasal hypothalamus al...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.11.035

    authors: El Ouezzani S,Tramu G,Magoul R

    更新日期:2005-03-11 00:00:00

  • Chronic activation of protein kinase C by phorbol ester reduces calcium channel expression in chick sympathetic neurons.

    abstract::Chronic activation of protein kinase C (PKC) has been implicated in regulation of Ca2+ entry responsible for normal development of transmitter properties in cultured sympathetic neurons. The idea that PKC alters the expression of Ca2+ channels was tested using phorbol 12,13-dibutyrate (PDB) which activates PKC and als...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00427-8

    authors: Przywara DA,Zhong H,Kulkarni JS,Anderson GF,Wakade AR

    更新日期:1997-06-27 00:00:00

  • The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease.

    abstract::The ubiquitin carboxy-terminal hydrolase L1gene (UCH-L1) has been implicated in the aetiology of Parkinson's disease (PD). A rare Ile93Met mutation in UCH-L1 in a German PD sib-pair has been reported. Recently, a S18Y (C54A) polymorphism in exon 3 of UCH-L1 was found to be under-represented in PD patients compared to ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01510-x

    authors: Mellick GD,Silburn PA

    更新日期:2000-10-27 00:00:00

  • Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat.

    abstract::The molecular regulation of seizure-induced neuronal death may involve interactions between proteins of the Bcl-2 and 14-3-3 families. To further examine these pathways we performed subcellular fractionation on hippocampi obtained following a brief period of status epilepticus in the rat. Western blotting determined s...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2003.11.048

    authors: Schindler CK,Shinoda S,Simon RP,Henshall DC

    更新日期:2004-02-19 00:00:00

  • Is light receptor a dipole? Electrophysiological study in an arachnid.

    abstract::Retinal action potential (RAP) was recorded at different depths in the median eye of scorpion, using a glass micropipette electrode (tip diameter 2-3 mum). The amplitude of RAP was largest when the tip of the electrode touched the distal process of the receptor cell (RC). The polarity of RAP became reversed when the t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(77)90164-1

    authors: Ramakrishna T

    更新日期:1977-06-01 00:00:00

  • SOX21-AS1 modulates neuronal injury of MMP+-treated SH-SY5Y cells via targeting miR-7-5p and inhibiting IRS2.

    abstract::Parkinson's disease (PD), caused by the decreased number of dopaminergic neurons in the substantia nigra, is identified as the second most familiar age-dependent neurodegenerative disease to the public. Long non-coding RNAs (lncRNAs) have been reported to participate in the development of PD. In our research, the expr...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2020.135602

    authors: Xie Y,Zhang S,Lv Z,Long T,Luo Y,Li Z

    更新日期:2021-01-06 00:00:00

  • Acute bouts of active and passive leg cycling attenuate the amplitude of the soleus H-reflex in humans.

    abstract::This study compared the immediate and prolonged effects of acute bouts of active and passive leg cycling on the soleus H-reflex among 12 young healthy men. The soleus H-reflex was measured immediately before and then 10 and 30 min after 20 min of active, unloaded leg cycling, passively induced leg cycling, and quiet r...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00652-9

    authors: Motl RW,Knowles BD,Dishman RK

    更新日期:2003-08-21 00:00:00

  • The LRRK2 G2019S mutation in a series of Argentinean patients with Parkinson's disease: clinical and demographic characteristics.

    abstract:OBJECTIVES:To determine clinical characteristics and frequency of leucine-rich repeat kinase 2 gene (LRRK2) mutations in a cohort of patients with Parkinson's disease (PD) from Argentina. BACKGROUND:Variation in the LRRK2 gene represents the most common genetic determinant of PD, only few data are available from Latin...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.01.011

    authors: Gatto EM,Parisi V,Converso DP,Poderoso JJ,Carreras MC,Martí-Massó JF,Paisán-Ruiz C

    更新日期:2013-03-14 00:00:00

  • The change of circulating insulin like growth factor binding protein 7 levels may correlate with postoperative cognitive dysfunction.

    abstract::Insulin-like growth factor binding protein (IGFBP) 7 may be a critical regulator of memory consolidation. This study was performed to assess the relationship between circulating IGFBP7 levels and postoperative cognition dysfunction (POCD) in patients scheduled for elective head and neck carcinoma surgery under general...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.12.046

    authors: Jiang J,Chen Z,Liang B,Yan J,Zhang Y,Xu H,Huang Y,Jiang H

    更新日期:2015-02-19 00:00:00

  • Striatal cholinergic activity during morphine-induced catalepsy in the rat: development of tolerance.

    abstract::Morphine hydrochloride (10 mg/kg,i.p.) induced marked catalepsy in rats, which was associated with significantly enhanced striatal acetylcholine levels and reduced cholinesterase activity. Rapid tolerance to morphine-induced catalepsy was noted after twice daily administrations, the tolerance being discernible after t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(79)95355-2

    authors: Bose R,Kumar A,Bhattacharya SK

    更新日期:1979-09-01 00:00:00

  • Long-term depression is not modulated by ATP receptors in the rat CA1 hippocampal region.

    abstract::ATP is an important extracellular messenger in the CNS. In the hippocampus, a brain structure relevant for learning and memory processes, it acts both as a modulator and as a mediator of synaptic transmission, with implications for synaptic plasticity phenomena. Recent evidence suggests that ATP modulates activity-dep...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.04.051

    authors: da Silva BM,de Mendonça A,Ribeiro JA

    更新日期:2005-08-05 00:00:00

  • Branching enhancement by basic fibroblast growth factor in cut neurite of hippocampal neurons.

    abstract::Basic fibroblast growth factor (bFGF) has strong neurotrophic effects both in vivo and in vitro on various brain neurons. bFGF enhanced the branching of laser beam-damaged axons of primary cultured hippocampal neurons with a suppression of the neurite's re-elongation. Conditioned medium prepared from astrocytes, on th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90069-w

    authors: Miyagawa T,Saito H,Nishiyama N

    更新日期:1993-04-16 00:00:00

  • Evoked transmitter release at the frog neuromuscular junction in the presence of very low extracellular Ca2+.

    abstract::We have examined the effect of ouabain, a Na,K-ATPase inhibitor known to secondarily increase intracellular Ca2+ levels, on evoked (phasic) transmitter release at the frog neuromuscular junction. As had been reported previously, we observed an increase in both spontaneous and evoked release with prolonged exposure to ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90104-x

    authors: Mosier DR,Zengel JE

    更新日期:1994-06-06 00:00:00

  • Behavioral effects of Splenda, Equal and sucrose: Clues from planarians on sweeteners.

    abstract::Sweetened diets share commonalities with drugs of abuse, but studies comparing behavioral effects of different sweeteners are lacking. Common table sugar produces rewarding and withdrawal effects in planarians. We postulated that Splenda and Equal would produce similar responses and used a tetrad of behavioral assays ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.11.017

    authors: Ouyang K,Nayak S,Lee Y,Kim E,Wu M,Tallarida CS,Rawls SM

    更新日期:2017-01-01 00:00:00

  • Localization and synaptic effects of inhibitory vestibulocollic neurons activated by the posterior semicircular canal nerve in the cat.

    abstract::Cellular locations, axonal projections, and synaptic effects of inhibitory vestibulocollic (VC) neurons activated by the ampullary nerve of the posterior semicircular canal (PCN) were studied in anesthetized cats. The inhibitory VC neurons were identified by their monosynaptic responses to PCN stimulation and by their...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90824-s

    authors: Isu N,Sakuma A,Hiranuma K,Ichikawa T,Uchino Y

    更新日期:1990-11-13 00:00:00

  • Soft-food diet induces oxidative stress in the rat brain.

    abstract::Decreased dopamine (DA) release in the hippocampus may be caused by dysfunctional mastication, although the mechanisms involved remain unclear. The present study examined the effects of soft- and hard-food diets on oxidative stress in the brain, and the relationship between these effects and hippocampal DA levels. The...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.12.015

    authors: Yoshino F,Yoshida A,Hori N,Ono Y,Kimoto K,Onozuka M,Lee MC

    更新日期:2012-02-02 00:00:00

  • Intracellular dyes mask immunoreactivity of hippocampal interneurons.

    abstract::The results of several studies have suggested that local circuit neurons, or interneurons, of area CA1 of hippocampus use gamma-aminobutyric acid (GABA) as their neurotransmitter. However, when these cells were labelled by intracellular dye injection, and examined immunocytochemically with antisera raised against GABA...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90237-1

    authors: Scharfman HE,Kunkel DD,Schwartzkroin PA

    更新日期:1989-01-02 00:00:00

  • The recognition potential reflects an intermediate level of visual representation.

    abstract::A well-known event-related potential (ERP) component-the recognition potential (RP) is a response to recognizable stimuli, peaking at around 200-250 ms. The aim of the present study is to put to the test the contrasting perceptual and semantic accounts of the RP, with manipulation of word meaning and presentation form...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.02.047

    authors: Zhang Y,Liu Q,Zhang Q

    更新日期:2009-04-17 00:00:00

  • Staurosporine and H7 attenuate ethanol-induced elevation in [Ca2+]i in cultured canine cerebral vascular smooth muscle cells.

    abstract::Chronic exposure of cultured canine cerebral vascular smooth muscle cells to ethanol (10-400 mM) for 1-5 days resulted in significant concentration-dependent elevation in resting intracellular free calcium ([Ca2+]i) levels. Preincubation of these cultured vascular cells with inhibitors of protein kinase C (PKC), staur...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)00016-0

    authors: Zheng T,Li W,Zhang A,Altura BT,Altura BM

    更新日期:1998-01-30 00:00:00