当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms.

Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms.

Abstract：

:Insulin-like growth factor-1 (IGF1) and its active peptide (1-3)IGF1 modulate brain growth and plasticity and are candidate molecules for treatment of brain disorders. IGF1 N-terminal portion is naturally cleaved to generate the tri-peptide (1-3)IGF1 (glycine-praline-glutamate). IGF1 and (1-3)IGF have been proposed as treatment for neuropathologies, yet their effect on nerve cells has not been directly compared. In this study we examine the effects of IGF1 and (1-3)IGF1 in primary cortical cultures and measure the expression levels of markers for intracellular pathways and synaptic function. We find that both treatments activate the IGF1 receptor and enhance the expression of synaptic markers, however, they activate different intracellular pathways. Furthermore, (1-3)IGF1 administration increases the expression of endogenous IGF1, suggesting a direct interaction between the two molecules. The results show that the two molecules increase the expression of synaptic proteins through activating different cellular mechanisms.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Corvin AP,Molinos I,Little G,Donohoe G,Gill M,Morris DW,Tropea D

doi

10.1016/j.neulet.2012.05.029

subject

Has Abstract

pub_date

2012-06-27 00:00:00

pages

51-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(12)00675-1

journal_volume

520

pub_type

杂志文章

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