Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection, and with sparse CNS infiltration.

abstract：:MicroRNAs, such as miR-34, have been reported to influence age-related diseases. In this study, we explored the role of the miR-34a/Bcl-2 signaling pathway in age-related hearing loss (AHL). Using an AHL mouse model (C57BL/6), we found that the expression of miR-34a in the cochlea increased with age, whereas expressio...

journal_title：Neuroscience letters

authors： Huang Q,Zheng Y,Ou Y,Xiong H,Yang H,Zhang Z,Chen S,Ye Y

更新日期：2017-11-20 00:00:00

abstract：:To determine whether a trans-synaptic mechanism triggered the effects of reserpine on adrenomedullary mRNAs encoding the norepinephrine transporter and tyrosine hydroxylase, we administered 10 mg/kg reserpine to rats after unilateral splanchnicotomy, and examined their adrenal medullas using quantitative in situ hybri...

journal_title：Neuroscience letters

authors： Cubells JF,Baker H,Volpe BT,Smith GP,Das SS,Joh TH

更新日期：1995-07-07 00:00:00

abstract：:Four substance P (SP) antagonists were tested on anaesthetized rats, by injecting 8 microgram amounts into the spinal cord (T8-T9), and by observing their effects on the hypothalamo-neurohypophysial responses to a presumably painful stimulus, the superfusion of the hepatic portal vein with 1 microM bradykinin. Only tw...

journal_title：Neuroscience letters

authors： Stoppini L,Baertschi AJ,Mathison R,Barja F

更新日期：1983-06-30 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA)-evoked release of [3H]acetylcholine (ACh) from slices of rat brain medial septum/vertical limb of the diagonal band (ms/vdB) was examined. NMDA increased the release of tritium in a concentration-dependent manner and the specific non-competitive NMDA antagonist, MK-801, and the competitive ...

journal_title：Neuroscience letters

authors： Nishimura LM,Boegman RJ

更新日期：1990-07-31 00:00:00

abstract：:We investigated whether the perceived roughness of the end of a tool is influenced by the texture of the handle used to hold it. Participants rated the roughness of the ends (caps) of a series of tools by rubbing them along their forearm, and indicated the perceived roughness of the tool's cap by means of an anchored ...

journal_title：Neuroscience letters

authors： Zampini M,Mawhinney S,Spence C

更新日期：2006-06-12 00:00:00

abstract：:The effects of methysergide (1 mg, p.o.), clonidine (50 micrograms, i.m.) and methysergide plus clonidine on growth hormone (GH) and prolactin (PRL) secretion in 8 normal male volunteers have been studied. Both methysergide and clonidine were found to enhance GH and to lower PRL plasma levels. The effects of methyserg...

journal_title：Neuroscience letters

authors： Agnati LF,Benfenati F,Capelli M,Cocchi V,D'Errico A,Bernardi P

更新日期：1981-02-06 00:00:00

abstract：:The study examined whether the generation of the forward propulsive force (PF) during gait initiation resulted mainly from the electromyogram activity of stance ankle plantar flexor muscles (APF) which 'push' on the ground as is generally claimed in the literature. Six unilateral above-knee amputees performed a specif...

journal_title：Neuroscience letters

authors： Michel V,Do MC

更新日期：2002-06-07 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is a developmental disorder characterized by inattentiveness, motor hyperactivity and impulsivity. According to neuroimaging data, the neural substrate underlying ADHD seems to involve fronto-striatal circuits and the cerebellum. However, there are important discrepancie...

journal_title：Neuroscience letters

authors： Carmona S,Vilarroya O,Bielsa A,Trèmols V,Soliva JC,Rovira M,Tomàs J,Raheb C,Gispert JD,Batlle S,Bulbena A

更新日期：2005-12-02 00:00:00

abstract：:The objective of the present study was to characterize the trkB receptor immunoreactive (-ir) cells in the intermediolateral cell column (IML) of the upper thoracic spinal cord. Small trkB-ir cells (area=56.1+/-4.4 microm(2)) observed in the IML showed characteristics of oligodendrocytes and were frequently observed i...

journal_title：Neuroscience letters

authors： McCartney AM,Abejuela VL,Isaacson LG

更新日期：2008-08-01 00:00:00

abstract：:Little is known about the metabolic process of tau and tau-derived substances. Alz-50- and tau 2-immunoreactivities in intracellular granules of neurons were observed in regions surrounding infarcted foci in the human cerebral cortex. Ultrastructurally, these granules in the fresh infarcted region exhibited primary ly...

journal_title：Neuroscience letters

authors： Ikeda K,Akiyama H,Arai T,Kondo H,Haga C,Tsuchiya K,Yamada S,Murayama S,Hori A

更新日期：2000-04-28 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) was used to investigate cortical activity related to differential control of the human phonatory system during a sentence production task. Our focus in this report was on activation of the temporo-parietal (TP) junctional region, suggested by recent models in speech product...

journal_title：Neuroscience letters

authors： Andreatta RD,Stemple JC,Joshi A,Jiang Y

更新日期：2010-10-22 00:00:00

abstract：:The present study was undertaken to determine whether the postsynaptic inhibition of motoneurons that occurs following the pontine microinjection of carbachol in the decerebrate cat is due to the activity of Renshaw cells. Thirty-two out of 37 Renshaw cells (86%) were spontaneously active prior to the administration o...

journal_title：Neuroscience letters

authors： Morales FR,Engelhardt JK,Pereda AE,Yamuy J,Chase MH

更新日期：1988-04-12 00:00:00

abstract：:We evaluated long-term dynorphin A-immunoreactivity in the rat area postrema (AP) after the administration of cisplatin. First, rats were given 1, 5 and 10mg/kg body weight cisplatin (i.p.) and their behavior was monitored for 72h. We observed a delayed increase in pica 24-72h after injection, compared to the 24h befo...

journal_title：Neuroscience letters

authors： Tsukamoto G,Ichikawa H,Kobashi M,Yamada Y,Kikuchi T,Mese H,Sasaki A

更新日期：2007-09-07 00:00:00

abstract：:Injection of the triceps brachii muscle of the rat with horseradish peroxidase (HRP) led to labeling of motoneurons in the dorsolateral and ventral aspects of the ventral grey horn of the brachial spinal cord. Ventral, labeled neurons were absent, however, in rats in which the motor branches of the radial nerve to tri...

journal_title：Neuroscience letters

authors： Haase P,Hrycyshyn AW

更新日期：1985-10-10 00:00:00

abstract：:The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats. Central administration of irisin...

journal_title：Neuroscience letters

authors： Zhang W,Chang L,Zhang C,Zhang R,Li Z,Chai B,Li J,Chen E,Mulholland M

更新日期：2015-05-19 00:00:00

abstract：:The dentate gyrus of the hippocampus is one of few regions in the adult mammalian brain characterized by ongoing neurogenesis. It has been demonstrated that Noggin antagonizes bone morphogenetic protein-4 (BMP4) to create a niche for subventricular zone neurogenesis. We previously demonstrated that Noggin and BMP4 sho...

journal_title：Neuroscience letters

authors： Fan XT,Xu HW,Cai WQ,Yang H,Liu S

更新日期：2004-08-05 00:00:00

abstract：:Plasma studies depict collisionless, collective movements of charged particles. In touch with these concepts, originally developed by the far-flung branch of high energy physics, here we evaluate the role of collective behaviors and long-range functional couplingsof charged particlesin brain dynamics. We build a novel...

journal_title：Neuroscience letters

authors： Tozzi A,Peters JF,Déli E

更新日期：2018-01-01 00:00:00

abstract：:It is well known that genetic variants play a critical role in the pathogenesis of Alzheimer's disease (AD). In 2009, a genome-wide association study (GWAS) demonstrated that a single nucleotide polymorphism (SNP), rs6656401, in complement receptor 1 (CR1) is significantly associated with late-onset Alzheimer's diseas...

journal_title：Neuroscience letters

authors： Jin C,Li W,Yuan J,Xu W,Cheng Z

更新日期：2012-10-03 00:00:00

abstract：:The content of the neurosteroids, dehydroepiandrosterone (DHEA) in the brain decreases with aging. Also the oxidative energy metabolism is known to decrease with aging. Hence we examined the effects of treatment with DHEA (0.2 or 1.0 mg/kg body weight for 7 days) on oxidative energy metabolism in brain mitochondria fr...

journal_title：Neuroscience letters

authors： Patel MA,Katyare SS

更新日期：2006-07-10 00:00:00

abstract：OBJECTIVES:Suicide attempt in schizophrenia is an important clinical issue. We performed a genome-wide association study to identify genetic markers, which increase the risk for suicide attempt in schizophrenia. METHODS:Suicide attempt lifetime was assessed in 121 schizophrenia patients and defined by the means of the...

journal_title：Neuroscience letters

authors： Bani-Fatemi A,Graff A,Zai C,Strauss J,De Luca V

更新日期：2016-05-27 00:00:00

abstract：:Pitch and duration -- either as written symbols or in auditory form -- are the basic structural properties in tones that form a melodic sequence. From the cognitive perspective, it is still a matter of debate whether, and at which processing stage, these two factors are processed independently or interdependently. The...

journal_title：Neuroscience letters

authors： Neuhaus C,Knösche TR

更新日期：2008-08-15 00:00:00

abstract：:Neuraxial analgesia is often provided using a mixture of local anesthetics and opioids. This combination of agents provides better pain relief and is generally associated with fewer side effects than when either drug is given alone. Local anesthetics have been shown to alter signaling of other G protein-coupled recept...

journal_title：Neuroscience letters

authors： Komai H,McDowell TS

更新日期：2007-05-18 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) has strong neurotrophic effects both in vivo and in vitro on various brain neurons. bFGF enhanced the branching of laser beam-damaged axons of primary cultured hippocampal neurons with a suppression of the neurite's re-elongation. Conditioned medium prepared from astrocytes, on th...

journal_title：Neuroscience letters

authors： Miyagawa T,Saito H,Nishiyama N

更新日期：1993-04-16 00:00:00

abstract：:Neuronal cell cycle activation has been implicated in neurodegenerative diseases such as Alzheimer's disease, while the initiating mechanism of cell cycle activation remains to be determined. Interestingly, our previous studies have shown that cell cycle activation by c-Myc (Myc) leads to neuronal cell death which sug...

journal_title：Neuroscience letters

authors： Lee HP,Kudo W,Zhu X,Smith MA,Lee HG

更新日期：2011-11-14 00:00:00

abstract：:The homozygous Brattleboro rat (di/di) synthesizes a vasopressin (VP) precursor with an aberrant C-terminus, which causes a hypothalamic form of diabetes insipidus. The neuroendocrine polypeptide 7B2 is present in VP and oxytocin (OT) neurons of the supraoptic and paraventricular nucleus of the hypothalamus in wild ty...

journal_title：Neuroscience letters

authors： Gabreëls BA,Verwer RW,Sonnemans MA,Sluiter AA,Ang CW,van Leeuwen FW

更新日期：1997-12-12 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors which belong to the nuclear receptor family. We examined whether PPARalpha agonists and resveratrol, a polyphenol contained in grapes, protect the brain against ischemia. To investigate whether resveratrol activates PPARs, w...

journal_title：Neuroscience letters

authors： Inoue H,Jiang XF,Katayama T,Osada S,Umesono K,Namura S

更新日期：2003-12-11 00:00:00

abstract：:Using frozen-thawed and extensively washed rat cortical membranes, the effects of 3-((+/-)2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) on [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) binding stimulated by either 1 microM L-glutamate or 300 microM Mg2+ were examined. CPP much more potently inhibit...

journal_title：Neuroscience letters

authors： Hatta K,Yamamato T,Hori T,Okuwa M,Moroji T

更新日期：1991-04-01 00:00:00

abstract：:Opioid kappa-agonists had much more potent inhibitory effects on the high K+-evoked Met-enkephalin release from rat brain slices than did the mu- or delta-agonists. The opioid kappa- antagonist, MR2266 enhanced the evoked release of Met-enkephalin to a greater extent than did mu- or delta-antagonists in vitro and had ...

journal_title：Neuroscience letters

authors： Ueda H,Fukushima N,Ge M,Takagi H,Satoh M

更新日期：1987-10-29 00:00:00

abstract：:G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migratio...

journal_title：Neuroscience letters

authors： Schmalzigaug R,Rodriguiz RM,Phillips LE,Davidson CE,Wetsel WC,Premont RT

更新日期：2009-02-20 00:00:00

abstract：:Mood stabilizers are a category of medications used in the management of mood disorders. The mood stabilizing properties of lithium were first reported in 1949 by John Cade, and since then it has been considered the first line treatment for bipolar disorder. Despite presenting more differences than similarities, mood ...

journal_title：Neuroscience letters

authors： Pisanu C,Papadima EM,Del Zompo M,Squassina A

更新日期：2018-03-16 00:00:00