Anxiety-like behaviors in mice lacking GIT2.

Abstract:

:G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migration. To evaluate possible neurobehavioral functions of GIT2 in vivo, we evaluated GIT2-knockout (KO) mice for abnormalities in emotionality and mood. Male and female GIT2-KO mice presented with anxiety-like behaviors in the zero-maze and light-dark emergence tests. Immobility times in tail suspension were reduced in GIT2-KO males, but were normal in GIT2-KO females. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Schmalzigaug R,Rodriguiz RM,Phillips LE,Davidson CE,Wetsel WC,Premont RT

doi

10.1016/j.neulet.2008.12.034

subject

Has Abstract

pub_date

2009-02-20 00:00:00

pages

156-61

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(08)01722-9

journal_volume

451

pub_type

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