Antisense Noggin oligodeoxynucleotide administration decreases cell proliferation in the dentate gyrus of adult rats.

Abstract:

:The dentate gyrus of the hippocampus is one of few regions in the adult mammalian brain characterized by ongoing neurogenesis. It has been demonstrated that Noggin antagonizes bone morphogenetic protein-4 (BMP4) to create a niche for subventricular zone neurogenesis. We previously demonstrated that Noggin and BMP4 showed strong expression in the proliferative subgranular layer of the dentate gyrus in adult rats. To examine the action of Noggin on cell proliferation in the dentate gyrus of adult rats, we administered antisense oligodeoxynucleotide (ASODN) to Noggin by continuous infusion into the lateral ventricle of rats. Antisense-infused rats displayed significant reduction in number of bromodeoxyuridine (BrdU) labeled cells in the dentate gyrus. This indicated that endogenous Noggin activity is important for naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Fan XT,Xu HW,Cai WQ,Yang H,Liu S

doi

10.1016/j.neulet.2004.05.043

keywords:

subject

Has Abstract

pub_date

2004-08-05 00:00:00

pages

107-11

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304394004006196

journal_volume

366

pub_type

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