Abstract：
:In this study, we investigated two newly reported polymorphisms in association with late onset Alzheimer's disease (AD) in Chinese. They were a -491 A/T polymorphism in the Apolipoprotein E (APOE) promoter region and a five base pair deletion at exon 18 of alpha2-Macroglobin (A2M). There were 196 AD and 180 normal controls (N), which were age- and sex-matched. APOE epsilon4 alleles were significantly increased in AD vs. N (chi2 = 33.3, P < 0.000001). However, neither the -491 A/T (chi2 = 1.13, P = 0.29) nor A2M (chi2 = 0.18, P = 0.67) polymorphism was associated with AD risk, suggesting that these polymorphisms do not represent risk factors for AD in the Chinese population.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chen L,Baum L,Ng HK,Chan LY,Sastre I,Artíga MJ,Valdivieso F,Bullido MJ,Chiu HF,Pang CPdoi
10.1016/s0304-3940(99)00421-8keywords:
subject
Has Abstractpub_date
1999-07-16 00:00:00pages
173-7issue
3eissn
0304-3940issn
1872-7972pii
S0304394099004218journal_volume
269pub_type
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