Abstract:
:Rat neocortical slices maintained in Mg2(+)-free Krebs medium developed spontaneous paroxysmal discharges which were attenuated or suppressed by the gamma-aminobutyric acid-B (GABAB) receptor agonist baclofen, occasionally accompanied by a slight hyperpolarisation, and antagonised by the specific GABAB-receptor antagonist, 2-OH-saclofen. Over the same dose range, the GABA-analogue 3-amino-propylphosphinic acid (3-APA) caused a marked, prompt hyperpolarisation with little or no effect on the frequency of the discharges, although their amplitude was attenuated. In the presence of 2-OH-saclofen, 3-APA still induced a hyperpolarisation but the amplitude of the discharges was no longer affected. This marked difference in action between baclofen and 3-APA in the rat neocortical slices suggests there may be a heterogeneity of GABAB-receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ong J,Kerr DI,Johnston GA,Hall RGdoi
10.1016/0304-3940(90)90557-psubject
Has Abstractpub_date
1990-02-05 00:00:00pages
169-73issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90557-Pjournal_volume
109pub_type
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