当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein.

Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein.

Abstract：

:Parkinson disease (PD) features profound striatal dopamine depletion and Lewy bodies containing abundant precipitated alpha-synuclein. Mechanisms linking alpha-synucleinopathy with the death of dopamine neurons remain incompletely understood. One such link may be 3,4-dihydroxyphenylacetaldehyde (DOPAL). All of the intra-neuronal metabolism of dopamine passes through DOPAL, which is toxic. DOPAL also potently oligomerizes alpha-synuclein and alpha-synuclein oligomers are thought to be pathogenic in PD. Another implicated factor in PD pathogenesis is metal ions, and alpha-synuclein contains binding sites for these ions. In this study we tested whether divalent metal ions augment DOPAL-induced oligomerization of alpha-synuclein in cell-free system and in PC12 cells conditionally over-expressing alpha-synuclein. Incubation with divalent metal ions augmented DOPAL-induced oligomerization of alpha-synuclein (Cu(2+)>Fe(2+)>Mn(2+)), whereas monovalent Cu(1+) and trivalent Fe(3+) were without effect. Other dopamine metabolites, dopamine itself, and metal ions alone or in combination with dopamine, also had no effect. Antioxidant treatment with ascorbic acid and divalent cation chelation with EDTA attenuated the augmentation by Cu(2+) of DOPAL-induced alpha-synuclein oligomerization. Incubation of PC12 cells with L-DOPA markedly increased intracellular DOPAL content and promoted alpha-synuclein dimerization. Co-incubation with Cu(2+) amplified (p=0.01), while monoamine oxidase inhibition prevented, L-DOPA-related dimerization of alpha-synuclein (p=0.01). We conclude that divalent metal ions augment DOPAL-induced oligomerization of alpha-synuclein. Drugs that interfere with this interaction might constitute a novel approach for future treatment or prevention approaches.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Jinsmaa Y,Sullivan P,Gross D,Cooney A,Sharabi Y,Goldstein DS

doi

10.1016/j.neulet.2014.03.016

subject

Has Abstract

pub_date

2014-05-21 00:00:00

pages

27-32

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(14)00215-8

journal_volume

569

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Brief stress impairs recognition memory through amygdalar activation in animals with medial prefrontal cortex lesions.

    abstract：:The medial prefrontal cortex (mPFC) is thought to exert inhibitory control over stress-induced activation of the amygdala and neurocognitive effects. As evidence to support this, we examined how exposure to either a brief or prolonged stress affected on amygdalar c-Fos levels and recognition memory of animals with mPF...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2020.135245

    authors： Park JC,Jeon YJ,Kim JJ,Cho J,Choi DH,Han JS

    更新日期：2020-09-14 00:00:00

  • Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus.

    abstract：:Tetanic mossy fiber stimulation transiently reduced recurrent inhibition in the rat dentate gyrus. The post-tetanic depression of inhibition was maximal 200 ms after the tetanus and typically lasted for about 2 s. Phaclofen, a selective gamma-aminobutyric acid-B (GABAB) receptor antagonist, significantly increased the...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90800-o

    authors： Mott DD,Bragdon AC,Lewis DV

    更新日期：1990-03-02 00:00:00

  • Vasoactive intestinal peptide (VIP) induces a K+ current in the Xenopus oocyte membrane.

    abstract：:Evidence, based on voltage-clamp and current-clamp recording, is presented for endogenous receptors for vasoactive intestinal polypeptide (VIP) on the cell membrane of the Xenopus oocyte. At normal resting potential a hyperpolarisation is produced by VIP, associated with an increase in K+ conductance. The response is ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(87)90221-7

    authors： Reale V,Ashford ML,Barnard EA

    更新日期：1987-12-16 00:00:00

  • Longterm stability and developmental changes in spontaneous network burst firing patterns in dissociated rat cerebral cortex cell cultures on multielectrode arrays.

    abstract：:Spontaneous action potentials were recorded longitudinally for 4-7 weeks from dissociated rat occipital cortex cells cultured on planar multi-electrode plates, during their development from isolated neurons into synaptically connected neuronal networks. Activity typically consisted of generalized bursts lasting up to ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.12.062

    authors： Van Pelt J,Corner MA,Wolters PS,Rutten WL,Ramakers GJ

    更新日期：2004-05-06 00:00:00

  • Learned defense response to hypoxia in newborn mice.

    abstract：:In newborns, hypoxia elicits defensive behaviors including awakening from sleep, body movements and crying. An inability to produce this defense response is a risk factor for sudden infant death syndrome and other respiratory control disorders. In this study, we examined the possibility that the defense response to hy...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2007.05.012

    authors： Bollen B,Bouslama M,Matrot B,D'Hooge R,Van den Bergh O,Gallego J

    更新日期：2007-06-15 00:00:00

  • Intolerance of uncertainty correlates with insula activation during affective ambiguity.

    abstract：:Intolerance of uncertainty (IU), or the increased affective response to situations with uncertain outcomes, is an important component process of anxiety disorders. Increased IU is observed in panic disorder (PD), obsessive compulsive disorder (OCD) and generalized anxiety disorder (GAD), and is thought to relate to dy...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2007.10.030

    authors： Simmons A,Matthews SC,Paulus MP,Stein MB

    更新日期：2008-01-10 00:00:00

  • Proteasome regulates transcription-favoring histone methylation, acetylation and ubiquitination in long-term synaptic plasticity.

    abstract：:Histone modifications, such as lysine methylation, acetylation and ubiquitination, are epigenetic tags that shape the chromatin landscape and regulate transcription required for synaptic plasticity and memory. Here, we show that transcription-promoting histone H3 trimethylated at lysine 4 (H3K4me3), histone H3 acetyla...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.02.029

    authors： Bach SV,Tacon PR,Morgan JW,Hegde AN

    更新日期：2015-03-30 00:00:00

  • The amygdala in schizophrenia: a trimodal magnetic resonance imaging study.

    abstract：:In schizophrenic psychoses, structural and functional alterations of the amygdala have been demonstrated by several neuroimaging studies. However, postmortem examinations on the brains of schizophrenics did not confirm the volume changes reported by volumetric magnetic resonance imaging (MRI) studies. In order to addr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.11.004

    authors： Kalus P,Slotboom J,Gallinat J,Wiest R,Ozdoba C,Federspiel A,Strik WK,Buri C,Schroth G,Kiefer C

    更新日期：2005-03-03 00:00:00

  • Glutathione redox status in mitochondria and cytoplasm differentially and sequentially activates apoptosis cascade in dopamine-melanin-treated SH-SY5Y cells.

    abstract：:Neuromelanin (NM)-containing dopaminergic neurons in the substantia nigra are selectively vulnerable in Parkinson's disease (PD), suggesting the involvement of NM in the pathogenesis. NM is composed of protein, lipid, trace metals and melanin component, a mixture of eumelanin produced from dopamine (DA)-quinone and ph...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.08.082

    authors： Naoi M,Yi H,Maruyama W,Inaba K,Shamoto-Nagai M,Akao Y,Gerlach M,Riederer P

    更新日期：2009-11-13 00:00:00

  • Excitatoty effects of TRH on medullary reticular neurones.

    abstract：:Thyrotropin releasing hormone (TRH) was applied iontophoretically to single neruones in the rat bulbar reticular formation. TRH excited 41 to 56 cells tested; none were inhibited. Excitation developed slowly and was prolonged, and desensitization often occurred. TRH effects were not correlated with effects of acetylch...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(79)91525-8

    authors： Briggs I

    更新日期：1979-11-01 00:00:00

  • Glucocerebrosidase regulators SCARB2 and TFEB are up-regulated in Lewy body disease brain.

    abstract：:Mutations in the glucocerebrosidase (GCase) gene (GBA) and GCase deficiency are major risk factors for Lewy body diseases. Decreased GCase activity enhances alpha-synuclein aggregation and disease development. Lysosomal integral membrane protein type 2, encoded by SCARB2, binds GCase targeting it to lysosomes and tran...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2019.05.034

    authors： Pérez-Roca L,Prada-Dacasa P,Segú-Vergés C,Gámez-Valero A,Serrano-Muñoz MA,Santos C,Beyer K

    更新日期：2019-07-27 00:00:00

  • Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease.

    abstract：:The association between insulin degrading enzyme (IDE) gene polymorphisms and Alzheimer's disease (AD) risk has been widely reported, but results were somewhat controversial. To assess the association between IDE polymorphisms and AD risk, a meta-analysis was performed. We systematically reviewed relevant studies retr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.neulet.2013.01.051

    authors： Zhang Y,Wang B,Wan H,Zhou Q,Li T

    更新日期：2013-04-29 00:00:00

  • Blocking of the axon spikes by pentylenetetrazol in an identified neuron of the snail Helix lucorum, with consequent induction of epileptic activity in the cell body of the same neuron.

    abstract：:In an isolated preparation which consists of the buccal ganglia and the salivary nerve of Helix lucorum, neuron B2 can be identified by simultaneously recording the soma spike intracellularly and the axon spike extracellularly from the peripheral salivary nerve. The convulsant drug pentylenetetrazol (PTZ) eliminates t...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(99)00382-1

    authors： Maratou E,Theophilidis G

    更新日期：1999-06-18 00:00:00

  • Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat.

    abstract：:Several novel melatonin receptor agonists, in addition to various formulations of melatonin itself, are either available or in development for the treatment of insomnia. Melatonin is thought to exert its effects principally through two high affinity, G-protein coupled receptors, MT1 and MT2, though it is not known whi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.04.005

    authors： Fisher SP,Sugden D

    更新日期：2009-06-26 00:00:00

  • Inhibition of ATP synthesis by 1-methyl-4-phenylpyridinium ion (MPP+) in isolated mitochondria from mouse brains.

    abstract：:Effect of 1-methyl-4-phenylpyridinium ion (MPP+) on adenosine triphosphate (ATP) synthesis was studied using isolated mitochondrial preparations from mouse brains. Oxidation of glutamate + malate in the mitochondria estimated by polarography was significantly inhibited by MPP+, and synthesis of ATP was inhibited to ap...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(87)90366-1

    authors： Mizuno Y,Suzuki K,Sone N,Saitoh T

    更新日期：1987-10-16 00:00:00

  • Single unit recordings in the nuclei raphe dorsalis and magnus during the sleep-waking cycle of semi-chronic prepared cats.

    abstract：:Single unit recordings were performed in the nuclei raphe dorsalis (RD) and raphe magnus (RM) of semi-chronic prepared cats during spontaneous or cryogenically induced sleep. Of the RD neurons 75% showed a discharge pattern which decreased during slow wave sleep and paradoxical sleep (PS); such a decrease in spiking w...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(81)90236-6

    authors： Cespuglio R,Faradji H,Gomez ME,Jouvet M

    更新日期：1981-07-02 00:00:00

  • Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients.

    abstract：:FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure of structures relevant to normal language processing. To investigat...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.02.024

    authors： Španiel F,Horáček J,Tintěra J,Ibrahim I,Novák T,Čermák J,Klírová M,Höschl C

    更新日期：2011-04-15 00:00:00

  • The extracellular calcium-sensing receptor increases the number of calcium steps and action currents in pituitary melanotrope cells.

    abstract：:Secretion of alpha-melanophore-stimulating hormone (alpha-MSH) from the neuroendocrine melanotrope cells in the intermediate lobe of the pituitary gland of the clawed frog Xenopus laevis is regulated by various inhibitory, stimulatory and autocrine factors. The neuropeptide sauvagine stimulates alpha-MSH secretion by ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.11.084

    authors： van den Hurk MJ,Jenks BG,Roubos EW,Scheenen WJ

    更新日期：2005-03-29 00:00:00

  • O-phosphohomoserine, a naturally occurring analogue of phosphonate amino acid antagonists, is an N-methyl-D-aspartate (NMDA) antagonist in rat hippocampus.

    abstract：:O-Phosphohomoserine, an analogue of the excitatory amino acid antagonist 2-amino-phosphonovalerate, has been synthesized and tested for activity as an excitatory amino acid antagonist. The tests were carried out on 500 micron thick slices of rat hippocampus superfused in vitro at 30 degrees C. Antidromic and orthodrom...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90151-5

    authors： Connick JH,Heywood GC,Smith DA,Stone TW

    更新日期：1986-07-24 00:00:00

  • Neuromelanic pigment in substantia nigra neurons of rats and dogs.

    abstract：:The presence of neuromelanic pigment in neurons of the rat substantia nigra (SN) is a matter of controversy. The presence of neuromelanin in the SN of 15--24-month-old rats was investigated by electron microscopy (EM) and the findings compared to the morphology and distribution of neuromelanin in SN of dogs. In the ra...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90614-2

    authors： DeMattei M,Levi AC,Fariello RG

    更新日期：1986-12-03 00:00:00

  • Membrane toxicity of the protein kinase C inhibitor calphostin A by a free-radical mechanism.

    abstract：:The effects of calphostin A on cytoplasmic calcium levels, receptor-mediated calcium release, and membrane input resistance were measured in neuroblastoma cells. Calphostin A is a lipophilic, light-sensitive perylenequinone that generates singlet oxygen when illuminated. It inhibits the activity of protein kinase C (I...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(93)90634-w

    authors： Wang SS,Mathes C,Thompson SH

    更新日期：1993-07-09 00:00:00

  • Chronic nicotine and smoking exposure decreases GABA(B1) receptor expression in the rat hippocampus.

    abstract：:Nicotine and smoking have long been proved to play an important role in cognition and memory in the hippocampus. This effect is closely related to the gamma-aminobutyric acid (GABA)ergic system. Previous research has focused on functional and pharmacological aspects of nicotine's modulation activity. In this study, th...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)01065-0

    authors： Li SP,Park MS,Bahk JY,Kim MO

    更新日期：2002-12-13 00:00:00

  • Convergence of cardiac and cutaneous afferents onto neurons in the dorsal horn of the spinal cord in the cat.

    abstract：:Convergence of cardiac and cutaneous afferents onto neurons in the dorsal horn of the spinal cord was demonstrated in the cat. Responses of neurons to cutaneous stimulation revealed that they were either nociceptive specific (NS) or wide dynamic range (WDR) neurons. NS neurons were located in lamina I and outer zone o...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(83)90377-4

    authors： Takahashi M,Yokota T

    更新日期：1983-08-08 00:00:00

  • Upper frequency limits of bilateral coordination patterns.

    abstract：:This study examined what changes occur in upper-limb bilateral coordination during clapping as the movement frequency requirements were increased to the maximum. Subjects were required to begin the clapping action at approximately 1Hz and gradually increase the movement speed until their maximal frequency was achieved...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.03.036

    authors： Morrison S,Hong SL,Newell KM

    更新日期：2009-05-01 00:00:00

  • Placebo effects: From pain to motor performance.

    abstract：:The placebo effect can be elicited by two main mechanisms: via classical conditioning and cognitive expectations. These two mechanisms have been traditionally investigated in one single domain. The aim of the present study is to investigate how a placebo effect obtained in one modality (pain tolerance) can be transfer...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neulet.2016.08.046

    authors： Carlino E,Guerra G,Piedimonte A

    更新日期：2016-10-06 00:00:00

  • An efficient and non-enzymatic method for isolation and culture of endothelial cells from the nidus of human cerebral arteriovenous malformations.

    abstract：:In this report, we describe an efficient and non-enzymatic method for isolating and culturing endothelial cells (ECs) from the nidus of surgically resected arteriovenous malformation (AVM) specimens. These cultured cells possessed typical phenotypic markers (i.e. von Willebrand factor and CD34), as well as morphologic...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2013.05.050

    authors： Zhang HF,Liang GB,Zhao MG,Song ZQ,Xu ZH

    更新日期：2013-08-26 00:00:00

  • Learning may reduce neurogenesis in adult rat dentate gyrus.

    abstract：:Neuron production carries on throughout adult life in granule cell layer of mammalian dentate gyrus. The acquisition of a hippocampus-dependent task enhances newborn cell survival in granule cell layer (GCL) during the period in which several newborn cells die. In this paper the effect of learning, occurring after the...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.12.123

    authors： Ambrogini P,Orsini L,Mancini C,Ferri P,Ciaroni S,Cuppini R

    更新日期：2004-04-08 00:00:00

  • Organization of sensory neurons to the muscles of mastication in the cat.

    abstract：:The sensory neurons in the trigeminal ganglion which project to the muscles of mastication of the cat were studied using the retrograde transport of horseradish peroxidase. Horseradish peroxidase either was injected directly into the masticatory muscles or applied to the nerves supplying them. Numerous retrogradely la...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90575-6

    authors： Martin JW,Panneton WM

    更新日期：1986-10-20 00:00:00

  • Glutamate N-methyl-D-aspartate receptor blockade prevents induction of GAP-43 after focal ischemia in rats.

    abstract：:Growth associated protein-43 (GAP-43) gene induction may be involved in reactive events that follow cerebral ischemic damage. Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors are thought to ameliorate functional outcome after ischemic injury. To assess whether glutamate NMDA receptor bloc...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)01833-x

    authors： Luque JM,Puig N,Martínez JM,González-García C,Ceña V

    更新日期：2001-06-08 00:00:00

  • Differential time course and intensity of PFC activation for men and women in response to emotional stimuli: a functional near-infrared spectroscopy (fNIRS) study.

    abstract：:Using functional near-infrared spectroscopy (fNIRS) we recorded prefrontal cortex (PFC) activation during positive, negative and neutral film clips, based on affective ratings according to their valence and arousal, to assess gender differences in cerebral activation in 15 male and 15 female volunteers. To record PFC ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.04.050

    authors： Leon-Carrion J,Damas J,Izzetoglu K,Pourrezai K,Martín-Rodríguez JF,Barroso y Martin JM,Dominguez-Morales MR

    更新日期：2006-07-31 00:00:00