Neuromelanic pigment in substantia nigra neurons of rats and dogs.

Abstract:

:The presence of neuromelanic pigment in neurons of the rat substantia nigra (SN) is a matter of controversy. The presence of neuromelanin in the SN of 15--24-month-old rats was investigated by electron microscopy (EM) and the findings compared to the morphology and distribution of neuromelanin in SN of dogs. In the rat, EM examination revealed a few small, evenly distributed neuromelanic granules in only 5% of nigral neurons. Dogs of 1 year of age showed a similar pattern; however, SN from adult and aged dogs exhibited abundant and larger neuromelanin granules which were also detectable by light microscopy. It is concluded that scanty neuromelanin is detectable by EM in rat SN and that the content of this pigment increases with age. The documented paucity of neuromelanin in rat SN neurons may explain why higher doses and longer treatment with MPTP is required in rats to obtain biochemical and behavioral signs of nigrostriatal dysfunction in this species.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

DeMattei M,Levi AC,Fariello RG

doi

10.1016/0304-3940(86)90614-2

subject

Has Abstract

pub_date

1986-12-03 00:00:00

pages

37-42

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(86)90614-2

journal_volume

72

pub_type

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