Abstract:
:A neurogenic contribution to joint inflammation has been demonstrated in rat adjuvant arthritis, however as inflammatory mechanisms vary between species it is unclear whether these observations can be applied more generally. The aim of this study was to assess the neurogenic contribution to cellular infiltration and other outcome measures in a guinea pig model of arthritis. Compared to arthritic controls, animals pre-treated with capsaicin at doses sufficient to reduce sensory activity exhibited a significant attenuation of both mechanical and thermal hyperalgesia. Measures of inflammation, including swelling and radiological scores were also improved. Furthermore, capsaicin selectively reduced synovial T cell infiltration whereas no difference was seen with respect to synovial macrophages. These observations confirm a neurogenic component in guinea pig arthritis and indicate a selective sensory influence on T cell activity within the chronically inflamed joint. As T cells are strongly implicated in the pathogenesis of rheumatic disease, such an influence may serve to explain some of the clinical features observed in these disorders.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hood VC,Cruwys SC,Urban L,Kidd BLdoi
10.1016/s0304-3940(00)01790-0keywords:
subject
Has Abstractpub_date
2001-02-23 00:00:00pages
201-4issue
3eissn
0304-3940issn
1872-7972pii
S0304394000017900journal_volume
299pub_type
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