Abstract:
:Numerous studies have provided evidence for a genetic association of the Apolipoprotein E (ApoE) epsilon4 allele and late onset familial and sporadic Alzheimer's disease (AD). Clinical observations show that a proportion of schizophrenic patients may suffer from severe cognitive impairment. That could reflect a particular clinical aspect of this mental disorder or a common, yet unknown, neurodegenerative mechanism. We analysed the ApoE gene polymorphism in a sample of 69 Italian patients with schizophrenia, 140 AD patients and 121 controls. In schizophrenic patients, the distribution of ApoE genotypes does not significantly differ from that of controls. No effect of the ApoE genotype on age of onset was found. The frequency of ApoE alleles in Italian schizophrenic patients is comparable with control values, suggesting that ApoE polymorphism does not represent a risk factor for schizophrenia.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sorbi S,Nacmias B,Tedde A,Latorraca S,Forleo P,Guarnieri BM,Petruzzi C,Daneluzzo E,Ortenzi L,Piacentini S,Amaducci Ldoi
10.1016/s0304-3940(98)00144-xsubject
Has Abstractpub_date
1998-03-13 00:00:00pages
118-20issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00144-Xjournal_volume
244pub_type
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