No implication of apolipoprotein E polymorphism in Italian schizophrenic patients.

Abstract:

:Numerous studies have provided evidence for a genetic association of the Apolipoprotein E (ApoE) epsilon4 allele and late onset familial and sporadic Alzheimer's disease (AD). Clinical observations show that a proportion of schizophrenic patients may suffer from severe cognitive impairment. That could reflect a particular clinical aspect of this mental disorder or a common, yet unknown, neurodegenerative mechanism. We analysed the ApoE gene polymorphism in a sample of 69 Italian patients with schizophrenia, 140 AD patients and 121 controls. In schizophrenic patients, the distribution of ApoE genotypes does not significantly differ from that of controls. No effect of the ApoE genotype on age of onset was found. The frequency of ApoE alleles in Italian schizophrenic patients is comparable with control values, suggesting that ApoE polymorphism does not represent a risk factor for schizophrenia.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Sorbi S,Nacmias B,Tedde A,Latorraca S,Forleo P,Guarnieri BM,Petruzzi C,Daneluzzo E,Ortenzi L,Piacentini S,Amaducci L

doi

10.1016/s0304-3940(98)00144-x

subject

Has Abstract

pub_date

1998-03-13 00:00:00

pages

118-20

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(98)00144-X

journal_volume

244

pub_type

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