Increase in substance P and CGRP, but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat.

Abstract:

:Neuropeptides, synthesized in dorsal root ganglia (DRG), are implicated in nociception and neurogenic inflammation. Alterations in DRG neuropeptide levels have been described in polyarthritic rats, but these models are associated with widespread systemic disease. Using mild adjuvant-mediated monoarthritis of the left carpal joint we found significant increases in substance P (+69%) and calcitonin gene-related peptide (CGRP; +204+), but not somatostatin in ipsilateral C6/7 DRG. Peptide levels in contralateral DRG and other ipsilateral DRG were unaltered. Substance P and CGRP in DRG may be of importance in the pathogenesis and maintenance of adjuvant arthritis.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Smith GD,Harmar AJ,McQueen DS,Seckl JR

doi

10.1016/0304-3940(92)90417-6

keywords:

subject

Has Abstract

pub_date

1992-03-30 00:00:00

pages

257-60

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90417-6

journal_volume

137

pub_type

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