Abstract:
:Neuropeptides, synthesized in dorsal root ganglia (DRG), are implicated in nociception and neurogenic inflammation. Alterations in DRG neuropeptide levels have been described in polyarthritic rats, but these models are associated with widespread systemic disease. Using mild adjuvant-mediated monoarthritis of the left carpal joint we found significant increases in substance P (+69%) and calcitonin gene-related peptide (CGRP; +204+), but not somatostatin in ipsilateral C6/7 DRG. Peptide levels in contralateral DRG and other ipsilateral DRG were unaltered. Substance P and CGRP in DRG may be of importance in the pathogenesis and maintenance of adjuvant arthritis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Smith GD,Harmar AJ,McQueen DS,Seckl JRdoi
10.1016/0304-3940(92)90417-6keywords:
subject
Has Abstractpub_date
1992-03-30 00:00:00pages
257-60issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(92)90417-6journal_volume
137pub_type
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