Abstract:
:In an attempt to elucidate the possible mechanisms involved in the development of the thermoregulatory disturbances induced by systemic capsaicin treatment, the effects of 5-HT injected into the preoptic region or into the cisterna magna on the body temperature and on tail skin vasodilation were studied in control and capsaicin-treated rats. Intracisternal 5-HT elicited a comparable decrease in body temperature in both groups of animals. In contrast, intrapreoptic injection of different doses of 5-HT-induced tail skin vasodilation and hypothermia in the controls, but not in the capsaicin-treated rats. It is suggested that changes in the sensitivity of preoptic warm-responsive structures to 5-HT may contribute essentially to the specific thermoregulatory impairment brought about by systemic capsaicin treatment.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hajós M,Obál F Jr,Jancsó G,Obál Fdoi
10.1016/s0304-3940(85)80124-5subject
Has Abstractpub_date
1985-02-28 00:00:00pages
97-102issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(85)80124-5journal_volume
54pub_type
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