Abstract：
OBJECTIVE:Diabetic neuropathic pain (DNP) is one of the most common and severe complications in patients with diabetes. This study aimed to investigate serum brain-derived neurotrophic factor (BDNF) levels in patients with DNP and to evaluate the association between BDNF and disease severity. METHODS:A total of 143 T2DM patients were included, according to clinical characteristics and douleur neuropathique 4 (DN4) questionnaire are divided into the DNP group (n = 78) and without the DNP group (n = 65). BDNF levels were measured by an enzyme-linked immunosorbent assay. Additionally, other biochemical characteristics were measured using routine laboratory methods. RESULTS:Serum levels of BDNF was increased significantly in the DNP group compared to without DNP group. Meanwhile, a binary logistic regression model identified as revealed BDNF (OR = 1.178, 95%CI = 1.064-1.305,p = 0.002) was a risk factor in T2DM patients. Furthermore, the serum BDNF levels positively correlated with VAS score in the DNP patients. CONCLUSIONS:Serum BDNF was elevated in DNP patients and increased gradually with the VAS score. BDNF was identified as risk factors for pain in all T2DM patients.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Wang Z,Li Hdoi
10.1016/j.neulet.2021.135655subject
Has Abstractpub_date
2021-01-21 00:00:00pages
135655eissn
0304-3940issn
1872-7972pii
S0304-3940(21)00033-1pub_type
杂志文章abstract：:The extent to which N-Methyl-d-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. In so, we utilized female Wistar rats selectively bred to voluntarily run high (HVR) and low (LVR) nightly distances in order to examine if endogenous differences in nucleus...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.02.011
更新日期：2018-04-03 00:00:00
abstract：:Insulin-like growth factor-1 (IGF1) and its active peptide (1-3)IGF1 modulate brain growth and plasticity and are candidate molecules for treatment of brain disorders. IGF1 N-terminal portion is naturally cleaved to generate the tri-peptide (1-3)IGF1 (glycine-praline-glutamate). IGF1 and (1-3)IGF have been proposed as...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.05.029
更新日期：2012-06-27 00:00:00
abstract：:In mammals, methyl-CpG binding proteins play a significant role in the control of gene expression through their association with chromatin-remodeling complexes. Mutations in the gene coding for methyl-CpG-binding protein 2 (MECP2) cause Rett syndrome and have also been reported in a number of X-linked mental retardati...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.12.036
更新日期：2005-04-29 00:00:00
abstract：:The vertebrate retina is known to mediate both visual and non-image-forming photic responses. With the use of statistical analyses of sections immunohistochemically labelled with a polyclonal antiserum against the activated form of protein CREB (p-CREB), a transcription factor which participates in some neural respons...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.12.099
更新日期：2004-03-11 00:00:00
abstract：:Adenosine has been proposed to be a chemical link between cerebral metabolism and blood flow. In the present study, we investigated whether the intravenous or intracarotid administration of adenosine could influence regional cerebral blood flow in anesthetized rabbits. The study was performed with the [14C]ethanol tis...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90658-6
更新日期：1987-09-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90076-6
更新日期：1988-11-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.06.009
更新日期：2017-07-13 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00275-x
更新日期：1999-05-14 00:00:00
abstract：:This article has been withdrawn at the request of the Editor-in-Chief. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
journal_title：Neuroscience letters
pub_type： 撤回出版物
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更新日期：2020-07-02 00:00:00
abstract：BACKGROUND:A single session of aerobic exercise is linked to faster motor responses; however, the effect on rate of short-term learning is less clear. The objective was to evaluate the influence of a single bout of aerobic exercise on the rate of short-term acquisition of a shape-letter association task requiring a mot...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.06.064
更新日期：2016-08-26 00:00:00
abstract：:This is a short report confirming recent articles that birds are very likely involved as vectors of the exogenous causative agent of multiple sclerosis (MS). It also critically reviews the most recent article (MacGregor, H. and Latiwonk, Q., Neurol. Res., 15 (1993) 391-394.) in which a high percentage of serums from M...
journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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更新日期：1995-03-24 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90248-8
更新日期：1990-10-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2019.04.058
更新日期：2019-07-13 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90562-y
更新日期：1993-11-12 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00108-6
更新日期：1998-03-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.11.029
更新日期：2011-01-20 00:00:00
abstract：:The localization of cells which produce estrogen receptors in the rat central nervous system was performed using an in situ hybridization technique. For this, we used a synthetic oligonucleotide probe labeled with 35S complementary to the mRNA coding for a fragment (1-24) of estradiol receptor which is not common to t...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90264-9
更新日期：1988-11-22 00:00:00
abstract：:The effects of maternal deprivation (MD) during early postnatal life on the brain-derived neurotrophic factor (BDNF) level were investigated in the present study. Wistar rats were assigned to either maternal deprivation or mother-reared control (MRC) groups. MD manipulation was achieved by separating rat pups from the...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.09.012
更新日期：2004-11-30 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90656-r
更新日期：1992-02-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90176-9
更新日期：1984-12-21 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90122-3
更新日期：1985-05-14 00:00:00
abstract：:The present study investigates the effect of cognitive reappraisal on emotion regulation in socially anxious individuals. Twenty-eight female subjects were divided into high-socially anxious (HSA) and low-socially anxious (LSA) groups. All subjects viewed threatening faces under cognitive reappraisal and passive viewi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.06.006
更新日期：2014-08-08 00:00:00
abstract：:In astrocytes, ion currents are predominantly carried by K(+) ions, and their potassium channel expression changes during development. Here, we studied ion current generated by voltage-ramp protocols in cultured astrocytes from the corpus callosum of newborn (P0) and 28-day-old (P28) rats. Inward currents measured at ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.09.009
更新日期：2010-11-26 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)00232-2
更新日期：1997-04-18 00:00:00
abstract：:The expression of neuronal type of nitric oxide synthase (nNOS) has been studied by immunocytochemistry in the brain of rats receiving a single daily (for up to 14 consecutive days) intracerebroventricular (i.c.v.) injection of the HIV-1 recombinant protein gp 120 (100 ng/day). This treatment failed to affect nNOS exp...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)13463-2
更新日期：1997-03-14 00:00:00
abstract：:Previously we have shown that the 6-sulphatoxymelatonin rhythm of oil rig workers on a 2-week night shift (1800-0600 h) adapts to the shift via a phase delay. We now report the findings of a study on two offshore drill crews working a 1 week day (1200-0000 h), 1 week night (0000-1200 h) swing shift. Urine samples were...
journal_title：Neuroscience letters
pub_type： 临床试验,杂志文章
doi：10.1016/s0304-3940(98)00585-0
更新日期：1998-08-21 00:00:00
abstract：:Rhythmic arm movement significantly suppresses H-reflex amplitude in the soleus (SOL) muscle. This is evidence of neural linkages between the arms and legs which can be exploited during locomotion and have been ascribed to the descending effects of CPGs for arm cycling. However, the generalizability of the effects of ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.11.034
更新日期：2009-02-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90549-5
更新日期：1986-11-11 00:00:00
abstract：:The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of extracellular amyloid-beta peptide (Abeta) in the form of amyloid plaques in the brain parenchyma and neuronal loss. The mechanism associated with neuronal death by amyloid plaques is unclear but oxidative stress and glial activation h...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.06.045
更新日期：2010-08-30 00:00:00
abstract：:The left adrenal gland of the rat was perfused in vitro via the adrenal vein with Krebs-bicarbonate solution to study accumulation of exogenous catecholamines and secretion of endogenous norepinephrine and epinephrine by exposing the gland to various sympathomimetic agents. Perfusions with high concentrations of norep...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90476-2
更新日期：1984-09-07 00:00:00
