N-linked oligosaccharides are not required for neuron-neuron interactions mediated by neural cell adhesion molecule.

Abstract:

:Recent studies have described the role of various regions of the neural cell adhesion molecule (NCAM) in cell-cell interactions. Monoclonal antibodies (L2/HNK-1) directed against a sulfated, glucuronic acid-containing, N-linked carbohydrate epitope have also been shown to inhibit NCAM-mediated neural cell adhesion. In the present study we show that dissociated retinal neurons in an in vitro model system can bind as well to normal NCAM as to NCAM lacking the L2/HNK-1 epitope or to glycopeptidase F-treated NCAM. These data suggest that N-linked oligosaccharide chains do not confer upon NCAM the adhesional properties associated with its role in neuron-neuron interactions.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Cole GJ,Schachner M,Fliesler SJ

doi

10.1016/0304-3940(88)90076-6

subject

Has Abstract

pub_date

1988-11-11 00:00:00

pages

170-5

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(88)90076-6

journal_volume

93

pub_type

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