Abstract:
:Recent studies have described the role of various regions of the neural cell adhesion molecule (NCAM) in cell-cell interactions. Monoclonal antibodies (L2/HNK-1) directed against a sulfated, glucuronic acid-containing, N-linked carbohydrate epitope have also been shown to inhibit NCAM-mediated neural cell adhesion. In the present study we show that dissociated retinal neurons in an in vitro model system can bind as well to normal NCAM as to NCAM lacking the L2/HNK-1 epitope or to glycopeptidase F-treated NCAM. These data suggest that N-linked oligosaccharide chains do not confer upon NCAM the adhesional properties associated with its role in neuron-neuron interactions.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cole GJ,Schachner M,Fliesler SJdoi
10.1016/0304-3940(88)90076-6subject
Has Abstractpub_date
1988-11-11 00:00:00pages
170-5issue
2-3eissn
0304-3940issn
1872-7972pii
0304-3940(88)90076-6journal_volume
93pub_type
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