Abstract:
:Amphiphysin II (Amph2) is known to undergo rapid dephosphorylation and phosphorylation at nerve terminals. After in vivo electroconvulsive shock (ECS) in the rat cerebellum, we found an electrophoretic mobility retardation of Amph2, which suggested an increased degree of phosphorylation above the non-stimulated level. This shifted signal was observed from 1 min, reached the maximum level at 5 min and extended beyond 2 h after ECS. The shifted band was markedly decreased by the phosphatase treatment. Pretreatment with cyclosporin A augmented the mobility retardation of Amph2 after ECS. Our results indicate that ECS induces the phosphorylation of Amph2 in the rat cerebellum.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Koo YJ,Kim SJ,Jeon SH,Kim SR,Kang UG,Park JB,Kim YSdoi
10.1016/s0304-3940(02)00748-6keywords:
subject
Has Abstractpub_date
2002-09-20 00:00:00pages
135-8issue
2eissn
0304-3940issn
1872-7972pii
S0304394002007486journal_volume
330pub_type
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