Abstract:
:Thioredoxin (TRX) is a small, multifunctional protein with a redox-active site and multiple biological functions that include reducing activity for reactive oxygen intermediates. We assayed TRX by immunohistochemical methods in the rat brain after intraperitoneal injection of 3-nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase. Systemic administration of 3-NP produced lateral striatal, hippocampal CA1 and CA3 lesions in the present study. The immunoreactivity for TRX was enhanced in hippocampal CA3, dentate gyrus and lateral striatum, but not detected in hippocampal CA1 subfield after 3-NP intoxication. The data suggest that TRX may play an important role in the pathogenesis of 3-NP neurotoxicity.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sugino T,Nozaki K,Takagi Y,Hattori I,Hashimoto N,Yodoi Jdoi
10.1016/s0304-3940(99)00763-6keywords:
subject
Has Abstractpub_date
1999-11-12 00:00:00pages
145-8issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00763-6journal_volume
275pub_type
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