Abstract:
:After hypoxic-ischemic insult iron deposited in the brain catalyzes formation of reactive oxygen species. Newborn rats, showing reduced physiological body temperature and their hyperthermic counterparts injected with deferoxamine (DF), a chelator of iron, are protected both against iron-mediated neurotoxicity and against depletion of low-molecular antioxidants after perinatal asphyxia. Therefore, we decided to study the effects of DF on activity of antioxidant enzymes (superoxide dismutase-SOD, glutathione peroxidase-GPx and catalase-CAT) in the brain of rats exposed neonatally to a critical anoxia at body temperatures elevated to 39°C. Perinatal anoxia under hyperthermic conditions intensified oxidative stress and depleted the pool of antioxidant enzymes. Both the depletion of antioxidants and lipid peroxidation were prevented by post-anoxic DF injection. The present paper evidenced that deferoxamine may act by recovering of SOD, GPx and CAT activity to reduce anoxia-induced oxidative stress.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kletkiewicz H,Nowakowska A,Siejka A,Mila-Kierzenkowska C,Woźniak A,Caputa M,Rogalska Jdoi
10.1016/j.neulet.2016.06.022subject
Has Abstractpub_date
2016-08-15 00:00:00pages
116-22eissn
0304-3940issn
1872-7972pii
S0304-3940(16)30431-1journal_volume
628pub_type
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