Sustained expression of functional nerve growth factor in primary septo-hippocampal cell cultures by liposome-mediated gene transfer.

abstract：:CREATE (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) is a pedagogical approach for teaching and learning science through the rigorous analysis of primary scientific literature. This mini-review focuses on the tools, assignments, and in-class activities by which this s...

journal_title：Neuroscience letters

authors： Pugh-Bernard A,Kenyon KL

更新日期：2021-01-18 00:00:00

abstract：:The membrane mechanisms associated with Cl- conductance activated by GABA in spinal and hippocampal neurons cultured from the embryonic mouse and rat have been studied with voltage- and patch-clamp techniques. The elementary mechanism underlying the conductance response is predominantly all-or-none with both similar a...

journal_title：Neuroscience letters

authors： Barker JL,Owen DG,Segal M

更新日期：1984-06-29 00:00:00

abstract：:The aim of the present study was to investigate the moderating effect of intolerance of uncertainty (IU) on exposure to aversion and its anticipation using event-related potentials (ERPs). Sixteen subjects high in IU and 16 subjects low in IU underwent an affective cueing paradigm where a warning cue signaled the vale...

journal_title：Neuroscience letters

authors： Gole M,Schäfer A,Schienle A

更新日期：2012-01-24 00:00:00

abstract：:The transcriptional regulation of the gene encoding α-synuclein (SNCA) is thought to play a critical role in the pathogenesis of Parkinson's disease (PD), as common genetic variability in this gene is associated with an elevated risk of developing PD. However, the relevant mechanisms are still poorly understood. So fa...

journal_title：Neuroscience letters

authors： Brenner S,Wersinger C,Gasser T

更新日期：2015-07-10 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA, 500 ng/0.5 microliters), alpha-amino-3-hydroxy-5-methyl-4-isoxasole-propionic acid (AMPA, 1000 ng/0.5 microliters), or kainic acid (50 ng/0.5 microliters) injected into intermediate and caudal parts of the caudate-putamen induced contralateral head turns and rotations. Picrotoxin (250 ng/0....

journal_title：Neuroscience letters

authors： Ossowska K

更新日期：1995-12-29 00:00:00

abstract：:Findings from preclinical and clinical research support the involvement of central noradrenergic dysregulation in the etiology of attention deficit hyperactivity disorder (ADHD). Previous studies have suggested that the alpha-2C-adrenergic receptor gene (ADRA2C) is associated with ADHD. The aims of this study were to ...

journal_title：Neuroscience letters

authors： Cho SC,Kim JW,Kim BN,Hwang JW,Shin MS,Park M,Kim SA,Cho DY,Yoo HJ,Chung US,Son JW,Park TW

更新日期：2008-12-03 00:00:00

abstract：:Dual innervation, two morphologically distinct axons ending on the same endplate of white muscle, has been observed in some 'primitive' fish but not 'higher' teleosts. A representative of the order Bachtrachoidiformes, Opsanus tao, was examined using histological sectioning and silver impregnation to determine the inn...

journal_title：Neuroscience letters

authors： Raso DS

更新日期：1990-08-24 00:00:00

abstract：:To determine the role of cytokines in the nervous system, we examined the effect of interleukin-12(IL-12) on the nerve regeneration of mouse superior cervical ganglion cells (SCG). IL-12 enhanced the neurite outgrowth in a concentration-dependent manner. Immunocytochemical studies demonstrated the expression of IL-12 ...

journal_title：Neuroscience letters

authors： Lin H,Hikawa N,Takenaka T,Ishikawa Y

更新日期：2000-01-14 00:00:00

abstract：:Opiate withdrawal syndrome is temporally associated with the hyperactivity of locus coeruleus neurons. Previous studies have shown that this hyperactivity, at least in part, results from the activity of excitatory afferents which mainly include the orexinergic neurons of hypothalamus and glutamatergic neurons of parag...

journal_title：Neuroscience letters

authors： Hooshmand B,Azizi H,Javan M,Semnanian S

更新日期：2017-01-01 00:00:00

abstract：:The accumulation of choline acetyltransferase (CAT) proximal to and nerve growth factor (NGF) distal to the intraneural site of tetrodotoxin (TTX) or batrachotoxin (BTX) injection in vivo was used to monitor orthograde and retrograde axonal transport. Orthograde axonal transport was blocked by BTX for up to 7-10 days ...

journal_title：Neuroscience letters

authors： Boegman RJ,Riopelle RJ

更新日期：1980-06-01 00:00:00

abstract：:Nerve growth factor (NGF) initially interested neurobiologists because of its effects in the developing nervous system. It is now clear that NGF functions throughout the life of the animal with a wide repertoire of actions. In the sensory nervous system it primarily influences the structure and function of nociceptors...

journal_title：Neuroscience letters

authors： Petruska JC,Mendell LM

更新日期：2004-05-06 00:00:00

abstract：:There is a growing body of evidence that the ventromedial prefrontal cortex (VMPFC) is implicated in the new learning of visual items. Little is known, however, as to the involvement of that portion of the prefrontal cortex in the learning of temporal and spatial relationship of those items. The aim of the present stu...

journal_title：Neuroscience letters

authors： Szatkowska I,Szymańska O,Grabowska A

更新日期：2004-07-01 00:00:00

abstract：:The effect of diabetes on periaqueductal gray matter (PAG) stimulation-produced analgesia (SPA) was examined in rats. PAG SPA was assessed using the tail-pinch test. PAG stimulation produced marked analgesia in both naive and diabetic rats. Furthermore, the degree of PAG SPA did not differ between naive and diabetic r...

journal_title：Neuroscience letters

authors： Kamei J,Aoki T,Kasuya Y

更新日期：1992-08-03 00:00:00

abstract：:Free radical generation and release from the cerebral hemispheres of rats subjected to four-vessel occlusion elicited cerebral ischemia/reperfusion was monitored using a cortical cup technique with the spin-trapping agent alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN). Electron spin resonance (ESR) was used to d...

journal_title：Neuroscience letters

authors： Phillis JW,Sen S,Cao X

更新日期：1994-03-14 00:00:00

abstract：:beta-N-Oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA) were tested for their ability to produce acute excitotoxicity in in embryonic chick retina. gamma-Aminobutyric acid (GABA) release and histology were monitored in retina treated with various concentrations of BOAA, BMAA, kainate (KA), N-methyl...

journal_title：Neuroscience letters

authors： Zeevalk GD,Nicklas WJ

更新日期：1989-07-31 00:00:00

abstract：:Morphine blocked decremental bar pressing of rats to escape electrical stimulation of aversive midbrain sites. These sites included the dorsal central gray area (DCG), the ventral reticular formation (VRF) and the lateral tegmentum (LT). Naloxone, which had no effect alone, blocked the morphine effects of all three av...

journal_title：Neuroscience letters

authors： Kiser RS,German DC

更新日期：1978-11-01 00:00:00

abstract：:Repetitive ischemia causes more severe damage than a single insult of comparable duration. Gerbils were followed for 1 month postrepetitive ischemia and 100% mortality was demonstrated in the unprotected ischemia group by 12 days postischemia. Significant protection against mortality due to repetitive ischemia was off...

journal_title：Neuroscience letters

authors： McCrea S,Shuaib A,Wishart T,Ijaz S

更新日期：1994-03-28 00:00:00

abstract：:We examined Na+,K(+)-ATPase activity in four regions of the gerbil cochlear lateral wall by measuring intracellular Na+ concentration ([Na+]i). The application of 1 mM ouabain and removal of external K+ caused a most striking increase in [Na+]i of the suprastrial fibrocytes, followed by the stria vascularis and the ty...

journal_title：Neuroscience letters

authors： Furukawa M,Ikeda K,Takeuchi S,Oshima T,Kikuchi T,Takasaka T

更新日期：1996-08-09 00:00:00

abstract：:The presence of a novel member of serine proteinase inhibitor, B-43, was immunohistochemically indicated in both neurons and astrocytes in the parietal region of the bovine brain. B-43-like immunoreactivity was detected in pyramidal cells in the cortex and GFAP-positive astroglial cells in the white matter. The proces...

journal_title：Neuroscience letters

authors： Nishibori M,Ohtsuka A,Kawabata M,Nakaya N,Murakami T,Saeki K

更新日期：1995-11-17 00:00:00

abstract：:Recent evidence has suggested that down-regulation of somatostatin (SST) expression in the human brain during early stages of aging leads to an elevation in the steady-state levels of Abeta and therefore may be involved in Alzheimer's disease (AD) progression. We hypothesized that alterations in the SST gene might alt...

journal_title：Neuroscience letters

authors： Xue S,Jia L,Jia J

更新日期：2009-11-13 00:00:00

abstract：:Silent synapses display no excitatory post-synaptic currents (EPSCs) at resting potentials, but can conduct at depolarized potentials. In the hippocampal CA1 region of young animals, conversion of silent synapses to functional synapses occurs rapidly after pairing post-synaptic depolarization with 1Hz pre-synaptic sti...

journal_title：Neuroscience letters

authors： Kasten MR,Fan Y,Schulz PE

更新日期：2007-04-24 00:00:00

abstract：:Since calcium homeostasis is altered in cultured skin fibroblasts from aged and Alzheimer donors, the present study examined the degradation of spectrin, a substrate of the calcium dependent protease calpain. Spectrin proteolysis was estimated as the percentage of spectrin breakdown products (e.g., 150 + 155 kDa bands...

journal_title：Neuroscience letters

authors： Peterson C,Vanderklish P,Seubert P,Cotman C,Lynch G

更新日期：1991-01-02 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) is known as a neuro-survival factor in the developing and developed CNS, as well as in the CNS following injury. However, little is known about the expression of CNTF or that of its receptor (CNTFR-alpha) in cases of intracerebral hemorrhage (ICH). We investigated the temporal and sp...

journal_title：Neuroscience letters

authors： Yokota H,Yoshikawa M,Hirabayashi H,Nakase H,Uranishi R,Nishimura F,Sugie Y,Ishizaka S,Sakaki T

更新日期：2005-04-04 00:00:00

abstract：:'Reverspectives' (by artist Patrick Hughes) consist of truncated pyramids with their small faces closer to the viewer, allowing realistic scenes to be painted on them. Because their pictorial perspective reverses the physical depth arrangement, reverspectives provide a bistable paradigm of two radically different, com...

journal_title：Neuroscience letters

authors： Wagner M,Ehrenstein WH,Papathomas TV

更新日期：2009-01-09 00:00:00

abstract：:Deep brain stimulation (DBS) is now emerging as a new option for treating intractable epilepsy. Cumulative studies suggest that the mediodorsal thalamic nucleus (MD) is involved in limbic seizure activity. This study aims to investigate whether DBS of the MD can protect against seizures induced by amygdaloid kindling....

journal_title：Neuroscience letters

authors： Wang S,Wu DC,Fan XN,Zhu MZ,Hu QY,Zhou D,Ding MP,Chen Z

更新日期：2010-09-06 00:00:00

abstract：:We have studied the electrophysiological properties of enzymatically dissociated adult pigeon semicircular canal type I (chalice shaped) and type II (cylindrical shaped) hair cells using whole cell patch clamp techniques. Under current clamp conditions, type I hair cells often exhibit more hyperpolarized resting poten...

journal_title：Neuroscience letters

authors： Correia MJ,Lang DG

更新日期：1990-08-14 00:00:00

abstract：:Previous studies using various excitatory amino acid antagonists have shown that synaptic transmission between the auditory nerve and the cochlear nucleus of chickens (nuc. magnocellularis; NM) is mediated by non-N-methyl-D-aspartate (non-NMDA) receptors. In the present study we have attempted to define the subclass o...

journal_title：Neuroscience letters

authors： Nemeth EF,Jackson H,Parks TN

更新日期：1985-09-06 00:00:00

abstract：:Scalp acupuncture (SA) therapy on strokes has been empirically established and widely used in clinics in China. SA is particularly effective at ameliorating paralyses and speech disturbances, and the recovery rate is twice that for those treated with medication alone. To investigate the effects of SA on a scientific b...

journal_title：Neuroscience letters

authors： Inoue I,Chen L,Zhou L,Zeng X,Wang H

更新日期：2002-11-29 00:00:00

abstract：:Activation of serotonin (5-hydroxytryptamine, 5-HT) receptors produces various autonomic and neuroendocrine responses in the hypothalamic paraventricular nucleus (PVN), including increased blood pressure and heart rate. However, the role(s) of 5-HT on the local GABA synaptic circuit have not been well understood in th...

journal_title：Neuroscience letters

authors： Lee KS,Han TH,Jo JY,Kang G,Lee SY,Ryu PD,Im JH,Jeon BH,Park JB

更新日期：2008-07-11 00:00:00

abstract：:By studying the binding of [3H]glycine and [3H]glutamate to rat synaptic membranes in the presence of 2-amino-5-phosphonovalerate (APV) and kynurenate (KYN) we have demonstrated that KYN is more potent than APV in displacing [3H]glycine, while an opposite order of potency was seen in displacing [3H]glutamate. Moreover...

journal_title：Neuroscience letters

authors： Danysz W,Fadda E,Wroblewski JT,Costa E

更新日期：1989-01-30 00:00:00