Abstract:
:To determine the role of cytokines in the nervous system, we examined the effect of interleukin-12(IL-12) on the nerve regeneration of mouse superior cervical ganglion cells (SCG). IL-12 enhanced the neurite outgrowth in a concentration-dependent manner. Immunocytochemical studies demonstrated the expression of IL-12 receptors in neuronal bodies and neurites. The mRNA expression of IL-12 receptors in SCG cells was confirmed by reverse transcription-polymerase chain reaction. Our data demonstrated the presence of IL-12 receptors in sympathetic neurons and suggest that IL-12 plays an important role in neuronal regeneration.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lin H,Hikawa N,Takenaka T,Ishikawa Ydoi
10.1016/s0304-3940(99)00913-1keywords:
subject
Has Abstractpub_date
2000-01-14 00:00:00pages
129-32issue
3eissn
0304-3940issn
1872-7972pii
S0304394099009131journal_volume
278pub_type
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