Abstract:
:The effect of diabetes on periaqueductal gray matter (PAG) stimulation-produced analgesia (SPA) was examined in rats. PAG SPA was assessed using the tail-pinch test. PAG stimulation produced marked analgesia in both naive and diabetic rats. Furthermore, the degree of PAG SPA did not differ between naive and diabetic rats. PAG SPA was significantly attenuated by a low dose (0.5 mg/kg, s.c.) of naloxone in naive rats, but not in diabetic rats. However, a high dose (5 mg/kg, s.c.) of naloxone significantly and equally attenuated PAG SPA in both naive and diabetic rats. On the other hand, the analgesic potency of morphine (3 mg/kg, s.c.) was significantly reduced in diabetic rats as compared with naive rats. These results suggest that PAG SPA in diabetic rats may be mediated by different opioid receptor interactions as compared with naive rats.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kamei J,Aoki T,Kasuya Ydoi
10.1016/0304-3940(92)90609-bkeywords:
subject
Has Abstractpub_date
1992-08-03 00:00:00pages
13-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(92)90609-Bjournal_volume
142pub_type
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(79)95355-2
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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更新日期:1998-06-19 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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更新日期:1995-02-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/0304-3940(88)90426-0
更新日期:1988-02-15 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2009-01-16 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90537-1
更新日期:1994-10-24 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/0304-3940(94)90619-x
更新日期:1994-04-25 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)00925-3
更新日期:2000-04-07 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90235-1
更新日期:1986-07-11 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(80)90235-9
更新日期:1980-10-20 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.06.002
更新日期:2009-09-18 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02150-4
更新日期:2001-09-28 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2001-02-16 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1985-10-10 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.03.021
更新日期:2013-05-10 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.08.026
更新日期:2004-11-11 00:00:00