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Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population.

Abstract：

:Serotonin transporter gene may play a critical role in a regulation of mood and other aspects of mental status. A large number of association studies have investigated a correlation between the polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) and anxiety-related personality traits. The results, however, have been inconsistent. Heterogeneity of subjects regarding gender, occupation, social-class and other environmental factors, in addition to effects of other genes, might have confounded the results. Here, we studied an association between the 5-HTTLPR polymorphism and personality traits in primarily female (78%) healthy subjects (n=244), who had homogeneous backgrounds regarding ethnicity (Japanese) and occupation. Personality traits of the subjects were assessed with the revised NEO Personality Inventory. No significant association was observed between the polymorphism and neuroticism or other personality traits, in all subjects, all females (n=190) or female nurses (n=159). Thus, our findings provided no evidence for an association between the 5-HTTLPR polymorphism and anxiety-related or other personality traits.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Umekage T,Tochigi M,Marui T,Kato C,Hibino H,Otani T,Kohda K,Kato N,Sasaki T

doi

10.1016/s0304-3940(02)01291-0

keywords:

subject

Has Abstract

pub_date

2003-01-30 00:00:00

pages

13-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304394002012910

journal_volume

337

pub_type

杂志文章

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