Changes in rat hypothalamic and brain stem catecholamine concentrations following acute administration of phenylethanolamine-N-methyltransferase inhibitors.

abstract：:Abnormal neural activity generated at a site of nerve injury is thought to contribute to the development of dysaesthesia. Vanilloid receptor 1 (TRPV1), a transducer of noxious stimuli, may be involved in the initiation of this abnormal activity and could provide a useful therapeutic target. We investigated the effect ...

journal_title：Neuroscience letters

authors： Biggs JE,Yates JM,Loescher AR,Clayton NM,Robinson PP,Boissonade FM

更新日期：2008-09-26 00:00:00

abstract：:PC12 cells, a clonal cell line established from a rat pheochromocytoma, were injected into the subarachnoid space in the lumbar spinal cord of adult rats. These cells invaded the spinal cord as a metastatic tumor and, after 2 weeks, displaced one-third of the cord parenchyma, causing hind limb paralysis. The tumor con...

journal_title：Neuroscience letters

authors： Pappas GD,Sagen J

更新日期：1986-09-25 00:00:00

abstract：:Gene expression can be regulated by chromatin remodeling induced by the opposing actions of histone acetyltransferases and histone deacetylases (HDAC). HDAC inhibitors are considered putative anti-cancer drugs, but may also alter gene expression in the brain. Valproic acid (valproate; VPA), a drug used for treatment o...

journal_title：Neuroscience letters

authors： Yildirim E,Zhang Z,Uz T,Chen CQ,Manev R,Manev H

更新日期：2003-07-17 00:00:00

abstract：:Fear-conditioned analgesia (FCA) is modulated by brain areas involved in the descending inhibitory pain pathway such as the basolateral (BLA) and central amygdala (CEA). The BLA contains Ca2+/calmodulin-dependent protein kinase II (CaMKII) and parvalbumin (PV) neurons. CEA neurons are primarily inhibitory (GABAergic) ...

journal_title：Neuroscience letters

authors： Butler RK,Ehling S,Barbar M,Thomas J,Hughes MA,Smith CE,Pogorelov VM,Aryal DK,Wetsel WC,Lascelles BDX

更新日期：2017-11-20 00:00:00

abstract：:Aphasia is a highly disabling language disorder usually caused by a left stroke brain damage. Even if traditional language therapies have been proved to induce an adequate clinical recovery, a large percentage of patients are left with chronic deficits at 6 months post-stroke. Therefore, new strategies to common speec...

journal_title：Neuroscience letters

authors： Marangolo P

更新日期：2020-02-06 00:00:00

abstract：:The influence of monokines and CNS-derived colony-stimulating factors (CSF) on the growth of microglia has been studied in mixed glial primary cultures stemming from mouse embryos. We observed that spontaneous growth of microglial cells in the presence of astrocytes is blocked by adding anti-colony-stimulating factor ...

journal_title：Neuroscience letters

authors： Théry C,Mallat M

更新日期：1993-02-19 00:00:00

abstract：:Whole-cell recordings were obtained from respiratory neurons by applying patch-clamp techniques in the en bloc medulla of in vitro neonatal rat brainstem-spinal cord preparations. Stable voltage-clamp recordings of excitatory or inhibitory synaptic drive currents and current-clamp recordings of spike discharge of insp...

journal_title：Neuroscience letters

authors： Smith JC,Ballanyi K,Richter DW

更新日期：1992-01-06 00:00:00

abstract：:The fate of neural stem/progenitor cells (NSCs/NPCs) in vivo lies on the local microenvironment. Whether the denervated hippocampus provides a stimulative role on the survival and differentiation of the anterior subventricular zone (SVZa) progenitors was investigated in the present study. In vivo the SVZa progenitors ...

journal_title：Neuroscience letters

authors： Zhang X,Jin G,Tian M,Qin J,Huang Z

更新日期：2007-03-06 00:00:00

abstract：:To verify the hypothesis that the control of movement by the cortical masticatory area (CMA) is particularly important at the beginning of the mastication, we compared movements before and after bilateral CMA ablation. After ablation, the animal could not manipulate food placed in the front of the mouth for several da...

journal_title：Neuroscience letters

authors： Enomoto S,Schwartz G,Lund JP

更新日期：1987-11-23 00:00:00

abstract：:Calcium homeostasis in synaptosomes is altered during ageing. The cytosolic free calcium concentration, [Ca2+]i was determined in synaptosomes and crude synaptosomal fractions from 3- and 24-month-old rats with the fluorescent indicator quin-2. The [Ca2+]i were around two times higher in 24-month-old rats than in adul...

journal_title：Neuroscience letters

authors： Martinez A,Vitórica J,Satrústegui J

更新日期：1988-06-07 00:00:00

abstract：:In this study we evaluated oxidative stress (lipid peroxidation and protein oxidation) and thiol redox state [TRS: glutathione (GSH), glutathione disulfide (GSSG), cysteine (CSH), protein (P) thiols (PSH) and protein and non-protein (NP) mixed/symmetric disulfides (PSSR, NPSSR, NPSSC, PSSP)] in hippocampus after penty...

journal_title：Neuroscience letters

authors： Patsoukis N,Zervoudakis G,Panagopoulos NT,Georgiou CD,Angelatou F,Matsokis NA

更新日期：2004-03-04 00:00:00

abstract：:Genome-wide analysis of miRNA expression has revealed increased levels of miR-144 in the brains of Alzheimer's disease (AD) patients. Nuclear factor erythroid 2-related factor 2 (NRF2), a potential target of miR-144, is a central regulator of antioxidant response, and plays an important role in glutathione (GSH) biosy...

journal_title：Neuroscience letters

authors： Zhou C,Zhao L,Zheng J,Wang K,Deng H,Liu P,Chen L,Mu H

更新日期：2017-08-10 00:00:00

abstract：:The aim of the present study is to investigate the effects of orphanin FQ (OFQ) microinjected into the nucleus raphe magnus (NRM) and the nucleus reticularis gigantocellularis (NGC) on pain modulation. The tail-flick latency (TFL) was used as a behavioral index of nociceptive responsiveness. The result showed microinj...

journal_title：Neuroscience letters

authors： Yang Z,Zhang Y,Wu G

更新日期：2001-06-22 00:00:00

abstract：:Application of strychnine sulfate (10-50 mu M) to the anterior hindlimb enlargement of the turtle spinal cord increased the amplitude of the ipsilateral fictive flexion reflex and revealed a contralateral (crossed) fictive flexion reflex response to cutaneous stimulation of the foot. Strychnine abolished the crossed i...

journal_title：Neuroscience letters

authors： Currie SN,Lee S

更新日期：1996-02-23 00:00:00

abstract：:Children and adolescents with Autism Spectrum Disorder (ASD) are characterized by an impaired Theory of Mind (ToM). Recent evidence suggested that two aspects of ToM (cognitive ToM versus affective ToM) are differentially impaired in individuals with ASD. In this study, we examined the neural correlates of cognitive a...

journal_title：Neuroscience letters

authors： Kim E,Kyeong S,Cheon KA,Park B,Oh MK,Chun JW,Park HJ,Kim JJ,Song DH

更新日期：2016-05-16 00:00:00

abstract：:Super-resolution microscopy techniques offer subdiffraction limited resolution that is two- to ten-fold improved compared to that offered by conventional confocal microscopy. This breakthrough in resolution for light microscopy has contributed to new findings in neuroscience and synapse biology. This review will focus...

journal_title：Neuroscience letters

authors： Badawi Y,Nishimune H

更新日期：2020-01-10 00:00:00

abstract：:It is well established that calcium-dependent neurotransmitter release and exocytosis can be regulated by altering the cholesterol content of the plasma membrane. We have compared the influence of cholesterol depletion of synaptosomal plasma membrane by 15 mM methyl-beta-cyclodextrin (MCD) treatment on calcium-depende...

journal_title：Neuroscience letters

authors： Waseem TV,Kolos VA,Lapatsina LP,Fedorovich SV

更新日期：2006-09-11 00:00:00

abstract：:Hypoxic encephalopathy is a common cause of neonatal seizures and long-term neurological cognitive deficits. In rats at postnatal days 10-12 (P10-P12), global hypoxia induced spontaneous seizures and chronic brain injury, mimicking clinical aspects of neonatal hypoxia. Synaptic Ras-GTPase activating protein (SynGAP) h...

journal_title：Neuroscience letters

authors： Yang SN,Huang CB,Yang CH,Lai MC,Chen WF,Wang CL,Wu CL,Huang LT

更新日期：2004-11-16 00:00:00

abstract：:To investigate the role of Cl(-)-stimulated Mg(2+)-ATPase (Cl(-)-ATPase) in neurons, we examined the effects of ethacrynic acid (0.3 mM), which completely inhibits Cl(-)-ATPase on the intracellular Cl- concentrations of cultured rat hippocampal neurons, using Cl(-)-sensitive fluorescent probes. Ethacrynic acid and ATP...

journal_title：Neuroscience letters

authors： Inoue M,Hara M,Zeng XT,Hirose T,Ohnishi S,Yasukura T,Uriu T,Omori K,Minato A,Inagaki C

更新日期：1991-12-16 00:00:00

abstract：:Plasma studies depict collisionless, collective movements of charged particles. In touch with these concepts, originally developed by the far-flung branch of high energy physics, here we evaluate the role of collective behaviors and long-range functional couplingsof charged particlesin brain dynamics. We build a novel...

journal_title：Neuroscience letters

authors： Tozzi A,Peters JF,Déli E

更新日期：2018-01-01 00:00:00

abstract：:The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings ...

journal_title：Neuroscience letters

authors： Sörös P,Knecht S,Bantel C,Imai T,Wüsten R,Pantev C,Lütkenhöner B,Bürkle H,Henningsen H

更新日期：2001-02-09 00:00:00

abstract：:In order to describe how high altitude affects the body during a one night stay at 4000m experiments were performed in a hypobaric chamber and compared to a study on Dachstein (mountain in Austria, 2700m). Ten subjects had to perform a reaction time task at different altitudes. The EEG and ECG were recorded simultaneo...

journal_title：Neuroscience letters

authors： Guger C,Krausert S,Domej W,Edlinger G,Tannheimer M

更新日期：2008-09-12 00:00:00

abstract：:Parkin gene mutations are by far the most common mutations in both familial Parkinson's disease (PD) and sporadic PD. Approximately, 50% of parkin mutations is exon dosage mutations (i.e., deletions and duplications of entire exons). Here, we first established a MLPA assay for quick detection of parkin exon rearrangem...

journal_title：Neuroscience letters

authors： Guo JF,Dong XL,Xu Q,Li N,Yan XX,Xia K,Tang BS

更新日期：2015-09-14 00:00:00

abstract：:C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of...

journal_title：Neuroscience letters

authors： Ma ZG,Wang J,Jiang H,Xie JX,Chen L

更新日期：2005-07-01 00:00:00

abstract：:Schisandra chinensis is commonly used for food and as a traditional remedy for the treatment of neuronal disorders. However, it is unclear which component of S. chinensis is responsible for its neuropharmacological effects. To answer this question, we isolated α-iso-cubebene, a dibenzocyclooctadiene lignin, from S. ch...

journal_title：Neuroscience letters

authors： Park SY,Park SJ,Park NJ,Joo WH,Lee SJ,Choi YW

更新日期：2013-10-25 00:00:00

abstract：:Rats subjected to forced oral self-administration of morphine solutions without or in combination with two daily i.p. injections of morphine preferred drinking water when this was offered in addition to morphine solutions. The daily intake of morphine during the terminal phase of self-administration of morphine was 50...

journal_title：Neuroscience letters

authors： Jurna I,Baldauf J,Zenz M

更新日期：1992-04-13 00:00:00

abstract：:Neuropathic pain (NP) is one of the most common complications after spinal cord injury (SCI), but no protein biomarkers has ever been introduced into clinical diagnosis. Previous studies implicated that toll-like receptor (TLR) 4 played a critical role in the development of NP in animal SCI models. Here, a total of 14...

journal_title：Neuroscience letters

authors： Xu J,E X,Liu H,Li F,Cao Y,Tian J,Yan J

更新日期：2015-05-19 00:00:00

abstract：:Abnormalities of cortical representational maps and their plasticity have been described in dystonia. A common polymorphism for BDNF has been associated with abnormal cortical plasticity, and thus might contribute to pathogenesis of dystonia in some subjects. As a first step towards this suggestion, the current study ...

journal_title：Neuroscience letters

authors： Cramer SC,Sampat A,Haske-Palomino M,Nguyen S,Procaccio V,Hermanowicz N

更新日期：2010-01-01 00:00:00

abstract：:White matter (WM) abnormality in somatization disorder (SD) has not been reported yet. This study was designed to elucidate the alterations in WM integrity in SD. A total of 25 patients with SD and 28 healthy controls were enrolled in the study. WM integrity was analyzed using tract-based spatial statistics. No differ...

journal_title：Neuroscience letters

authors： Zhang J,Jiang M,Yao D,Dai Y,Long L,Yu M,Liu J,Zhang Z,Xiao C,Guo W

更新日期：2015-07-10 00:00:00

abstract：:By using the monoclonal antibody Alz50, we studied the role of protein kinase C (PKC) in inducing A68 protein expression in a human neuronal cell line. Both phorbol 12-myristate 13-acetate and H7 strongly induced A68 protein, while HA1004 and calphoslin C had no effect. The results suggest that the inhibitor and activ...

journal_title：Neuroscience letters

authors： Zhang L

更新日期：1994-11-07 00:00:00